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MURF1 Antibody (MA5-47051) in WB
Western blot analysis of MURF1 in Various tissue extracts (50 µg) separated by 10% SDS-PAGE. Membrane was blotted with MURF1 Monoclonal antibody (Product # MA5-47051) using a dilution of 1:1,000 followed by HRP-conjugated anti-rabbit IgG secondary antibody.
Product Details
MA5-47051
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL1450
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human MURF1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2938123
Product Specific Information
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
Target Information
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase TRIM63; FLJ32380; Iris RING finger protein; MURF 1; MURF-1; muscle ring finger protein 1; muscle specific ring finger protein 2; Muscle-specific RING finger protein 1; OTTHUMP00000008701; RING finger protein 28; RING-type E3 ubiquitin transferase TRIM63; RNF 28; Striated muscle RING zinc finger protein; TRIM 63; tripartite motif containing 63, E3 ubiquitin protein ligase; Tripartite motif-containing protein 63
Gene Aliases: IRF; MURF1; MURF2; RF1; RNF28; SMRZ; TRIM63
UniProt ID: (Human) Q969Q1
Entrez Gene ID: (Human) 84676, (Mouse) 433766
ubiquitin-protein transferase activity
signal transducer activity
protein binding
zinc ion binding
ligase activity
titin binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
ubiquitin protein ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
muscle contraction
signal transduction
skeletal muscle atrophy
response to electrical stimulus involved in regulation of muscle adaptation
protein ubiquitination
response to glucocorticoid
response to interleukin-1
regulation of gene expression
response to denervation involved in regulation of muscle adaptation
proteasome-mediated ubiquitin-dependent protein catabolic process
cellular response to dexamethasone stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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