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Mast Cell Chymase Antibody (PA5-97599) in WB
Western Blot analysis of Mast Cell Chymase using a Mast Cell Chymase Polyclonal antibody (Product # PA5-97599) at a concentration of 3 µg/mL. Positive WB detected in: MCF-7 whole cell lysate, Mouse spleen tissue, Mouse lung tissue, Mouse kidney tissue. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:50,000 dilution. Observed band size: 28 kDa.
Product Details
PA5-97599
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Chymase protein (22-247AA)
Conjugate
Form
Liquid
Concentration
3 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_2812214
Target Information
This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11. 2 in a cluster of genes encoding other proteases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-chymase; Chymase; chymase 1 preproprotein transcript E; chymase 1 preproprotein transcript I; chymase 1, mast cell; chymase, heart; chymase, mast cell; mast cell; Mast cell chymase 1; Mast cell protease 5; Mast cell protease I; mMCP-5
Gene Aliases: chymase; CMA1; CYH; CYM; Mcp-5; Mcp5; Mcpt5; MCT1; MMCP-5
UniProt ID: (Human) P23946, (Mouse) P21844
Entrez Gene ID: (Human) 1215, (Mouse) 17228
Performance Guarantee
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