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MMP3 Antibody (MA5-51191) in IHC (P)
Immunohistochemistry analysis of MMP3 in paraffin-embedded human colon carcinoma. Samples were incubated with MMP3 Recombinant monoclonal antibody (Product # MA5-51191) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
MA5-51191
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
6K2S2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 385-477 of human MMP3 (NP_002413.1).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_3094268
Product Specific Information
Immunogen sequence: VRKIDAAISD KEKNKTYFFV EDKYWRFDEK RNSMEPGFPK QIAEDFPGID SKIDAVFEEF GFFYFFTGSS QLEFDPNAKK VTHTLKSNSW LNC
Target Information
MMP3 (stromelysin-1) belongs to the peptidase M10A subfamily. It is secreted in its pro-protein form, and is activated by extracellular proteinase cleavage. MMP3 is capable of binding to zinc and calcium ions, and has metallo-endopeptidase activity. The active enzyme degrades collagen, gelatin, fibronectin, and laminin. It is involved in normal cellular processes such as wound repair and tissue remodeling. Mutations in the gene can result in coronary heart disease 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.4.24.17; EMS-2; matrix metallo protease; matrix metalloproteinase 3; matrix metalloproteinase 3 (stromelysin 1, progelatinase); Matrix metalloproteinase-3; MMP; MMP-3; MMPs; progelatinase; proteoglycanase; SL-1; stromelysin 1; Stromelysin-1; Stromelysin1; Transin-1; Transin1
Gene Aliases: CHDS6; MMP-3; MMP3; SL-1; SLN-1; SLN1; STMY; STMY1; STR-1; STR1
UniProt ID: (Human) P08254, (Mouse) P28862
Entrez Gene ID: (Human) 4314, (Mouse) 17392, (Rat) 171045
proteolysis
negative regulation of hydrogen peroxide metabolic process
extracellular matrix disassembly
collagen catabolic process
positive regulation of protein oligomerization
cellular response to nitric oxide
positive regulation of oxidative stress-induced cell death
protein catabolic process
regulation of cell migration
positive regulation of cell migration
negative regulation of protein kinase B signaling
cellular response to amino acid stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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