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Product Details
60161-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2H5F5
Immunogen
MSH2 Fusion Protein Ag7835 (585-934 aa encoded by BC021566)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Caprylic acid precipitation
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SSGYVEPMQ TLNDVLAQLD AVVSFAHVSN GAPVPYVRPA ILEKGQGRII LKASRHACVE VQDEIAFIPN DVYFEKDKQM FHIITGPNMG GKSTYIRQTG VIVLMAQIGC FVPCESAEVS IVDCILARVG AGDSQLKGVS TFMAEMLETA SILRSATKDS LIIIDELGRG TSTYDGFGLA WAISEYIATK IGAFCMFATH FHELTALANQ IPTVNNLHVT ALTTEETLTM LYQVKKGVCD QSFGIHVAEL ANFPKHVIEC AKQKALELEE FQYIGESQGY DIMEPAAKKC YLEREQGEKI IQEFLSKVKQ MPFTEMSEEN ITIKLKQLKA EVIAKNNSFV NEIISRIKVT T (585-934 aa encoded by BC021566)
Target Information
Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DNA mismatch repair protein Msh2; hMSH2; Msh2p; mutS homolog 2, colon cancer, nonpolyposis type 1; MutS protein homolog 2
Gene Aliases: COCA1; FCC1; HNPCC; HNPCC1; LCFS2; MSH2
UniProt ID: (Human) P43246
Entrez Gene ID: (Human) 4436
magnesium ion binding
four-way junction DNA binding
Y-form DNA binding
heteroduplex DNA loop binding
double-strand/single-strand DNA junction binding
DNA binding
double-stranded DNA binding
single-stranded DNA binding
protein binding
ATP binding
protein C-terminus binding
ATPase activity
centromeric DNA binding
enzyme binding
protein kinase binding
mismatched DNA binding
guanine/thymine mispair binding
dinucleotide insertion or deletion binding
single guanine insertion binding
single thymine insertion binding
dinucleotide repeat insertion binding
oxidized purine DNA binding
MutLalpha complex binding
protein homodimerization activity
ADP binding
DNA metabolism protein
meiotic mismatch repair
in utero embryonic development
oxidative phosphorylation
DNA repair
mismatch repair
postreplication repair
double-strand break repair
meiotic gene conversion
cell cycle arrest
reciprocal meiotic recombination
germ cell development
determination of adult lifespan
male gonad development
response to X-ray
response to UV-B
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
B cell mediated immunity
B cell differentiation
intra-S DNA damage checkpoint
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of neuron apoptotic process
maintenance of DNA repeat elements
negative regulation of reciprocal meiotic recombination
isotype switching
negative regulation of DNA recombination
positive regulation of helicase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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