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Product Details
BS-1582R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Mannose-binding protein C, amino acids 31-130.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
MBL2 is a calcium-dependent lectin involved in innate immune defense. It binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. It also binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. MBL2 may bind DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Collectin-1; Collectin1; mannan-binding lectin; Mannan-binding protein; mannose binding lectin (C); mannose binding lectin 2 (protein C); mannose binding lectin, liver (C); Mannose-binding lectin; mannose-binding lectin (protein C) 2, soluble (opsonic defect); mannose-binding lectin 2, soluble (opsonic defect); Mannose-binding protein C; mannose-binding protein C (liver); MBP-C; MBP1; MBPC; MGC116832; MGC116833; RA-reactive factor P28A subunit; Ra-reactive factor polysaccharide-binding component p28A; RaRF p28A; RARF/P28A
Gene Aliases: Ab2-001; Ab2-011; COLEC1; HSMBPC; L-MBP; MBL; MBL-C; MBL2; MBL2D; MBP; MBP-C; MBP1; MBPD
UniProt ID: (Human) P11226, (Mouse) P41317, (Rat) P08661
Entrez Gene ID: (Human) 4153, (Mouse) 17195, (Rat) 64668
complement activation, lectin pathway
proteolysis
acute-phase response
complement activation
complement activation, classical pathway
response to oxidative stress
opsonization
defense response to bacterium
negative regulation of growth of symbiont in host
innate immune response
negative regulation of viral process
positive regulation of phagocytosis
defense response to Gram-positive bacterium
killing by host of symbiont cells
immune system process
positive regulation of protein processing
positive regulation of complement activation
protein oligomerization
protein homooligomerization
protein homotrimerization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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