Proteintech

MSH2 Polyclonal Antibody

MSH2 Antibody in Immunocytochemistry (ICC/IF)

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MSH2 Antibody (15520-1-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using MSH2 antibody 15520-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

MSH2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

MSH2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15520-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 10 publications 10 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 2 publications 2 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MSH2 Fusion Protein Ag7835 (585-934 aa encoded by BC021566)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SSGYVEPMQ TLNDVLAQLD AVVSFAHVSN GAPVPYVRPA ILEKGQGRII LKASRHACVE VQDEIAFIPN DVYFEKDKQM FHIITGPNMG GKSTYIRQTG VIVLMAQIGC FVPCESAEVS IVDCILARVG AGDSQLKGVS TFMAEMLETA SILRSATKDS LIIIDELGRG TSTYDGFGLA WAISEYIATK IGAFCMFATH FHELTALANQ IPTVNNLHVT ALTTEETLTM LYQVKKGVCD QSFGIHVAEL ANFPKHVIEC AKQKALELEE FQYIGESQGY DIMEPAAKKC YLEREQGEKI IQEFLSKVKQ MPFTEMSEEN ITIKLKQLKA EVIAKNNSFV NEIISRIKVT T (585-934 aa encoded by BC021566)

Target Information

Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

NAT10 mediated mRNA acetylation modification patterns associated with colon cancer progression and microsatellite status.

Epigenetics

Zhang H,Shan W,Yang Z,Zhang Y,Wang M,Gao L,Zeng L,Zhao Q,Liu J

Fri Dec 01 00:00:00 EST 2023

Targeting DNA polymerase β elicits synthetic lethality with mismatch repair deficiency in acute lymphoblastic leukemia.

Leukemia

Teng JY,Yang DP,Tang C,Fang HS,Sun HY,Xiang YN,Li XM,Yang F,Xia RX,Fan F,Liu J,Yu J,Hu JC,Li BS,Li H,Meng FL,Duan CW,Zhou BS

Thu Jun 01 00:00:00 EDT 2023

Loss of TDP-43 promotes somatic CAG repeat expansion in Huntington's disease knock-in mice.

Progress in neurobiology

Bai D,Zhu L,Jia Q,Duan X,Chen L,Wang X,Hou J,Jiang G,Yang S,Li S,Li XJ,Yin P

Tue Aug 01 00:00:00 EDT 2023

Molecular Classification in Patients With Endometrial Cancer After Fertility-Preserving Treatment: Application of ProMisE Classifier and Combination of Prognostic Evidence.

Frontiers in oncology

Ran X,Hu T,Li Z

Sat Jul 16 00:00:00 EDT 2022

In Situ Peroxidase Labeling Followed by Mass-Spectrometry Reveals TIA1 Interactome.

Biology

Gourdomichali O,Zonke K,Kattan FG,Makridakis M,Kontostathi G,Vlahou A,Doxakis E

Fri Feb 11 00:00:00 EST 2022

Lack of association of somatic CAG repeat expansion with striatal neurodegeneration in HD knock-in animal models.

Human molecular genetics

Bai D,Yin P,Zhang Y,Sun F,Chen L,Lin L,Yan S,Li S,Li XJ

Wed Jul 28 00:00:00 EDT 2021

Lack of association of somatic CAG repeat expansion with striatal neurodegeneration in HD knock-in animal models.

Human molecular genetics

Bai D,Yin P,Zhang Y,Sun F,Chen L,Lin L,Yan S,Li S,Li XJ

Wed Jul 28 00:00:00 EDT 2021

Chemotherapy and mismatch repair deficiency cooperate to fuel TP53 mutagenesis and ALL relapse.

Nature cancer

Yang F,Brady SW,Tang C,Sun H,Du L,Barz MJ,Ma X,Chen Y,Fang H,Li X,Kolekar P,Pathak O,Cai J,Ding L,Wang T,von Stackelberg A,Shen S,Eckert C,Klco JM,Chen H,Duan C,Liu Y,Li H,Li B,Kirschner-Schwabe R,Zhang J,Zhou BS

Sun Aug 01 00:00:00 EDT 2021

Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia by inhibiting MSH2.

Cell death & disease

Liu P,Ma D,Wang P,Pan C,Fang Q,Wang J

Tue Jan 05 00:00:00 EST 2021

Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia by inhibiting MSH2.

Cell death & disease

Liu P,Ma D,Wang P,Pan C,Fang Q,Wang J

Tue Jan 05 00:00:00 EST 2021

Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia by inhibiting MSH2.

Cell death & disease

Liu P,Ma D,Wang P,Pan C,Fang Q,Wang J

Tue Jan 05 00:00:00 EST 2021

m⁶ A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.

The EMBO journal

Wang L,Hui H,Agrawal K,Kang Y,Li N,Tang R,Yuan J,Rana TM

Thu Oct 15 00:00:00 EDT 2020

Clinicopathological and survival characteristic of mismatch repair status in ovarian clear cell carcinoma.

Journal of surgical oncology

Zhu J,Ke G,Bi R,Wu X

Tue Sep 01 00:00:00 EDT 2020

Quantitative Proteomics Analysis Reveals Nuclear Perturbation in Human Glioma U87 Cells treated with Temozolomide.

Cell biochemistry and function

Guo J,Yi GZ,Liu Z,Sun X,Yang R,Guo M,Li Y,Li K,Li K,Wang X,Song H,Qi S,Huang G,Liu Y

Sun Mar 01 00:00:00 EST 2020

KALRN mutations promote antitumor immunity and immunotherapy response in cancer.

Journal for immunotherapy of cancer

Li M,Ma Y,Zhong Y,Liu Q,Chen C,Qiang L,Wang X

Thu Oct 01 00:00:00 EDT 2020

Aberrantly expressed HORMAD1 disrupts nuclear localization of MCM8-MCM9 complex and compromises DNA mismatch repair in cancer cells.

Cell death & disease

Liu K,Wang Y,Zhu Q,Li P,Chen J,Tang Z,Shen Y,Cheng X,Lu LY,Liu Y

Thu Jul 09 00:00:00 EDT 2020

Mismatch repair status as a beneficial predictor of fluorouracil-based adjuvant chemotherapy for pancreatic cancer.

Surgery

Liang D,Shi S,Liang C,Meng Q,Zhang B,Ni Q,Xu J,Yu X

Tue May 01 00:00:00 EDT 2018

Mismatch repair status as a beneficial predictor of fluorouracil-based adjuvant chemotherapy for pancreatic cancer.

Surgery

Liang D,Shi S,Liang C,Meng Q,Zhang B,Ni Q,Xu J,Yu X

Tue May 01 00:00:00 EDT 2018

A highly malignant case of neuroblastoma with substantial increase of single-nucleotide variants and normal mismatch repair system: A case report.

Medicine

Yuan LQ,Wang JH,Zhu K,Yang M,Gu WZ,Lai C,Li HM,Shu Q,Chen X

Fri Dec 01 00:00:00 EST 2017

A highly malignant case of neuroblastoma with substantial increase of single-nucleotide variants and normal mismatch repair system: A case report.

Medicine

Yuan LQ,Wang JH,Zhu K,Yang M,Gu WZ,Lai C,Li HM,Shu Q,Chen X

Fri Dec 01 00:00:00 EST 2017

Significance of p53 expression in background endometrium in endometrial carcinoma.

Virchows Archiv : an international journal of pathology

Nguyen TT,Hachisuga T,Urabe R,Kurita T,Kagami S,Kawagoe T,Shimajiri S,Nabeshima K

Mon Jun 01 00:00:00 EDT 2015

Significance of p53 expression in background endometrium in endometrial carcinoma.

Virchows Archiv : an international journal of pathology

Nguyen TT,Hachisuga T,Urabe R,Kurita T,Kagami S,Kawagoe T,Shimajiri S,Nabeshima K

Mon Jun 01 00:00:00 EDT 2015

Aberrant cytokeratin expression as a possible prognostic predictor in poorly differentiated colorectal carcinoma.

Journal of gastroenterology and hepatology

Yamagishi H,Imai Y,Okamura T,Fukuda K,Ono Y,Ban S,Inoue T,Ueda Y

Sun Dec 01 00:00:00 EST 2013

Aberrant cytokeratin expression as a possible prognostic predictor in poorly differentiated colorectal carcinoma.

Journal of gastroenterology and hepatology

Yamagishi H,Imai Y,Okamura T,Fukuda K,Ono Y,Ban S,Inoue T,Ueda Y

Sun Dec 01 00:00:00 EST 2013

Differential mucin phenotypes and their significance in a variation of colorectal carcinoma.

World journal of gastroenterology

Imai Y,Yamagishi H,Fukuda K,Ono Y,Inoue T,Ueda Y

Sun Jul 07 00:00:00 EDT 2013

Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-β in colorectal cells.

Experimental & molecular medicine

He YQ,Sheng JQ,Ling XL,Fu L,Jin P,Yen L,Rao J

Mon Dec 31 00:00:00 EST 2012

Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-β in colorectal cells.

Experimental & molecular medicine

He YQ,Sheng JQ,Ling XL,Fu L,Jin P,Yen L,Rao J

Mon Dec 31 00:00:00 EST 2012

Ectopic expression of human MutS homologue 2 on renal carcinoma cells is induced by oxidative stress with interleukin-18 promotion via p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) signaling pathways.

The Journal of biological chemistry

Mo C,Dai Y,Kang N,Cui L,He W

Fri Jun 01 00:00:00 EDT 2012

The Journal of biological chemistry

Mo C,Dai Y,Kang N,Cui L,He W

Fri Jun 01 00:00:00 EDT 2012

Estrogen stimulates the expression of mismatch repair gene hMLH1 in colonic epithelial cells.

Cancer prevention research (Philadelphia, Pa.)

Jin P,Lu XJ,Sheng JQ,Fu L,Meng XM,Wang X,Shi TP,Li SR,Rao J

Sun Aug 01 00:00:00 EDT 2010

Estrogen stimulates the expression of mismatch repair gene hMLH1 in colonic epithelial cells.

Cancer prevention research (Philadelphia, Pa.)

Jin P,Lu XJ,Sheng JQ,Fu L,Meng XM,Wang X,Shi TP,Li SR,Rao J

Sun Aug 01 00:00:00 EDT 2010

Bioinformatics

Protein Aliases: DNA mismatch repair protein Msh2; hMSH2; Msh2p; mutS homolog 2, colon cancer, nonpolyposis type 1; MutS protein homolog 2

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Gene Aliases: COCA1; FCC1; HNPCC; HNPCC1; LCFS2; MSH2

View more View less

UniProt ID: (Human) P43246

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Entrez Gene ID: (Human) 4436

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Function(s)

magnesium ion binding four-way junction DNA binding Y-form DNA binding heteroduplex DNA loop binding double-strand/single-strand DNA junction binding DNA binding double-stranded DNA binding single-stranded DNA binding protein binding ATP binding protein C-terminus binding ATPase activity centromeric DNA binding enzyme binding protein kinase binding mismatched DNA binding guanine/thymine mispair binding dinucleotide insertion or deletion binding single guanine insertion binding single thymine insertion binding dinucleotide repeat insertion binding oxidized purine DNA binding MutLalpha complex binding protein homodimerization activity ADP binding DNA metabolism protein

Process(es)

meiotic mismatch repair in utero embryonic development oxidative phosphorylation DNA repair mismatch repair postreplication repair double-strand break repair meiotic gene conversion cell cycle arrest reciprocal meiotic recombination germ cell development determination of adult lifespan male gonad development response to X-ray response to UV-B somatic hypermutation of immunoglobulin genes somatic recombination of immunoglobulin gene segments B cell mediated immunity B cell differentiation intra-S DNA damage checkpoint intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of neuron apoptotic process maintenance of DNA repeat elements negative regulation of reciprocal meiotic recombination isotype switching negative regulation of DNA recombination positive regulation of helicase activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MSH2 Polyclonal Antibody

MSH2 Antibody (15520-1-AP) in ICC/IF

Product Details

15520-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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