Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Sequence of this protein is as follows: SLRLRPFHLA AVRNEAVVIS GRKLAQQIKQ EVRQEVEEWV ASGNKRPHLS VILVGENPAS HSYVLNKTRA AAVVGINSET IMKPASISEE ELLNLINKLN NDDNVDGLLV QLPLPEHIDE RRICNAVSPD KDVDGFHVIN VGRMCLDQYS MLPATPWGVW EIIKRTGIPT LGKNVVVAGR SKNVGMPIAM LLHTDGAHER PGGDATVTIS HRYTPKEQLK KHTILADIVI SAAGIPNLIT ADMIKEGAAV IDVGINRVHD PVTAKPKLVG DVDFEGVRQK AGYITPVPGG VGPMTVAMLM KNTIIAAKKV LRLEEREVLK SKELGVATN
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7.
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Protein Aliases: Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase
Gene Aliases: MTHFD2; NMDMC
UniProt ID: (Human) P13995
Entrez Gene ID: (Human) 10797
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