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MMP-1 Antibody (BS-4597R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Rat stomach; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with MMP-1 Polyclonal Antibody, Unconjugated (bs-4597R) at 1:200 overnight at 4°C, DAB staining.
Product Details
BS-4597R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human MMP-1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Target Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Collagenase; collagenase-1; collagenase-like A; Fibroblast collagenase; Interstitial collagenase; Interstitial collagenase A; matrix metallo protease; matrix metallopeptidase 1 (interstitial collagenase); matrix metallopeptidase 1a; matrix metallopeptidase 1a (interstitial collagenase); matrix metalloprotease 1; matrix metalloproteinase 1; matrix metalloproteinase 1a (interstitial collagenase); Matrix metalloproteinase-1; Matrix metalloproteinase-1a; Matrix metalloproteinase1; Mcol-A; MMP; MMP-1; MMP-1a; MMPs
Gene Aliases: CLG; CLGN; Mcol-A; McolA; MMP-1; MMP1; Mmp1a
UniProt ID: (Rabbit) P13943, (Human) P03956, (Mouse) Q9EPL5
Entrez Gene ID: (Rabbit) 100009110, (Human) 4312, (Rat) 300339, (Mouse) 83995
proteolysis
viral process
extracellular matrix disassembly
collagen catabolic process
positive regulation of protein oligomerization
cellular protein metabolic process
leukocyte migration
luteinization
luteolysis
response to mechanical stimulus
positive regulation of fibroblast migration
response to inactivity
positive regulation of smooth muscle cell migration
cellular response to drug
response to drug
cellular response to lipopolysaccharide
cellular response to iron(III) ion
cellular response to vitamin D
cellular response to alkaloid
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to peptide hormone stimulus
cellular response to organic cyclic compound
cellular response to fluid shear stress
response to indole-3-methanol
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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