Proteintech

MPO Monoclonal Antibody (4C11F6)

MPO Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 10

MPO Antibody (66177-1-IG) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Human liver tissue slide using (Product # 66177-1-Ig) MPO antibody at dilution of 1:800 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

MPO Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Product Image Gallery

Product Details

66177-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:800

Immunocytochemistry (ICC/IF)

View 14 publications 14 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgA

Class

Monoclonal

Type

Antibody

Clone

4C11F6

Immunogen

MPO Fusion Protein Ag17564 (606-657 aa encoded by BC130476)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.7 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: CGLPQPETV GQLGTVLRNL KLARKLMEQY GTPNNIDIWM GGVSEPLKRK GRV (606-657 aa encoded by BC130476)

Target Information

Myeloperoxidase (MPO) is a heme protein that is synthesized during myeloid differentiation and is a major component of neutrophil azurophilic granules. It is produced as a single chain precursor and subsequently cleaved into a light and heavy chain. The mature MPO is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme is responsible for producing hypohalous acids that are central to the microbicidal activity of neutrophils. Diseases that are associated with MPO include Myeloperoxidase Deficiency and Alzheimer's Disease, Familial, 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Neutrophil Extracellular Traps Release following Hypoxic-Ischemic Brain Injury in Newborn Rats Treated with Therapeutic Hypothermia.

International journal of molecular sciences

Bernis ME,Zweyer M,Maes E,Schleehuber Y,Sabir H

Fri Feb 10 00:00:00 EST 2023

Neutrophil Extracellular Traps Release following Hypoxic-Ischemic Brain Injury in Newborn Rats Treated with Therapeutic Hypothermia.

International journal of molecular sciences

Bernis ME,Zweyer M,Maes E,Schleehuber Y,Sabir H

Fri Feb 10 00:00:00 EST 2023

Hesperetin attenuates sepsis-induced intestinal barrier injury by regulating neutrophil extracellular trap formation via the ROS/autophagy signaling pathway.

Food & function

Chen F,Chu C,Wang X,Yang C,Deng Y,Duan Z,Wang K,Liu B,Ji W,Ding W

Thu May 11 00:00:00 EDT 2023

Hesperetin attenuates sepsis-induced intestinal barrier injury by regulating neutrophil extracellular trap formation via the ROS/autophagy signaling pathway.

Food & function

Chen F,Chu C,Wang X,Yang C,Deng Y,Duan Z,Wang K,Liu B,Ji W,Ding W

Thu May 11 00:00:00 EDT 2023

Hesperetin attenuates sepsis-induced intestinal barrier injury by regulating neutrophil extracellular trap formation via the ROS/autophagy signaling pathway.

Food & function

Chen F,Chu C,Wang X,Yang C,Deng Y,Duan Z,Wang K,Liu B,Ji W,Ding W

Thu May 11 00:00:00 EDT 2023

Hesperetin attenuates sepsis-induced intestinal barrier injury by regulating neutrophil extracellular trap formation via the ROS/autophagy signaling pathway.

Food & function

Chen F,Chu C,Wang X,Yang C,Deng Y,Duan Z,Wang K,Liu B,Ji W,Ding W

Thu May 11 00:00:00 EDT 2023

ETV4 Mediated Tumor-Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhang Q,Liu S,Wang H,Xiao K,Lu J,Chen S,Huang M,Xie R,Lin T,Chen X

Sat Apr 01 00:00:00 EDT 2023

Elevated neutrophil extracellular traps by HBV-mediated S100A9-TLR4/RAGE-ROS cascade facilitate the growth and metastasis of hepatocellular carcinoma.

Cancer communications (London, England)

Zhan X,Wu R,Kong XH,You Y,He K,Sun XY,Huang Y,Chen WX,Duan L

Wed Feb 01 00:00:00 EST 2023

IGFBP2 derived from PO-MSCs promote epithelial barrier destruction by activating FAK signaling in nasal polyps.

iScience

You B,Zhang T,Zhang W,Pei Y,Huang D,Lei Y,Zhang S,Qiu C,Zhang J,Gu Z,Cheng L,Chen J

Fri Mar 17 00:00:00 EDT 2023

Inhibition of neutrophil elastase prevents cigarette smoke exposure-induced formation of neutrophil extracellular traps and improves lung function in a mouse model of chronic obstructive pulmonary disease.

International immunopharmacology

Wang K,Liao Y,Li X,Wang R,Zeng Z,Cheng M,Gao L,Xu D,Wen F,Wang T,Chen J

Sun Jan 01 00:00:00 EST 2023

Targeted inhibition of FcRn reduces NET formation to ameliorate experimental ulcerative colitis by accelerating ANCA clearance.

International immunopharmacology

Wen C,Hu H,Yang W,Zhao Y,Zheng L,Jiang X,Wang L

Thu Dec 01 00:00:00 EST 2022

Increased co-expression of MEST and BRCA1 is associated with worse prognosis and immune infiltration in ovarian cancer.

Gynecologic oncology

Zhang J,Yu S,Li Q,Wang Q,Zhang J

Tue Mar 01 00:00:00 EST 2022

Leukocytes in Cerebral Thrombus Respond to Large-Vessel Occlusion in a Time-Dependent Manner and the Association of NETs With Collateral Flow.

Frontiers in immunology

Chen X,Wang L,Jiang M,Lin L,Ba Z,Tian H,Li G,Chen L,Liu Q,Hou X,Wu M,Liu L,Ju W,Zeng W,Zhou Z

Mon May 02 00:00:00 EDT 2022

Caspase-8 activation in neutrophils facilitates autoimmune kidney vasculitis through regulating CD4⁺ effector memory T cells.

Frontiers in immunology

Hu J,Huang Z,Yu M,Zhang P,Xia Z,Gao C

Fri Jan 06 00:00:00 EST 2023

Caspase-8 activation in neutrophils facilitates autoimmune kidney vasculitis through regulating CD4⁺ effector memory T cells.

Frontiers in immunology

Hu J,Huang Z,Yu M,Zhang P,Xia Z,Gao C

Fri Jan 06 00:00:00 EST 2023

Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/β-catenin pathway.

PloS one

Zhang ZY,Zhai C,Yang XY,Li HB,Wu LL,Li L

Fri Aug 26 00:00:00 EDT 2022

Si-Wu-Tang ameliorates bile duct ligation-induced liver fibrosis via modulating immune environment.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Ma Z,Xue X,Bai J,Cai Y,Jin X,Jia K,Ding M,Lyu X,Li X

Tue Nov 01 00:00:00 EDT 2022

An integrated bioinformatic investigation of mitochondrial energy metabolism genes in colon adenocarcinoma followed by preliminary validation of CPT2 in tumor immune infiltration.

Frontiers in immunology

Cao Z,Lin J,Fu G,Niu L,Yang Z,Cai W

Mon Oct 03 00:00:00 EDT 2022

Neutrophil extracellular traps impair intestinal barrier functions in sepsis by regulating TLR9-mediated endoplasmic reticulum stress pathway.

Cell death & disease

Sun S,Duan Z,Wang X,Chu C,Yang C,Chen F,Wang D,Wang C,Li Q,Ding W

Fri Jun 11 00:00:00 EDT 2021

Neutrophil extracellular traps impair intestinal barrier functions in sepsis by regulating TLR9-mediated endoplasmic reticulum stress pathway.

Cell death & disease

Sun S,Duan Z,Wang X,Chu C,Yang C,Chen F,Wang D,Wang C,Li Q,Ding W

Fri Jun 11 00:00:00 EDT 2021

The Role of Formyl Peptide Receptor 1 in Uterine Contraction During Parturition.

Frontiers in pharmacology

Chen C,Zhu S,Bai L,Sui M,Chen D

Tue Aug 17 00:00:00 EDT 2021

Effect of BLV Infection on the Immune Function of Polymorphonuclear Neutrophil in Dairy Cows.

Frontiers in veterinary science

Lv G,Wang H,Wang J,Lian S,Wu R

Tue Oct 12 00:00:00 EDT 2021

Effect of Copper, Zinc, and Selenium on the Formation of Bovine Neutrophil Extracellular Traps.

Biological trace element research

Zhou X,Wang H,Lian S,Wang J,Wu R

Wed Sep 01 00:00:00 EDT 2021

Stromal Neutrophil Extracellular Trap Density Is an Independent Prognostic Factor for Cervical Cancer Recurrence.

Frontiers in oncology

Yan B,Dai X,Ma Q,Wu X

Tue Nov 07 00:00:00 EST 2023

Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice.

PLoS pathogens

Chida J,Hara H,Uchiyama K,Takahashi E,Miyata H,Kosako H,Tomioka Y,Ito T,Horiuchi H,Matsuda H,Kido H,Sakaguchi S

Sat Aug 01 00:00:00 EDT 2020

Interleukin 22 attenuated angiotensin II induced acute lung injury through inhibiting the apoptosis of pulmonary microvascular endothelial cells.

Scientific reports

Wu Z,Hu Z,Cai X,Ren W,Dai F,Liu H,Chang J,Li B

Fri May 19 00:00:00 EDT 2017

Interleukin 22 attenuated angiotensin II induced acute lung injury through inhibiting the apoptosis of pulmonary microvascular endothelial cells.

Scientific reports

Wu Z,Hu Z,Cai X,Ren W,Dai F,Liu H,Chang J,Li B

Fri May 19 00:00:00 EDT 2017

Dephosphorylation of Y685-VE-Cadherin Involved in Pulmonary Microvascular Endothelial Barrier Injury Induced by Angiotensin II.

Mediators of inflammation

Wu Z,Wang Z,Dai F,Liu H,Ren W,Chang J,Li B

Fri Aug 04 00:00:00 EDT 2017

Dephosphorylation of Y685-VE-Cadherin Involved in Pulmonary Microvascular Endothelial Barrier Injury Induced by Angiotensin II.

Mediators of inflammation

Wu Z,Wang Z,Dai F,Liu H,Ren W,Chang J,Li B

Fri Aug 04 00:00:00 EDT 2017

VE-cadherin involved in the pulmonary microvascular endothelial cell barrier injury induced by angiotensin II through modulating the cellular apoptosis and skeletal rearrangement.

American journal of translational research

Wu Z,Liu H,Ren W,Dai F,Chang J,Li B

Wed Sep 30 00:00:00 EDT 2020

VE-cadherin involved in the pulmonary microvascular endothelial cell barrier injury induced by angiotensin II through modulating the cellular apoptosis and skeletal rearrangement.

American journal of translational research

Wu Z,Liu H,Ren W,Dai F,Chang J,Li B

Wed Sep 30 00:00:00 EDT 2020

Persisting and Increasing Neutrophil Infiltration Associates with Gastric Carcinogenesis and E-cadherin Downregulation.

Scientific reports

Fu H,Ma Y,Yang M,Zhang C,Huang H,Xia Y,Lu L,Jin W,Cui D

Thu Jul 14 00:00:00 EDT 2016

Persisting and Increasing Neutrophil Infiltration Associates with Gastric Carcinogenesis and E-cadherin Downregulation.

Scientific reports

Fu H,Ma Y,Yang M,Zhang C,Huang H,Xia Y,Lu L,Jin W,Cui D

Thu Jul 14 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: MPO; Myeloperoxidase

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Gene Aliases: MPO

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UniProt ID: (Human) P05164

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Entrez Gene ID: (Human) 4353, (Rat) 303413

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Function(s)

chromatin binding peroxidase activity heparin binding heme binding metal ion binding peroxidase

Process(es)

response to yeast hypochlorous acid biosynthetic process respiratory burst involved in defense response defense response response to oxidative stress aging response to mechanical stimulus removal of superoxide radicals response to food response to lipopolysaccharide low-density lipoprotein particle remodeling hydrogen peroxide catabolic process negative regulation of apoptotic process negative regulation of growth of symbiont in host defense response to fungus oxidation-reduction process response to gold nanoparticle defense response to Gram-positive bacterium

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MPO Monoclonal Antibody (4C11F6)

MPO Antibody (66177-1-IG) in IHC (P)

Product Details

66177-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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