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Product Details
PA5-116704
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 104-272 of human MMP13 (NP_0024181)
Conjugate
Form
Liquid
Concentration
1.16 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2901335
Product Specific Information
Positive Samples: 293T, HeLa, MCF7, A-549
Immunogen sequence: YNVFPRTLKW SKMNLTYRIV NYTPDMTHSE VEKAFKKAFK VWSDVTPLNF TRLHDGIADI MISFGIKEHG DFYPFDGPSG LLAHAFPPGP NYGGDAHFDD DETWTSSSKG YNLFLVAAHE FGHSLGLDHS KDPGALMFPI YTYTGKSHFM LPDDDVQGIQ SLYGPGDED
Target Information
MMP13 (collagense 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN. MMP13 cleaves tripal helical collagens, including type I, II, and III collagen - but has the highest activity with soluble type II collagen. It can degrade collagen type IV, XIV, and X. MMP13 plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification. It is required for normal embryonic bone development and ossificaiton. Mutations affecting the gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Collagenase; Collagenase 3; collagenase-1; Collagenase-3; Collagenase3; interstitial collagenase; matrix metallo protease; matrix metalloproteinase 13; matrix metalloproteinase 13 (collagenase 3); Matrix metalloproteinase-13; MMP; MMP-13; MMPs; Procollagenase 3; UMRCASE
Gene Aliases: Clg; CLG3; MANDP1; MMP-13; Mmp1; MMP13
UniProt ID: (Human) P45452, (Mouse) P33435
Entrez Gene ID: (Human) 4322, (Mouse) 17386, (Rat) 171052
fibronectin binding
metalloendopeptidase activity
serine-type endopeptidase activity
calcium ion binding
collagen binding
zinc ion binding
calcium-dependent protein binding
low-density lipoprotein particle receptor binding
peptidase activity
metallopeptidase activity
hydrolase activity
metal ion binding
metalloprotease
luteolysis
osteoblast differentiation
response to hypoxia
endochondral ossification
growth plate cartilage development
proteolysis
heart development
parturition
response to mechanical stimulus
extracellular matrix disassembly
bone mineralization
collagen catabolic process
embryonic hindlimb morphogenesis
response to drug
peptide catabolic process
response to estrogen
cellular protein metabolic process
estrous cycle
bone morphogenesis
cellular response to fluid shear stress
positive regulation of pancreatic trypsinogen secretion
receptor internalization
cartilage development
ossification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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