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Product Details
MA5-26598
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI1F6
Immunogen
Human recombinant protein fragment corresponding to amino acids 2-261 of H2AFY2 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2724627
Target Information
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Core histone macro-H2A.2; core histone macroH2A2.2; H2A histone family, member Y2; Histone macroH2A2; histone mH2A2; mH2A2
Gene Aliases: H2AFY2; MACROH2A2
UniProt ID: (Human) Q9P0M6
Entrez Gene ID: (Human) 55506
negative regulation of transcription from RNA polymerase II promoter
regulation of cell growth
nucleosome assembly
chromatin silencing
brain development
dosage compensation
covalent chromatin modification
positive regulation of keratinocyte differentiation
negative regulation of gene expression, epigenetic
establishment of protein localization to chromatin
negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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