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MUM1/IRF4 Polyclonal Antibody

MUM1/IRF4 Antibody in Flow Cytometry (Flow)

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MUM1/IRF4 Antibody (11247-2-AP) in Flow

1X10^6 Raji cells were stained with 0.2ug MUM1/IRF4 antibody (11247-2-AP, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L) with dilution 1:1500.

MUM1/IRF4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

MUM1/IRF4 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11247-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MUM1/IRF4 Fusion Protein Ag1762 (1-451 aa encoded by BC015752)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.44 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MNLEGGGRG GEFGMSAVSC GNGKLRQWLI DQIDSGKYPG LVWENEEKSI FRIPWKHAGK QDYNREEDAA LFKAWALFKG KFREGIDKPD PPTWKTRLRC ALNKSNDFEE LVERSQLDIS DPYKVYRIVP EGAKKGAKQL TLEDPQMSMS HPYTMTTPYP SLPAQQVHNY MMPPLDRSWR DYVPDQPHPE IPYQCPMTFG PRGHHWQGPA CENGCQVTGT FYACAPPESQ APGVPTEPSI RSAEALAFSD CRLHICLYYR EILVKELTTS SPEGCRISHG HTYDASNLDQ VLFPYPEDNG QRKNIEKLLS HLERGVVLWM APDGLYAKRL CQSRIYWDGP LALCNDRPNK LERDQTCKLF DTQQFLSELQ AFAHHGRSLP RFQVTLCFGE EFPDPQRQRK LITAHVEPLL ARQLYYFAQQ NSGHFLRGYD LPEHISNPED YHRSIRHSSI QE (1-451 aa encoded by BC015752)

Target Information

The IRF (interferon regulatory factor) family of transcription factors are characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. IRF4 is lymphocyte specific and negatively regulates toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function.

British journal of pharmacology

Liao W,Foo HYC,Tran TNQ,Chai CLL,Wong WSF

Sat Apr 01 00:00:00 EDT 2023

Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism.

Cellular signalling

Tian J,Zhang L,La X,Fan X,Li A,Wu C,An Y,Yan S,Dong X,Wu H,Li Z

Tue Aug 01 00:00:00 EDT 2023

Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome.

Diabetes

Yao T,Yan H,Zhu X,Zhang Q,Kong X,Guo S,Feng Y,Wang H,Hua Y,Zhang J,Mittelman SD,Tontonoz P,Zhou Z,Liu T,Kong X

Tue Nov 01 00:00:00 EDT 2022

Cayratia japonica Prevents Ulcerative Colitis by Promoting M2 Macrophage Polarization through Blocking the TLR4/MAPK/NF-κB Pathway.

Mediators of inflammation

Sun J,Zhao P,Ding X,Li F,Jiang J,Huang H,Ji L

Wed Jan 11 00:00:00 EST 2023

A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation.

Nature communications

Wu J,Yang K,Cai S,Zhang X,Hu L,Lin F,Wu SQ,Xiao C,Liu WH,Han J

Mon Nov 28 00:00:00 EST 2022

Maggot treatment promotes healing of diabetic foot ulcer wounds possibly by upregulating Treg levels.

Diabetes research and clinical practice

Zhang J,Chen J,Gao C,Sun X,Wang L,Hu Z,Li G,Wang J,Wang A

Tue Feb 01 00:00:00 EST 2022

IRF-4 deficiency reduces inflammation and kidney fibrosis after folic acid-induced acute kidney injury.

International immunopharmacology

Chen M,Wen X,Gao Y,Liu B,Zhong C,Nie J,Liang H

Mon Nov 01 00:00:00 EDT 2021

IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhu X,Yao T,Wang R,Guo S,Wang X,Zhou Z,Zhang Y,Zhuo X,Wang R,Li JZ,Liu T,Kong X

Thu Oct 01 00:00:00 EDT 2020

Macrophage polarization and activation at the interface of multi-walled carbon nanotube-induced pulmonary inflammation and fibrosis.

Nanotoxicology

Dong J,Ma Q

Thu Mar 01 00:00:00 EST 2018

Macrophage polarization and activation at the interface of multi-walled carbon nanotube-induced pulmonary inflammation and fibrosis.

Nanotoxicology

Dong J,Ma Q

Thu Mar 01 00:00:00 EST 2018

MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression.

Mediators of inflammation

Jia A,Wang Y,Sun W,Xiao B,Wei Y,Qiu L,Mu L,Xu L,Li J,Zhang X,Liu D,Peng C,Zhang D,Xiang X

Mon May 21 00:00:00 EDT 2018

MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression.

Mediators of inflammation

Jia A,Wang Y,Sun W,Xiao B,Wei Y,Qiu L,Mu L,Xu L,Li J,Zhang X,Liu D,Peng C,Zhang D,Xiang X

Mon May 21 00:00:00 EDT 2018

MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression.

Mediators of inflammation

Jia A,Wang Y,Sun W,Xiao B,Wei Y,Qiu L,Mu L,Xu L,Li J,Zhang X,Liu D,Peng C,Zhang D,Xiang X

Mon May 21 00:00:00 EDT 2018

MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression.

Mediators of inflammation

Jia A,Wang Y,Sun W,Xiao B,Wei Y,Qiu L,Mu L,Xu L,Li J,Zhang X,Liu D,Peng C,Zhang D,Xiang X

Mon May 21 00:00:00 EDT 2018

Bioinformatics

Protein Aliases: Interferon regulatory factor 4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; Multiple myeloma oncogene 1; NF-EM5; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; Transcriptional activator PIP

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Gene Aliases: AI385587; IRF-4; IRF4; LSIRF; MUM1; NF-EM5; SHEP8; Spip

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UniProt ID: (Human) Q15306, (Mouse) Q64287

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Entrez Gene ID: (Human) 3662, (Mouse) 16364

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding protein-lysine N-methyltransferase activity sequence-specific DNA binding regulatory region DNA binding DNA binding winged helix/forkhead transcription factor

Process(es)

transcription from RNA polymerase II promoter peptidyl-lysine methylation negative regulation of toll-like receptor signaling pathway T cell activation defense response to protozoan myeloid dendritic cell differentiation positive regulation of DNA binding histone H3 acetylation histone H4 acetylation positive regulation of interleukin-10 biosynthetic process positive regulation of interleukin-2 biosynthetic process positive regulation of interleukin-13 biosynthetic process positive regulation of interleukin-4 biosynthetic process regulation of T-helper cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter interferon-gamma-mediated signaling pathway type I interferon signaling pathway T-helper 17 cell lineage commitment transcription, DNA-templated regulation of transcription, DNA-templated protein methylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MUM1/IRF4 Polyclonal Antibody

MUM1/IRF4 Antibody (11247-2-AP) in Flow

Product Details

11247-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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