Product References
MUC1-C Dictates PBRM1-Mediated Chronic Induction of Interferon Signaling, DNA Damage Resistance, and Immunosuppression in Triple-Negative Breast Cancer.
Molecular cancer research : MCR
Yamashita N,Morimoto Y,Fushimi A,Ahmad R,Bhattacharya A,Daimon T,Haratake N,Inoue Y,Ishikawa S,Yamamoto M,Hata T,Akiyoshi S,Hu Q,Liu T,Withers H,Liu S,Shapiro GI,Yoshizumi T,Long MD,Kufe D
MA5-11202 was used in ChIP assay to demonstrate that MUC1-C activates polybromo-1, and thereby chromatin remodeling of IFN-stimulated genes that promote chronic inflammation, DNA damage resistance, and immune evasion.
Wed Mar 01 00:00:00 EST 2023
MUC1-C Dictates PBRM1-Mediated Chronic Induction of Interferon Signaling, DNA Damage Resistance, and Immunosuppression in Triple-Negative Breast Cancer.
Molecular cancer research : MCR
Yamashita N,Morimoto Y,Fushimi A,Ahmad R,Bhattacharya A,Daimon T,Haratake N,Inoue Y,Ishikawa S,Yamamoto M,Hata T,Akiyoshi S,Hu Q,Liu T,Withers H,Liu S,Shapiro GI,Yoshizumi T,Long MD,Kufe D
MA5-11202 was used in ChIP assay to demonstrate that MUC1-C activates polybromo-1, and thereby chromatin remodeling of IFN-stimulated genes that promote chronic inflammation, DNA damage resistance, and immune evasion.
Wed Mar 01 00:00:00 EST 2023
MUC1-C intersects chronic inflammation with epigenetic reprogramming by regulating the set1a compass complex in cancer progression.
Communications biology
Bhattacharya A,Fushimi A,Wang K,Yamashita N,Morimoto Y,Ishikawa S,Daimon T,Liu T,Liu S,Long MD,Kufe D
MA5-11202 was used in Immunoprecipitation to indicate that MUC1-C regulates the SET1A COMPASS complex and the induction of genes that integrate NF-κB-mediated chronic inflammation with cancer progression.
Wed Oct 11 00:00:00 EDT 2023
An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1.
British journal of cancer
Aftab F,Rodriguez-Fuguet A,Silva L,Kobayashi IS,Sun J,Politi K,Levantini E,Zhang W,Kobayashi SS,Zhang WC
MA5-11202 was used in Immunocytochemistry-immunofluorescence to investigate the inhibitory effects of AICAR on MUC1 activity in EGFR-mutant lung cancer cells.
Mon May 01 00:00:00 EDT 2023
Molecular genetic and clinical characteristic analysis of primary signet ring cell carcinoma of urinary bladder identified by a novel OR2L5 mutation.
Cancer medicine
Alradhi M,Wen S,Safi M,Al-Danakh A,Wang H,Shopit A,Sun M,Fan B,Li X
MA5-11202 was used in Immunohistochemistry to identify 63 copy number variations (CNVs) with gain counts and 181 CNVs with loss counts.
Wed Feb 01 00:00:00 EST 2023
Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression.
Digestive diseases and sciences
Wei D,Wang L,Liu Y,Hafley MA,Tan L,Lorenzi PL,Yang P,Zuo X,Bresalier RS
MA5-11202 was used in Western Blotting to demonstrate a previously unidentified vitamin D/VDR-MUC1 signaling axis involved in the regulation of gemcitabine resistance in pancreatic ductal adenocarcinoma (PDA) and suggests that combinational therapies that include targeted activation of vitamin D/VDR signaling may improve the outcomes of patients with PDA.
Sat Jul 01 00:00:00 EDT 2023
Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression.
Digestive diseases and sciences
Wei D,Wang L,Liu Y,Hafley MA,Tan L,Lorenzi PL,Yang P,Zuo X,Bresalier RS
MA5-11202 was used in Western Blotting to demonstrate a previously unidentified vitamin D/VDR-MUC1 signaling axis involved in the regulation of gemcitabine resistance in pancreatic ductal adenocarcinoma (PDA) and suggests that combinational therapies that include targeted activation of vitamin D/VDR signaling may improve the outcomes of patients with PDA.
Sat Jul 01 00:00:00 EDT 2023
MUC1-mediated Macrophage Activation Promotes Colitis-associated Colorectal Cancer via Activating the Interleukin-6/ Signal Transducer and Activator of Transcription 3 Axis.
Cellular and molecular gastroenterology and hepatology
Sheng YH,Davies JM,Wang R,Wong KY,Giri R,Yang Y,Begun J,Florin TH,Hasnain SZ,McGuckin MA
Published figure using MUC1 monoclonal antibody (Product # MA5-11202) in Immunohistochemistry
Mon Sep 26 00:00:00 EDT 2022
MUC1-mediated Macrophage Activation Promotes Colitis-associated Colorectal Cancer via Activating the Interleukin-6/ Signal Transducer and Activator of Transcription 3 Axis.
Cellular and molecular gastroenterology and hepatology
Sheng YH,Davies JM,Wang R,Wong KY,Giri R,Yang Y,Begun J,Florin TH,Hasnain SZ,McGuckin MA
Published figure using MUC1 monoclonal antibody (Product # MA5-11202) in Immunohistochemistry
Mon Sep 26 00:00:00 EDT 2022
Multi-apical polarity of alveolar stem cells and their dynamics during lung development and regeneration.
iScience
Konkimalla A,Konishi S,Kobayashi Y,Kadur Lakshminarasimha Murthy P,Macadlo L,Mukherjee A,Elmore Z,Kim SJ,Pendergast AM,Lee PJ,Asokan A,Knudsen L,Bravo-Cordero JJ,Tata A,Tata PR
Published figure using MUC1 monoclonal antibody (Product # MA5-11202) in Immunohistochemistry
Fri Oct 21 00:00:00 EDT 2022
Multi-apical polarity of alveolar stem cells and their dynamics during lung development and regeneration.
iScience
Konkimalla A,Konishi S,Kobayashi Y,Kadur Lakshminarasimha Murthy P,Macadlo L,Mukherjee A,Elmore Z,Kim SJ,Pendergast AM,Lee PJ,Asokan A,Knudsen L,Bravo-Cordero JJ,Tata A,Tata PR
Published figure using MUC1 monoclonal antibody (Product # MA5-11202) in Immunohistochemistry
Fri Oct 21 00:00:00 EDT 2022
The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization.
Cell death & disease
Li Q,Chu Y,Li S,Yu L,Deng H,Liao C,Liao X,Yang C,Qi M,Cheng J,Chen G,Huang L
Published figure using MUC1 monoclonal antibody (Product # MA5-11202) in Immunoprecipitation
Wed Oct 26 00:00:00 EDT 2022
The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization.
Cell death & disease
Li Q,Chu Y,Li S,Yu L,Deng H,Liao C,Liao X,Yang C,Qi M,Cheng J,Chen G,Huang L
Published figure using MUC1 monoclonal antibody (Product # MA5-11202) in Immunoprecipitation
Wed Oct 26 00:00:00 EDT 2022
The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization.
Cell death & disease
Li Q,Chu Y,Li S,Yu L,Deng H,Liao C,Liao X,Yang C,Qi M,Cheng J,Chen G,Huang L
Published figure using MUC1 monoclonal antibody (Product # MA5-11202) in Immunoprecipitation
Wed Oct 26 00:00:00 EDT 2022
The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization.
Cell death & disease
Li Q,Chu Y,Li S,Yu L,Deng H,Liao C,Liao X,Yang C,Qi M,Cheng J,Chen G,Huang L
Published figure using MUC1 monoclonal antibody (Product # MA5-11202) in Immunoprecipitation
Wed Oct 26 00:00:00 EDT 2022
Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium.
mBio
Iverson E,Griswold K,Song D,Gagliardi TB,Hamidzadeh K,Kesimer M,Sinha S,Perry M,Duncan GA,Scull MA
MA5-11202 was used in Western Blotting and Immunocytochemistry to indicate that a recombinant IAV hemagglutinin (H3) and H3N2 virus can bind endogenous HAE MUC1.
Tue Aug 30 00:00:00 EDT 2022
Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium.
mBio
Iverson E,Griswold K,Song D,Gagliardi TB,Hamidzadeh K,Kesimer M,Sinha S,Perry M,Duncan GA,Scull MA
MA5-11202 was used in Western Blotting and Immunocytochemistry to indicate that a recombinant IAV hemagglutinin (H3) and H3N2 virus can bind endogenous HAE MUC1.
Tue Aug 30 00:00:00 EDT 2022
Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium.
mBio
Iverson E,Griswold K,Song D,Gagliardi TB,Hamidzadeh K,Kesimer M,Sinha S,Perry M,Duncan GA,Scull MA
MA5-11202 was used in Western Blotting and Immunocytochemistry to indicate that a recombinant IAV hemagglutinin (H3) and H3N2 virus can bind endogenous HAE MUC1.
Tue Aug 30 00:00:00 EDT 2022
A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts.
Immunity
Zindl CL,Witte SJ,Laufer VA,Gao M,Yue Z,Janowski KM,Cai B,Frey BF,Silberger DJ,Harbour SN,Singer JR,Turner H,Lund FE,Vallance BA,Rosenberg AF,Schoeb TR,Chen JY,Hatton RD,Weaver CT
MA5-11202 was used in Immunohistochemistry to demonstrate spatiotemporal differences in the production and action of IL-22 by ILCs and T cells during infection and reveal an indispensable role for IL-22-producing T cells in the protection of the intestinal crypts.
Tue Mar 08 00:00:00 EST 2022
Single-cell chromatin profiling of the primitive gut tube reveals regulatory dynamics underlying lineage fate decisions.
Nature communications
Smith RJ,Zhang H,Hu SS,Yung T,Francis R,Lee L,Onaitis MW,Dirks PB,Zang C,Kim TH
MA5-11202 was used in Immunohistochemistry-immunofluorescence to define the chromatin and transcriptional mechanisms of organ identity and lineage plasticity in development and adult homeostasis.
Thu May 26 00:00:00 EDT 2022
Targeting MUC1-C Suppresses Chronic Activation of Cytosolic Nucleotide Receptors and STING in Triple-Negative Breast Cancer.
Cancers
Yamashita N,Fushimi A,Morimoto Y,Bhattacharya A,Hagiwara M,Yamamoto M,Hata T,Shapiro GI,Long MD,Liu S,Kufe D
MA5-11202 was used in Immunoprecipitation to report here that MUC1-C is necessary for intrinsic expression of the RIG-I, MDA5 and cGAS cytosolic nucleotide pattern recognition receptors (PRRs) and the cGAS-stimulator of IFN genes (STING) in triple-negative breast cancer (TNBC) cells.
Tue May 24 00:00:00 EDT 2022
Targeting MUC1-C Suppresses Chronic Activation of Cytosolic Nucleotide Receptors and STING in Triple-Negative Breast Cancer.
Cancers
Yamashita N,Fushimi A,Morimoto Y,Bhattacharya A,Hagiwara M,Yamamoto M,Hata T,Shapiro GI,Long MD,Liu S,Kufe D
MA5-11202 was used in Immunoprecipitation to report here that MUC1-C is necessary for intrinsic expression of the RIG-I, MDA5 and cGAS cytosolic nucleotide pattern recognition receptors (PRRs) and the cGAS-stimulator of IFN genes (STING) in triple-negative breast cancer (TNBC) cells.
Tue May 24 00:00:00 EDT 2022
Asynchrony of Apical Polarization, Luminogenesis, and Functional Differentiation in the Developing Thyroid Gland.
Frontiers in endocrinology
Johansson E,Liang S,Moccia C,Carlsson T,Andersson D,Fagman H,Nilsson M
MA5-11202 was used in Immunohistochemistry to elucidate whether cells committed to a thyroid fate might be triggered to differentiate asynchronously related to maturation and developmental stage.
Wed Feb 16 00:00:00 EST 2022
The sialidase NEU1 directly interacts with the juxtamembranous segment of the cytoplasmic domain of mucin-1 to inhibit downstream PI3K-Akt signaling.
The Journal of biological chemistry
Hyun SW,Imamura A,Ishida H,Piepenbrink KH,Goldblum SE,Lillehoj EP
MA5-11202 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to indicate that NEU1 associates with the juxtamembranous region of the MUC1-CD to inhibit PI3K-Akt signaling independent of NEU1 catalytic activity.
Mon Nov 01 00:00:00 EDT 2021
Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors.
Developmental cell
Seymour PA,Collin CA,Egeskov-Madsen AR,Jørgensen MC,Shimojo H,Imayoshi I,de Lichtenberg KH,Kopan R,Kageyama R,Serup P
MA5-11202 was used in Immunocytochemistry to uncover the oscillating Notch activity in the developing pancreas, modulated by Jag1, is required to coordinate MPC growth and fate.
Mon Mar 23 00:00:00 EDT 2020
Nrf2 activation protects against lithium-induced nephrogenic diabetes insipidus.
JCI insight
Jobbagy S,Vitturi DA,Salvatore SR,Pires MF,Rowart P,Emlet DR,Ross M,Hahn S,St Croix C,Wendell SG,Subramanya AR,Straub AC,Tan RJ,Schopfer FJ
MA5-11202 was used in Immunohistochemistry, Western Blot, and Immunocytochemistry to identify that graded genetic activation of Nrf2 protects against Li-induced NDI (Li-NDI) and volume wasting via an aquaporin 2-independent mechanism.
Thu Jan 16 00:00:00 EST 2020
Nrf2 activation protects against lithium-induced nephrogenic diabetes insipidus.
JCI insight
Jobbagy S,Vitturi DA,Salvatore SR,Pires MF,Rowart P,Emlet DR,Ross M,Hahn S,St Croix C,Wendell SG,Subramanya AR,Straub AC,Tan RJ,Schopfer FJ
MA5-11202 was used in Immunohistochemistry, Western Blot, and Immunocytochemistry to identify that graded genetic activation of Nrf2 protects against Li-induced NDI (Li-NDI) and volume wasting via an aquaporin 2-independent mechanism.
Thu Jan 16 00:00:00 EST 2020
Nrf2 activation protects against lithium-induced nephrogenic diabetes insipidus.
JCI insight
Jobbagy S,Vitturi DA,Salvatore SR,Pires MF,Rowart P,Emlet DR,Ross M,Hahn S,St Croix C,Wendell SG,Subramanya AR,Straub AC,Tan RJ,Schopfer FJ
MA5-11202 was used in Immunohistochemistry, Western Blot, and Immunocytochemistry to identify that graded genetic activation of Nrf2 protects against Li-induced NDI (Li-NDI) and volume wasting via an aquaporin 2-independent mechanism.
Thu Jan 16 00:00:00 EST 2020
Nrf2 activation protects against lithium-induced nephrogenic diabetes insipidus.
JCI insight
Jobbagy S,Vitturi DA,Salvatore SR,Pires MF,Rowart P,Emlet DR,Ross M,Hahn S,St Croix C,Wendell SG,Subramanya AR,Straub AC,Tan RJ,Schopfer FJ
MA5-11202 was used in Immunohistochemistry, Western Blot, and Immunocytochemistry to identify that graded genetic activation of Nrf2 protects against Li-induced NDI (Li-NDI) and volume wasting via an aquaporin 2-independent mechanism.
Thu Jan 16 00:00:00 EST 2020
Nrf2 activation protects against lithium-induced nephrogenic diabetes insipidus.
JCI insight
Jobbagy S,Vitturi DA,Salvatore SR,Pires MF,Rowart P,Emlet DR,Ross M,Hahn S,St Croix C,Wendell SG,Subramanya AR,Straub AC,Tan RJ,Schopfer FJ
MA5-11202 was used in Immunohistochemistry, Western Blot, and Immunocytochemistry to identify that graded genetic activation of Nrf2 protects against Li-induced NDI (Li-NDI) and volume wasting via an aquaporin 2-independent mechanism.
Thu Jan 16 00:00:00 EST 2020
Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity.
Cell reports
Flasse L,Yennek S,Cortijo C,Barandiaran IS,Kraus MR,Grapin-Botton A
MA5-11202 was used in Immunohistochemistry to show that apical restriction of planar cell polarity (PCP) components is necessary for the maintenance of epithelial integrity.
Tue May 26 00:00:00 EDT 2020
A Sox2-Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells.
Oncogene
Domenici G,Aurrekoetxea-Rodríguez I,Simões BM,Rábano M,Lee SY,Millán JS,Comaills V,Oliemuller E,López-Ruiz JA,Zabalza I,Howard BA,Kypta RM,Vivanco MD
MA5-11202 was used in Western Blotting to reveal that Sox2 increases and estrogen reduces the expression of the transcription factor Sox9 which highlights the relevance of the SOX family transcription factors as therapeutic targets in breast cancer.
Mon Apr 01 00:00:00 EDT 2019
MUC1 downregulation promotes TNF-α-induced necroptosis in human bronchial epithelial cells via regulation of the RIPK1/RIPK3 pathway.
Journal of cellular physiology
Zhang H,Ji J,Liu Q,Xu S
MA5-11202 was used in Western Blotting to investigate the effects of mucin 1 on TNF-α-induced necroptosis in human bronchial epithelial cells and the underlying molecular mechanism.
Sun Sep 01 00:00:00 EDT 2019
Essential Role of Protein Arginine Methyltransferase 1 in Pancreas Development by Regulating Protein Stability of Neurogenin 3.
Diabetes & metabolism journal
Lee K,Kim H,Lee J,Oh CM,Song H,Kim H,Koo SH,Lee J,Lim A,Kim H
MA5-11202 was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to determine the role of PRMT1 in pancreas development.
Tue Oct 01 00:00:00 EDT 2019
Regulatory effect of dexamethasone on tracheal calcium processing proteins and mucosal secretion.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
Lee B,Ahn C,Jeon BH,Jung EM,Yoo YM,Jeung EB
MA5-11202 was used in Immunohistochemistry-immunofluorescence to suggest that glucocorticoids simultaneously can regulate the expression of calcium processing genes and tracheal mucosecretion.
Fri Feb 01 00:00:00 EST 2019
Neuraminidase 1-mediated desialylation of the mucin 1 ectodomain releases a decoy receptor that protects against Pseudomonas aeruginosa lung infection.
The Journal of biological chemistry
Lillehoj EP,Guang W,Hyun SW,Liu A,Hegerle N,Simon R,Cross AS,Ishida H,Luzina IG,Atamas SP,Goldblum SE
MA5-11202 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate MUC1-ED desialylation in lung infection.
Fri Jan 11 00:00:00 EST 2019
Generation and phenotypic characterization of Pde1a mutant mice.
PloS one
Wang X,Yamada S,LaRiviere WB,Ye H,Bakeberg JL,Irazabal MV,Chebib FT,van Deursen J,Harris PC,Sussman CR,Behfar A,Ward CJ,Torres VE
Published figure using MUC1 monoclonal antibody (Product # MA5-11202) in Immunohistochemistry
Fri Sep 29 00:00:00 EDT 2017
Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer.
Molecular cancer
Ahmad R,Alam M,Hasegawa M,Uchida Y,Al-Obaid O,Kharbanda S,Kufe D
MA511202 was used in western blot to determine effects of the MUC1-C subunit inhibitor (GO-203) on human colorectal cancer cells
Thu Feb 02 00:00:00 EST 2017
Recurrent intracranial neurenteric cyst with malignant transformation: A case report and literature review.
Oncology letters
Yang Y,Fang J,Li DA,Wang L,Ji N,Zhang J
MA5-11202 was used in immunohistochemistry - paraffin section to study a case report and literature review of recurrent intracranial neurenteric cyst with malignant transformation
Sun May 01 00:00:00 EDT 2016
MUC1 stimulates EGFR expression and function in endometrial cancer.
Oncotarget
Engel BJ,Bowser JL,Broaddus RR,Carson DD
MA511202 was used in ChIP assay, immunohistochemistry, and western blot to determine that MUC1 stimulates epidermal growth factor receptor expression and function in endometrial cancer
Tue May 31 00:00:00 EDT 2016
Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of Hhex in Mice.
Cellular and molecular gastroenterology and hepatology
Ferreira MJ,McKenna LB,Zhang J,Reichert M,Bakir B,Buza EL,Furth EE,Bogue CW,Rustgi AK,Kaestner KH
MA5-11202 was used in immunohistochemistry - paraffin section to study the contribution of hematopoietically expressed homeobox protein in ductal secretion and pancreatitis
Tue Sep 01 00:00:00 EDT 2015
Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts.
Developmental biology
Poncy A,Antoniou A,Cordi S,Pierreux CE,Jacquemin P,Lemaigre FP
MA5-11202 was used in immunohistochemistry - paraffin section to investigate the role of transcription factors SOX4 and SOX9 during the development of bile ducts
Sat Aug 15 00:00:00 EDT 2015
Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells.
Biochimica et biophysica acta
Tréhoux S,Lahdaoui F,Delpu Y,Renaud F,Leteurtre E,Torrisani J,Jonckheere N,Van Seuningen I
MA5-11202 was used in immunohistochemistry - paraffin section to determine if miRNA that target Muc1 are protective against pancreatic cancer
Thu Oct 01 00:00:00 EDT 2015
Mucin1 shifts Smad3 signaling from the tumor-suppressive pSmad3C/p21(WAF1) pathway to the oncogenic pSmad3L/c-Myc pathway by activating JNK in human hepatocellular carcinoma cells.
Oncotarget
Li Q,Liu G,Yuan H,Wang J,Guo Y,Chen T,Zhai R,Shao D,Ni W,Tai G
MA5-11202 was used in immunocytochemistry and western blot to study the shift of Smad3 signaling from the tumor-suppressive pSmad3C/p21(WAF1) pathway to the oncogenic pSmad3L/c-Myc pathway occurs by Mucin1 activating JNK in human hepatocellular carcinoma
Sat Feb 28 00:00:00 EST 2015
Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
Nature biotechnology
Huang SX,Islam MN,O'Neill J,Hu Z,Yang YG,Chen YW,Mumau M,Green MD,Vunjak-Novakovic G,Bhattacharya J,Snoeck HW
MA5-11202 was used in immunocytochemistry to develop a protocol for the efficient generation of airway and lung epithelial cells from human pluripotent stem cells
Wed Jan 01 00:00:00 EST 2014
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma.
Nature cell biology
von Figura G,Fukuda A,Roy N,Liku ME,Morris Iv JP,Kim GE,Russ HA,Firpo MA,Mulvihill SJ,Dawson DW,Ferrer J,Mueller WF,Busch A,Hertel KJ,Hebrok M
MA5-11202 was used in immunohistochemistry to study the formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma and the suppressive role of the Brg1 component of chromatin remodeling complexes
Sat Mar 01 00:00:00 EST 2014
MUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells.
Blood
Liu S,Yin L,Stroopinsky D,Rajabi H,Puissant A,Stegmaier K,Avigan D,Kharbanda S,Kufe D,Stone R
MA5-11202 was used in immunoprecipitation to study the activation of the FLT3 receptor by the MUC1-C oncoprotein in acute myeloid leukemia and the underlying mechanism
Thu Jan 30 00:00:00 EST 2014
MUC1 in macrophage: contributions to cigarette smoke-induced lung cancer.
Cancer research
Xu X,Padilla MT,Li B,Wells A,Kato K,Tellez C,Belinsky SA,Kim KC,Lin Y
MA5-11202 was used in western blot to study cigarette smoke-induced lung cancer and the role played by MUC1 expression in macrophages
Wed Jan 15 00:00:00 EST 2014
MUC1-C oncoprotein activates the ZEB1/miR-200c regulatory loop and epithelial-mesenchymal transition.
Oncogene
Rajabi H,Alam M,Takahashi H,Kharbanda A,Guha M,Ahmad R,Kufe D
MA5-11202 was used in ChIP assay to study the role of oncogenic MUC1-c in modulating EB1 and miR-200c expression and in promoting epithelial-mesenchymal transition
Thu Mar 27 00:00:00 EDT 2014
MUC1-C nuclear localization drives invasiveness of renal cancer cells through a sheddase/gamma secretase dependent pathway.
Oncotarget
Bouillez A,Gnemmi V,Gaudelot K,Hémon B,Ringot B,Pottier N,Glowacki F,Butruille C,Cauffiez C,Hamdane M,Sergeant N,Van Seuningen I,Leroy X,Aubert S,Perrais M
MA5-11202 was used in immunohistochemistry and western blot to study the role of ADAM10, ADAM17 and gamma-secretase in the mechanism by which nuclear MUC1-C drives renal cancer cell invasion
Sat Feb 15 00:00:00 EST 2014
Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1.
Hepatology (Baltimore, Md.)
Jeliazkova P,Jörs S,Lee M,Zimber-Strobl U,Ferrer J,Schmid RM,Siveke JT,Geisler F
MA5-11202 was used in immunohistochemistry to study the determination of the biliary fate of embryonic hepatoblasts and mature hepatocytes and the role played by Notch2
Sat Jun 01 00:00:00 EDT 2013
Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein.
Oncogene
Jin C,Rajabi H,Rodrigo CM,Porco JA,Kufe D
MA5-11202 was used in immunocytochemistry and western blot to study the inhibition of MUC1-C oncogene expression by blockade of eIF4A RNA helicase activity and the significance for breast cancer therapy
Thu Apr 25 00:00:00 EDT 2013
MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors.
Oncogene
Kitamoto S,Yokoyama S,Higashi M,Yamada N,Takao S,Yonezawa S
MA5-11202 was used in ChIP assay and western blot to study the mechanisms by which MUC1 promotes angiogenesis in response to hypoxia
Thu Sep 26 00:00:00 EDT 2013
Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features.
Cancer science
Matsubara D,Kishaba Y,Ishikawa S,Sakatani T,Oguni S,Tamura T,Hoshino H,Sugiyama Y,Endo S,Murakami Y,Aburatani H,Fukayama M,Niki T
MA5-11202 was used in western blot to investigate epithelial-to-mesenchymal transition and the progression of lung adenocarcinomas in patients displaying loss of BRG1 and BRM
Fri Feb 01 00:00:00 EST 2013
Oncogenic MUC1-C promotes tamoxifen resistance in human breast cancer.
Molecular cancer research : MCR
Kharbanda A,Rajabi H,Jin C,Raina D,Kufe D
MA5-11202 was used in ChIP assay to study the mechanism by which the oncogenic MUC1-C subunit promotes human breast cancer tamoxifen resistance
Mon Jul 01 00:00:00 EDT 2013
Disrupting BCR-ABL in combination with secondary leukemia-specific pathways in CML cells leads to enhanced apoptosis and decreased proliferation.
Molecular pharmaceutics
Woessner DW,Lim CS
MA5-11202 was used in western blot to examine the anti-tumor potential of BCR-ABL disruption and secondary leukemia-specific pathway inhibitors
Mon Jan 07 00:00:00 EST 2013
Expression of human full-length MUC1 inhibits the proliferation and migration of a B16 mouse melanoma cell line.
Oncology reports
Wang F,Li Q,Ni W,Fang F,Sun X,Xie F,Wang J,Wang F,Gao S,Tai G
MA5-11202 was used in immunoprecipitation to study the mechanisms by which expression of full length human MUC1 by the murine B16 melanoma cell inhibits its proliferation and invasiveness
Mon Jul 01 00:00:00 EDT 2013
Expression of underglycosylated MUC1 antigen in cancerous and adjacent normal breast tissues.
Clinical breast cancer
Ghosh SK,Pantazopoulos P,Medarova Z,Moore A
MA5-11202 was used in immunohistochemistry to study the potential diagnostic value of underglycosylated MUC1 antigen in breast cancer
Mon Apr 01 00:00:00 EDT 2013
Elimination of von Hippel-Lindau function perturbs pancreas endocrine homeostasis in mice.
PloS one
Puri S,García-Núñez A,Hebrok M,Cano DA
MA5-11202 was used in immunohistochemistry to study the effects of endocrine pancreatic deletion of von Hippel-Lindau factor on insulin and glucagon responses and glycemic homeostasis
Thu Jan 22 00:00:00 EST 2015
Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia.
Gut
Prévot PP,Simion A,Grimont A,Colletti M,Khalaileh A,Van den Steen G,Sempoux C,Xu X,Roelants V,Hald J,Bertrand L,Heimberg H,Konieczny SF,Dor Y,Lemaigre FP,Jacquemin P
MA5-11202 was used in immunocytochemistry to study pancreatic acinar-to-ductal metaplasia and the role played by the HNF6 and Sox9 transcription factors
Sat Dec 01 00:00:00 EST 2012
GATA4 and GATA6 control mouse pancreas organogenesis.
The Journal of clinical investigation
Carrasco M,Delgado I,Soria B,Martín F,Rojas A
MA5-11202 was used in immunohistochemistry - paraffin section to study the roles of GATA4 and GATA6 in mouse pancreas organogenesis
Mon Oct 01 00:00:00 EDT 2012
A novel anti-MUC1 antibody against the MUC1 cytoplasmic tail domain: use in sensitive identification of poorly differentiated cells in adenocarcinoma of the stomach.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Yonezawa S,Kitajima S,Higashi M,Osako M,Horinouchi M,Yokoyama S,Kitamoto S,Yamada N,Tamura Y,Shimizu T,Tabata M,Goto M
MA5-11202 was used in immunohistochemistry to study the value of a novel monoclonal antibody recognizing the cytoplasmic tail of MUC1 for identifying isolated cancer cells in patients with adenocarcinoma of the stomach
Mon Oct 01 00:00:00 EDT 2012
MUC1-C oncoprotein induces TCF7L2 transcription factor activation and promotes cyclin D1 expression in human breast cancer cells.
The Journal of biological chemistry
Rajabi H,Ahmad R,Jin C,Kosugi M,Alam M,Joshi MD,Kufe D
MA5-11202 was used in ChIP assay and western blot to study the role of TCF7L2 activation in the mechanism by which oncogenic MUC1-C promotes human breast cancer cell cyclin D1 expression
Fri Mar 23 00:00:00 EDT 2012
The MUC1 extracellular domain subunit is found in nuclear speckles and associates with spliceosomes.
PloS one
Kumar P,Lindberg L,Thirkill TL,Ji JW,Martsching L,Douglas GC
MA5-11202 was used in immunocytochemistry, immunohistochemistry, and western blot to determine if MUC1-N is expressed inside the nucleus
Mon Feb 11 00:00:00 EST 2013
Cooperative interaction between the MUC1-C oncoprotein and the Rab31 GTPase in estrogen receptor-positive breast cancer cells.
PloS one
Jin C,Rajabi H,Pitroda S,Li A,Kharbanda A,Weichselbaum R,Kufe D
MA5-11202 was used in ChIP assay and western blot to study the interaction between MUC1-C and Rab 31 GTPase and its role in driving overexpression of MUC1-C in breast cancer cells
Tue Mar 19 00:00:00 EDT 2013
MUC1-C oncoprotein suppresses reactive oxygen species-induced terminal differentiation of acute myelogenous leukemia cells.
Blood
Yin L,Wu Z,Avigan D,Rosenblatt J,Stone R,Kharbanda S,Kufe D
MA5-11202 was used in western blot to study the role of MUC1-C oncoprotein in terminal differentiation of acute myelogenous leukemia cells
Thu May 05 00:00:00 EDT 2011
Nm23-h1 indirectly promotes the survival of acute myeloid leukemia blast cells by binding to more mature components of the leukemic clone.
Cancer research
Lilly AJ,Khanim FL,Hayden RE,Luong QT,Drayson MT,Bunce CM
MA5-11202 was used in western blot to study the involvement of Nm23-h1 in the tumorigeneis of acute myeloid leukemia
Tue Feb 01 00:00:00 EST 2011
A mouse model for monitoring islet cell genesis and developing therapies for diabetes.
Disease models & mechanisms
Shimajiri Y,Kosaka Y,Scheel DW,Lynn FC,Kishimoto N,Wang J,Zhao S,German MS
MA5-11202 was used in immunohistochemistry to develop a mouse model for monitoring islet cell genesis and developing therapies for diabetes
Tue Mar 01 00:00:00 EST 2011
Intrinsic mitochondrial membrane potential and associated tumor phenotype are independent of MUC1 over-expression.
PloS one
Houston MA,Augenlicht LH,Heerdt BG
MA5-11202 was used in western blot to study whether intrinsic mitochondrial membrane potential and associated tumorigenic phenotypes are linked to MUC1 expression
Fri Feb 10 00:00:00 EST 2012
MUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cells.
PloS one
Kosugi M,Ahmad R,Alam M,Uchida Y,Kufe D
MA5-11202 was used in immunoprecipitation to study the role of MUC1-C oncoprotein in regulating glycolysis and pyruvate kinase M2 activity in cancer cells
Mon Apr 09 00:00:00 EDT 2012
Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer.
Oncogene
Khodarev N,Ahmad R,Rajabi H,Pitroda S,Kufe T,McClary C,Joshi MD,MacDermed D,Weichselbaum R,Kufe D
MA5-11202 was used in immunoprecipitation and western blot to study the coexpression of the MUC1 oncoprotein and STAT1 pathways and poor prognosis in human breast cancer
Thu Feb 11 00:00:00 EST 2010
Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas.
BMC developmental biology
Kopinke D,Murtaugh LC
MA5-11202 was used in immunohistochemistry - frozen section to investigate the origins of new beta-cells
Thu Apr 08 00:00:00 EDT 2010
MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression.
Cancer research
Aubert S,Fauquette V,Hémon B,Lepoivre R,Briez N,Bernard D,Van Seuningen I,Leroy X,Perrais M
MA5-11202 was used in immunohistochemistry to examine the therapeutic significance of MUC1 in clear renal cell carcinoma
Wed Jul 15 00:00:00 EDT 2009
Hypoxia enhances MUC1 expression in a lung adenocarcinoma cell line.
Biochemical and biophysical research communications
Mikami Y,Hisatsune A,Tashiro T,Isohama Y,Katsuki H
MA5-11202 was used in western blot to study the mechanism by which hypoxia induces MUC1 expression in a lung adenocarcinoma cell line
Fri Feb 20 00:00:00 EST 2009
A minimal fragment of MUC1 mediates growth of cancer cells.
PloS one
Mahanta S,Fessler SP,Park J,Bamdad C
MA5-11202 was used in western blot to examine the cleavage of mucin and its role in tumorigenesis
Wed Apr 30 00:00:00 EDT 2008
Diagnostic value of mucins (MUC1, MUC2 and MUC5AC) expression profile in endoscopic ultrasound-guided fine-needle aspiration specimens of the pancreas.
International journal of cancer
Wang Y,Gao J,Li Z,Jin Z,Gong Y,Man X
MA5-11202 was used in immunohistochemistry to investigate the expression profiles of mucins in endoscopic ultrasound-guided fine-needle aspiration specimens of the pancreas
Sat Dec 15 00:00:00 EST 2007
Localization of putative stem cells and four cell populations with different differentiation degree in mouse mammary anlagen.
Histochemistry and cell biology
Han J,Cao S,Jin H,Liu Y,Wang M,Song J,Li N
MA5-11202 was used in immunocytochemistry to study the precise localization of putative stem cells and other cells within the embryonic mammary gland
Sat Jul 01 00:00:00 EDT 2006
Multiple tumor types may originate from bone marrow-derived cells.
Neoplasia (New York, N.Y.)
Liu C,Chen Z,Chen Z,Zhang T,Lu Y
MA5-11202 was used in immunohistochemistry to examine the role of bone marrow-derived cells in human tumorigenesis
Fri Sep 01 00:00:00 EDT 2006
Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Vasir B,Avigan D,Wu Z,Crawford K,Turnquist S,Ren J,Kufe D
MA5-11202 was used in western blot to study the role of IL-7 in the induction of MUC1 expression and T cell polarization by dendritic cells
Tue Feb 15 00:00:00 EST 2005
MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress.
The Journal of biological chemistry
Yin L,Huang L,Kufe D
MA5-11202 was used in western blot to study the role of the MUC1 oncoprotein in activating FOXO3a in a survival response to oxidative stress
Fri Oct 29 00:00:00 EDT 2004
