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Invitrogen
Mast Cell Chymase Recombinant Rabbit Monoclonal Antibody (ARC0614)
FIGURE: 1 / 2
Mast Cell Chymase Antibody (MA5-35118) in IHC (P)
Immunohistochemistry analysis of Mast Cell Chymase in paraffin-embedded human appendix. Samples were incubated with Mast Cell Chymase Monoclonal antibody (Product # MA5-35118) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
MA5-35118
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC0614
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 148-247 of human Mast Cell Chymase (CMA1) (CMA1) (P23946)
Conjugate
Form
Liquid
Concentration
1.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2849023
Product Specific Information
Immunogen sequence: GWGRTGVLKP GSDTLQEVKL RLMDPQACSH FRDFDHNLQL CVGNPRKTKS AFKGDSGGPL LCAGVAQGIV SYGRSDAKPP AVFTRISHYR PWINQILQAN
Target Information
This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11. 2 in a cluster of genes encoding other proteases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-chymase; Chymase; chymase 1 preproprotein transcript E; chymase 1 preproprotein transcript I; chymase 1, mast cell; chymase, heart; chymase, mast cell; mast cell; Mast cell chymase 1; Mast cell protease 3; Mast cell protease 5; Mast cell protease I; Mast cell protease III; mMCP-5; rMCP-3; rMCP-5; rMCP-III
Gene Aliases: chymase; CMA1; CYH; CYM; Mcp-5; MCP3P; Mcp5; Mcpt3; Mcpt5; MCT1; MMCP-5
UniProt ID: (Human) P23946, (Rat) P50339, (Mouse) P21844
Entrez Gene ID: (Human) 1215, (Rat) 25627, (Mouse) 17228
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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