Proteintech

MVP/LRP Polyclonal Antibody

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Antibody Testing Data (21)

MVP/LRP Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 21

MVP/LRP Antibody (16478-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using MVP antibody 16478-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

MVP/LRP Antibody in Immunohistochemistry (Paraffin) (IHC (P))

MVP/LRP Antibody in Immunoprecipitation (IP)

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Product Details

16478-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MVP/LRP Fusion Protein Ag9593 (544-893 aa encoded by BC015623)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: NWHFEVNDR KDPQETAKLF SVPDFVGDAC KAIASRVRGA VASVTFDDFH KNSARIIRTA VFGFETSEAK GPDGMALPRP RDQAVFPQNG LVVSSVDVQS VEPVDQRTRD ALQRSVQLAI EITTNSQEAA AKHEAQRLEQ EARGRLERQK ILDQSEAEKA RKELLELEAL SMAVESTGTA KAEAESRAEA ARIEGEGSVL QAKLKAQALA IETEAELQRV QKVRELELVY ARAQLELEVS KAQQLAEVEV KKFKQMTEAI GPSTIRDLAV AGPEMQVKLL QSLGLKSTLI TDGSTPINLF NTAFGLLGMG PEGQPLGRRV ASGPSPGEGI SPQSAQAPQA PGDNHVVPVL R (544-893 aa encoded by BC015623)

Target Information

This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CHD4 promotes acquired chemoresistance and tumor progression by activating the MEK/ERK axis.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Wu J,Zhou Z,Li J,Liu H,Zhang H,Zhang J,Huang W,He Y,Zhu S,Huo M,Liu M,Zhang C

Sun Jan 01 00:00:00 EST 2023

CHD4 promotes acquired chemoresistance and tumor progression by activating the MEK/ERK axis.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Wu J,Zhou Z,Li J,Liu H,Zhang H,Zhang J,Huang W,He Y,Zhu S,Huo M,Liu M,Zhang C

Sun Jan 01 00:00:00 EST 2023

CHD4 promotes acquired chemoresistance and tumor progression by activating the MEK/ERK axis.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Wu J,Zhou Z,Li J,Liu H,Zhang H,Zhang J,Huang W,He Y,Zhu S,Huo M,Liu M,Zhang C

Sun Jan 01 00:00:00 EST 2023

CHD4 promotes acquired chemoresistance and tumor progression by activating the MEK/ERK axis.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Wu J,Zhou Z,Li J,Liu H,Zhang H,Zhang J,Huang W,He Y,Zhu S,Huo M,Liu M,Zhang C

Sun Jan 01 00:00:00 EST 2023

Major Vault Protein (MVP) Associated With BRAF ^V600E Mutation Is an Immune Microenvironment-Related Biomarker Promoting the Progression of Papillary Thyroid Cancer via MAPK/ERK and PI3K/AKT Pathways.

Frontiers in cell and developmental biology

Dong X,Akuetteh PDP,Song J,Ni C,Jin C,Li H,Jiang W,Si Y,Zhang X,Zhang Q,Huang G

Fri Oct 20 00:00:00 EDT 2023

DEAD-box Helicase 27 Promotes Hepatocellular Carcinoma Progression Through ERK Signaling.

Technology in cancer research & treatment

Xiaoqian W,Bing Z,Yangwei L,Yafei Z,Tingting Z,Yi W,Qingjun L,Suxia L,Ling Z,Bo W,Peng Z

Tue Mar 08 00:00:00 EST 2022

DEAD-box Helicase 27 Promotes Hepatocellular Carcinoma Progression Through ERK Signaling.

Technology in cancer research & treatment

Xiaoqian W,Bing Z,Yangwei L,Yafei Z,Tingting Z,Yi W,Qingjun L,Suxia L,Ling Z,Bo W,Peng Z

Tue Mar 08 00:00:00 EST 2022

DEAD-box Helicase 27 Promotes Hepatocellular Carcinoma Progression Through ERK Signaling.

Technology in cancer research & treatment

Xiaoqian W,Bing Z,Yangwei L,Yafei Z,Tingting Z,Yi W,Qingjun L,Suxia L,Ling Z,Bo W,Peng Z

Tue Mar 08 00:00:00 EST 2022

DEAD-box Helicase 27 Promotes Hepatocellular Carcinoma Progression Through ERK Signaling.

Technology in cancer research & treatment

Xiaoqian W,Bing Z,Yangwei L,Yafei Z,Tingting Z,Yi W,Qingjun L,Suxia L,Ling Z,Bo W,Peng Z

Tue Mar 08 00:00:00 EST 2022

Differential RNA packaging into small extracellular vesicles by neurons and astrocytes.

Cell communication and signaling : CCS

Luo X,Jean-Toussaint R,Sacan A,Ajit SK

Sat Jul 10 00:00:00 EDT 2021

Structural and Functional Characterization of Fibronectin in Extracellular Vesicles From Hepatocytes.

Frontiers in cell and developmental biology

Li X,Chen R,Kemper S,Brigstock DR

Wed Apr 07 00:00:00 EDT 2021

The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity.

Cell

Simsek D,Tiu GC,Flynn RA,Byeon GW,Leppek K,Xu AF,Chang HY,Barna M

Thu Jun 01 00:00:00 EDT 2017

The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity.

Cell

Simsek D,Tiu GC,Flynn RA,Byeon GW,Leppek K,Xu AF,Chang HY,Barna M

Thu Jun 01 00:00:00 EDT 2017

MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression.

Nature communications

Teng Y,Ren Y,Hu X,Mu J,Samykutty A,Zhuang X,Deng Z,Kumar A,Zhang L,Merchant ML,Yan J,Miller DM,Zhang HG

Fri Feb 17 00:00:00 EST 2017

MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression.

Nature communications

Teng Y,Ren Y,Hu X,Mu J,Samykutty A,Zhuang X,Deng Z,Kumar A,Zhang L,Merchant ML,Yan J,Miller DM,Zhang HG

Fri Feb 17 00:00:00 EST 2017

Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.

Genetics and molecular research : GMR

Jiang YQ,Xu XP,Guo QM,Xu XC,Liu QY,An SH,Xu JL,Su F,Tai JB

Fri Sep 02 00:00:00 EDT 2016

Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.

Genetics and molecular research : GMR

Jiang YQ,Xu XP,Guo QM,Xu XC,Liu QY,An SH,Xu JL,Su F,Tai JB

Fri Sep 02 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: Lung resistance-related protein; Major vault protein; MVP; MVP1; Testicular Secretory Protein Li 30; VAULT1; vRNP

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Gene Aliases: 2310009M24Rik; LRP; MVP; VAULT1

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UniProt ID: (Human) Q14764, (Rat) Q62667, (Mouse) Q9EQK5

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Entrez Gene ID: (Human) 9961, (Rat) 64681, (Mouse) 78388

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Function(s)

protein binding protein kinase binding protein phosphatase binding scaffold/adaptor protein

Process(es)

protein transport negative regulation of signaling negative regulation of protein autophosphorylation ERBB signaling pathway mRNA transport negative regulation of protein tyrosine kinase activity cell proliferation protein activation cascade

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MVP/LRP Polyclonal Antibody

MVP/LRP Antibody (16478-1-AP) in ICC/IF

Product Details

16478-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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