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MSTN Antibody (PA5-115278) in IHC (P)
Immunohistochemistry analysis of MSTN in human liver cancer and adjacent normal tissues. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115278) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Product Details
PA5-115278
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MSTN(Accession O14793), corresponding to amino acid residues T240-F290.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2899914
Product Specific Information
Antibody detects endogenous levels of total GDF8 / Myostatin.
Target Information
The protein encoded by this gene is a member of the bone morphogenetic protein family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: compact; GDF-8; growth differentiation factor 8; Growth/differentiation factor 8; H-Myo-Propeptide; H-Myostatin; Myostatin
Gene Aliases: Cmpt; GDF8; MSLHP; MSTN
UniProt ID: (Human) O14793, (Rat) O35312, (Mouse) O08689
Entrez Gene ID: (Human) 2660, (Rat) 29152, (Mouse) 17700
positive regulation of defense response to virus by host
transforming growth factor beta receptor signaling pathway
muscle organ development
response to heat
response to gravity
positive regulation of pathway-restricted SMAD protein phosphorylation
skeletal muscle atrophy
negative regulation of muscle hypertrophy
response to muscle activity
ovulation cycle process
response to testosterone
negative regulation of kinase activity
regulation of apoptotic process
skeletal muscle tissue regeneration
regulation of MAPK cascade
response to estrogen
response to ethanol
negative regulation of myoblast differentiation
positive regulation of transcription, DNA-templated
negative regulation of insulin receptor signaling pathway
muscle cell cellular homeostasis
cell development
negative regulation of skeletal muscle tissue growth
response to electrical stimulus
negative regulation of protein kinase B signaling
SMAD protein signal transduction
cellular response to dexamethasone stimulus
mitophagy in response to mitochondrial depolarization
xenophagy
negative regulation of skeletal muscle satellite cell proliferation
negative regulation of satellite cell differentiation
negative regulation of myoblast proliferation
response to glucocorticoid
growth
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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