Proteintech

MMP3 Monoclonal Antibody (1F5A9)

MMP3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MMP3 Antibody (66338-1-IG) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using (Product # 66338-1-IG) (MMP3 antibody) at dilution of 1:4,000 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

66338-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:10,000

View 25 publications 25 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1F5A9

Immunogen

MMP3 Fusion Protein Ag12359 (26-477 aa encoded by BC074869)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GEDTSMNLV QKYLENYYDL EKDVKQFVRR KDSGPVVKKI REMQKFLGLE VTGKLDSDTL EVMRKPRCGV PDVGHFRTFP GIPKWRKTHL TYRIVNYTPD LPKDAVDSAV EKALKVWEEV TPLTFSRLYE GEADIMISFA VREHGDFYPF DGPGNVLAHA YAPGPGINGD AHFDDDEQWT KDTTGTNLFL VAAHEIGHSL GLFHSANTEA LMYPLYHSLT DLTRFRLSQD DINGIQSLYG PPPDSPETPL VPTEPVPPEP GTPANCDPAL SFDAVSTLRG EILIFKDRHF WRKSLRKLEP ELHLISSFWP SLPSGVDAAY EVTSKDLVFI FKGNQFWAIR GNEVRAGYPR GIHTLGFPPT VRKIDAAISD KEKNKTYFFV EDKYWRFDEK RNSMEPGFPK QIAEDFPGID SKIDAVFEEF GFFYFFTGSS QLEFDPNAKK VTHTLKSNSW LNC (26-477 aa encoded by BC074869)

Target Information

MMP3 (stromelysin-1) belongs to the peptidase M10A subfamily. It is secreted in its pro-protein form, and is activated by extracellular proteinase cleavage. MMP3 is capable of binding to zinc and calcium ions, and has metallo-endopeptidase activity. The active enzyme degrades collagen, gelatin, fibronectin, and laminin. It is involved in normal cellular processes such as wound repair and tissue remodeling. Mutations in the gene can result in coronary heart disease 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Identification of gene signatures associated with ulcerative colitis and the association with immune infiltrates in colon cancer.

Frontiers in immunology

Pan Z,Lin H,Fu Y,Zeng F,Gu F,Niu G,Fang J,Gu B

Tue Feb 07 00:00:00 EST 2023

Identification of gene signatures associated with ulcerative colitis and the association with immune infiltrates in colon cancer.

Frontiers in immunology

Pan Z,Lin H,Fu Y,Zeng F,Gu F,Niu G,Fang J,Gu B

Tue Feb 07 00:00:00 EST 2023

Identification of gene signatures associated with ulcerative colitis and the association with immune infiltrates in colon cancer.

Frontiers in immunology

Pan Z,Lin H,Fu Y,Zeng F,Gu F,Niu G,Fang J,Gu B

Tue Feb 07 00:00:00 EST 2023

Identification of gene signatures associated with ulcerative colitis and the association with immune infiltrates in colon cancer.

Frontiers in immunology

Pan Z,Lin H,Fu Y,Zeng F,Gu F,Niu G,Fang J,Gu B

Tue Feb 07 00:00:00 EST 2023

Monotropein attenuates apoptosis and pyroptosis in chondrocytes and alleviates osteoarthritis progression in mice.

Chinese medicine

Li Z,Chen Z,Chen J,Liu Z,Li Z,Sun H,Wang X,Wei J,Cao X,Zheng D

Wed Apr 19 00:00:00 EDT 2023

METTL3 promotes SMSCs chondrogenic differentiation by targeting the MMP3, MMP13, and GATA3.

Regenerative therapy

Hu B,Zou X,Yu Y,Jiang Y,Xu H

Wed Mar 01 00:00:00 EST 2023

Sacha inchi albumin delays skin-aging by alleviating inflammation, oxidative stress and regulating gut microbiota in d-galactose induced-aging mice.

Journal of the science of food and agriculture

Zeng J,An M,Tian W,Wang K,Du B,Li P

Sat Jul 01 00:00:00 EDT 2023

Low-dose celecoxib-loaded PCL fibers reverse intervertebral disc degeneration by up-regulating CHSY3 expression.

Journal of nanobiotechnology

Wang Y,Zheng G,Xie X,Yu W,Wang J,Zang F,Yang C,Xiao Q,Zhang R,Wei L,Wu X,Liang L,Cao P,Xu C,Li J,Hu B,Zhang T,Wu J,Chen H

Fri Mar 03 00:00:00 EST 2023

Cellular-scale sex differences in extracellular matrix remodeling by valvular interstitial cells.

Heart and vessels

Simon LR,Scott AJ,Figueroa Rios L,Zembles J,Masters KS

Sun Jan 01 00:00:00 EST 2023

Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway.

International journal of molecular medicine

Sun W,Xie W,Huang D,Cui Y,Yue J,He Q,Jiang L,Xiong J,Sun W,Yi Q

Tue Nov 01 00:00:00 EDT 2022

Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway.

International journal of molecular medicine

Sun W,Xie W,Huang D,Cui Y,Yue J,He Q,Jiang L,Xiong J,Sun W,Yi Q

Tue Nov 01 00:00:00 EDT 2022

Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway.

International journal of molecular medicine

Sun W,Xie W,Huang D,Cui Y,Yue J,He Q,Jiang L,Xiong J,Sun W,Yi Q

Tue Nov 01 00:00:00 EDT 2022

Methylene blue prevents osteoarthritis progression and relieves pain in rats via upregulation of Nrf2/PRDX1.

Acta pharmacologica Sinica

Li JW,Wang RL,Xu J,Sun KY,Jiang HM,Sun ZY,Lv ZY,Xu XQ,Wu R,Guo H,Jiang Q,Shi DQ

Tue Feb 01 00:00:00 EST 2022

Methylene blue prevents osteoarthritis progression and relieves pain in rats via upregulation of Nrf2/PRDX1.

Acta pharmacologica Sinica

Li JW,Wang RL,Xu J,Sun KY,Jiang HM,Sun ZY,Lv ZY,Xu XQ,Wu R,Guo H,Jiang Q,Shi DQ

Tue Feb 01 00:00:00 EST 2022

Gaseous signal molecule SO₂ regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Zhao J,Wu Q,Yang T,Nie L,Liu S,Zhou J,Chen J,Jiang Z,Xiao T,Yang J,Chu C

Tue Nov 01 00:00:00 EDT 2022

Glycyrrhizin regulates rat TMJOA progression by inhibiting the HMGB1-RAGE/TLR4-NF-κB/AKT pathway.

Journal of cellular and molecular medicine

Hu Z,Xiao M,Cai H,Li W,Fang W,Long X

Tue Feb 01 00:00:00 EST 2022

ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Liu X,Zhao J,Jiang H,Guo H,Li Y,Li H,Feng Y,Ke J,Long X

Sat Oct 01 00:00:00 EDT 2022

Allergy-induced systemic inflammation impairs tendon quality.

EBioMedicine

Lehner C,Spitzer G,Langthaler P,Jakubecova D,Klein B,Weissenbacher N,Wagner A,Gehwolf R,Trinka E,Iglseder B,Paulweber B,Aigner L,Couillard-Després S,Weiss R,Tempfer H,Traweger A

Sat Jan 01 00:00:00 EST 2022

Role of ROR2 in promoting gastric cancer metastasis by enhancing c-JUN-mediated MMP3 transcription.

Annals of translational medicine

Ge X,Lin F,Wu Z,Lin Y,Tang W,McKay MJ,Sahu A,Lino-Silva LS,Tseng J,Li J

Sat Oct 01 00:00:00 EDT 2022

Single-cell RNA sequencing reveals the cell types heterogenicity of human discoid lateral meniscus cells.

Journal of cellular physiology

Sun H,Zhang W,Liu F,Li D,Cai Z,Huang Z,Chen M,Lin Z,Xu J,Ma R

Sun May 01 00:00:00 EDT 2022

Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis.

Frontiers in pharmacology

Pei W,Huang X,Ni B,Zhang R,Niu G,You H

Sat Oct 16 00:00:00 EDT 2021

Reducing Inflammation and Vascular Invasion in Intervertebral Disc Degeneration via Cystathionine-γ-Lyase Inhibitory Effect on E-Selectin.

Frontiers in cell and developmental biology

Xu H,Wei K,Tu J,Chen Y,He Y,Ding Y,Xu H,Bao X,Xie H,Fang H,Wang H

Tue Dec 07 00:00:00 EST 2021

Zonal-Layered Chondrocyte Sheets for Repairment of Full-Thickness Articular Cartilage Defect: A Mini-Pig Model.

Biomedicines

Shen PC,Lu CC,Chou SH,Liu ZM,Su SJ,Tien YC

Tue Nov 30 00:00:00 EST 2021

Effects of HDAC4 on IL-1β-induced matrix metalloproteinase expression regulated partially through the WNT3A/β-catenin pathway.

Chinese medical journal

Ning Q,Gan YH,Shi RR,Meng JH

Thu Apr 08 00:00:00 EDT 2021

Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes.

Chinese journal of natural medicines

Wang XH,Dai C,Wang J,Liu R,Li L,Yin ZS

Fri Oct 01 00:00:00 EDT 2021

Matrix metalloproteinase 3 regulates angiotensin II‑induced myocardial fibrosis cell viability, migration and apoptosis.

Molecular medicine reports

Shu J,Gu Y,Jin L,Wang H

Mon Feb 01 00:00:00 EST 2021

Scleraxis expressing scleral cells respond to inflammatory stimulation.

Histochemistry and cell biology

Atta G,Schroedl F,Kaser-Eichberger A,Spitzer G,Traweger A,Heindl LM,Tempfer H

Sun Aug 01 00:00:00 EDT 2021

Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect.

Frontiers in pharmacology

Lu R,Yu X,Liang S,Cheng P,Wang Z,He ZY,Lv ZT,Wan J,Mo H,Zhu WT,Chen AM

Tue Dec 21 00:00:00 EST 2021

ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.

Aging

Ding J,Zhang R,Li H,Ji Q,Cheng X,Thorne RF,Hondermarck H,Liu X,Shen C

Tue Apr 06 00:00:00 EDT 2021

High fibular osteotomy ameliorates medial compartment knee osteoarthritis in a rabbit model.

Journal of biomechanics

Yan F,Zhao X,Duan S,Maimaiti A,Qi Y,Li M,Maimaiti M,Li W

Tue Nov 09 00:00:00 EST 2021

Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.

BMC musculoskeletal disorders

Guo Z,Qiu C,Mecca C,Zhang Y,Bian J,Wang Y,Wu X,Wang T,Su W,Li X,Zhang W,Chen B,Xiang H

Wed Jan 13 00:00:00 EST 2021

17β-Estradiol alleviates intervertebral disc degeneration by inhibiting NF-κB signal pathway.

Life sciences

Wang H,Li Z,Huo Y,Tian T,Yang D,Ma L,Yang S,Ding W

Mon Nov 01 00:00:00 EDT 2021

Macromechanics and polycaprolactone fiber organization drive macrophage polarization and regulate inflammatory activation of tendon in vitro and in vivo.

Biomaterials

Schoenenberger AD,Tempfer H,Lehner C,Egloff J,Mauracher M,Bird A,Widmer J,Maniura-Weber K,Fucentese SF,Traweger A,Silvan U,Snedeker JG

Sat Aug 01 00:00:00 EDT 2020

TLR4 contributes to the damage of cartilage and subchondral bone in discectomy-induced TMJOA mice.

Journal of cellular and molecular medicine

Liu X,Cai HX,Cao PY,Feng Y,Jiang HH,Liu L,Ke J,Long X

Thu Oct 01 00:00:00 EDT 2020

Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.

Experimental biology and medicine (Maywood, N.J.)

Wei K,Dai J,Wang Z,Pei Y,Chen Y,Ding Y,Ding Q,Ahati P,Zhou X,Wang H,Fang H

Sun Mar 01 00:00:00 EST 2020

Oxymatrine Liposomes for Intervertebral Disc Treatment: Formulation, in vitro and vivo Assessments.

Drug design, development and therapy

Wang H,Ding Y,Zhang W,Wei K,Pei Y,Zou C,Zhang C,Ding J,Fang H,Tan S

Thu Feb 04 00:00:00 EST 2021

Long non-coding RNA lnc-DC in dendritic cells regulates trophoblast invasion via p-STAT3-mediated TIMP/MMP expression.

American journal of reproductive immunology (New York, N.Y. : 1989)

Zhang W,Yang M,Yu L,Hu Y,Deng Y,Liu Y,Xiao S,Ding Y

Mon Jun 01 00:00:00 EDT 2020

Bioinformatics

Protein Aliases: EC 3.4.24.17; EMS-2; matrix metallo protease; matrix metallopeptidase 3 (stromelysin 1, progelatinase); matrix metalloproteinase 3; matrix metalloproteinase 3 (stromelysin 1, progelatinase); Matrix metalloproteinase-3; MMP; MMP-3; MMPs; progelatinase; proteoglycanase; SL-1; stromelysin; stromelysin 1; Stromelysin-1; Stromelysin1; Transin-1; Transin1

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Gene Aliases: CHDS6; MMP-3; MMP10; MMP3; SL-1; SLN-1; SLN1; STMY; STMY1; STR-1; STR1

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UniProt ID: (Human) P08254, (Mouse) P28862

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Entrez Gene ID: (Pig) 396769, (Human) 4314, (Mouse) 17392, (Rat) 171045

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Function(s)

endopeptidase activity metalloendopeptidase activity serine-type endopeptidase activity calcium ion binding protein binding zinc ion binding peptidase activity metallopeptidase activity hydrolase activity protein complex binding metal ion binding metalloprotease

Process(es)

proteolysis negative regulation of hydrogen peroxide metabolic process extracellular matrix disassembly collagen catabolic process positive regulation of protein oligomerization cellular response to nitric oxide positive regulation of oxidative stress-induced cell death protein catabolic process regulation of cell migration positive regulation of cell migration negative regulation of protein kinase B signaling cellular response to amino acid stimulus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MMP3 Monoclonal Antibody (1F5A9)

MMP3 Antibody (66338-1-IG) in IHC (P)

Product Details

66338-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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