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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
The exact function of the MMACHC protein is not known, however, its C-terminal region shows similarity to TonB, a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Hence, it is postulated that this protein may have a role in the binding and intracellular trafficking of cobalamin. Mutations in this gene are associated with methylmalonic aciduria and homocystinuria type cblC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alkylcobalamin:glutathione S-alkyltransferase; CblC; Cyanocobalamin reductase (cyanide-eliminating); Cyanocobalamin reductase / alkylcobalamin dealkylase; Methylmalonic aciduria and homocystinuria type C protein; methylmalonic aciduria and homocystinuria type C protein homolog; MMACHC; RP11-291L19.3
Gene Aliases: 1810037K07Rik; cblC; MMACHC; RGD1310806
UniProt ID: (Human) Q9Y4U1, (Mouse) Q9CZD0
Entrez Gene ID: (Human) 25974, (Mouse) 67096, (Rat) 313520
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