Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
18120-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MSH6 Fusion Protein Ag12645 (1-400 aa encoded by BC004246)
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSRQSTLYS FFPKSPALSD ANKASARASR EGGRAAAAPG ASPSPGGDAA WSEAGPGPRP LARSASPPKA KNLNGGLRRS VAPAAPTSCD FSPGDLVWAK MEGYPWWPCL VYNHPFDGTF IREKGKSVRV HVQFFDDSPT RGWVSKRLLK PYTGSKSKEA QKGGHFYSAK PEILRAMQRA DEALNKDKIK RLELAVCDEP SEPEEEEEME VGTTYVTDKS EEDNEIESEE EVQPKTQGSR RSSRQIKKRR VISDSESDIG GSDVEFKPDT KEEGSSDEIS SGVGDSESEG LNSPVKVARK RKRMVTGNGS LKRKSSRKET PSATKQATSI SSETKNTLRA FSAPQNSESQ AHVSGGGDDS SRPTVWYHET LEWLKEEKRR DEHRRRPDHP DFDASTLYVP E (1-400 aa encoded by BC004246)
Target Information
The DNA mismatch repair MSH2/MSH6 heterodimer is responsible for the detection of DNA damage, and may promote apoptosis in normal cells, thus protecting mammals from ultraviolet-induced malignant transformation and hence the prevention of skin cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; hMSH6; mutS (E. coli) homolog 6; MutS alpha 160kDa subunit; mutS homolog 6; MutS protein homolog 6; MutS-alpha 160 kDa subunit; MutS-alpha 160kDa subunit; p160; rCG61559-like; Sperm associated protein; sperm-associated protein
Gene Aliases: AU044881; AW550279; GTBP; GTMBP; HNPCC5; HSAP; MSH6; p160
UniProt ID: (Human) P52701, (Mouse) P54276
Entrez Gene ID: (Rat) 100360342, (Human) 2956, (Mouse) 17688
magnesium ion binding
four-way junction DNA binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
ATP binding
ATPase activity
mismatched DNA binding
guanine/thymine mispair binding
single guanine insertion binding
single thymine insertion binding
oxidized purine DNA binding
MutLalpha complex binding
methylated histone binding
protein homodimerization activity
ADP binding
protein binding
nucleotide binding
DNA-dependent ATPase activity
single base insertion or deletion binding
DNA metabolism protein
DNA repair
mismatch repair
determination of adult lifespan
intrinsic apoptotic signaling pathway in response to DNA damage
response to UV
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
maintenance of DNA repeat elements
isotype switching
negative regulation of DNA recombination
positive regulation of helicase activity
intrinsic apoptotic signaling pathway
meiotic mismatch repair
reciprocal meiotic recombination
viral process
positive regulation of isotype switching
cellular response to DNA damage stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support