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MSP (or MST1) contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds.
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Protein Aliases: Hepatocyte growth factor-like protein; hepatocyte growth factor-like protein homolog; macrophage stimulating 1 (hepatocyte growth factor-like); Macrophage stimulatory protein; Macrophage-stimulating protein; MSP
Gene Aliases: D3F15S2; DNF15S2; HGFL; MSP; MST1; NF15S2
UniProt ID: (Human) P26927
Entrez Gene ID: (Human) 4485
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