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The antibody detects endogenous levels of total MRPL39 protein.
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 39S ribosomal protein L39, mitochondrial; 39S ribosomal protein L5, mitochondrial; L39mt; L5mt; Large ribosomal subunit protein mL39; MRP-L39; ribosomal protein, mitochondrial, L5
Gene Aliases: C21orf8; C21orf92; L39mt; MRP-L5; MRPL39; MRPL5; MSTP003; ORF22; PRED22; PRED66; RPML5
UniProt ID: (Human) Q9NYK5, (Mouse) Q9JKF7
Entrez Gene ID: (Human) 54148, (Mouse) 27393
Molecular Function:
aminoacyl-tRNA synthetase
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