Invitrogen

Mast Cell Chymase Monoclonal Antibody (CC1)

Mast Cell Chymase Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Mast Cell Chymase Antibody (MA5-11717) in IHC (P)

Formalin-fixed, paraffin-embedded human tonsil stained with Mast Cell Chymase antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of mast cells.

Mast Cell Chymase Antibody in Immunocytochemistry (ICC/IF)

Mast Cell Chymase Antibody in Western Blot (WB)

Product Image Gallery

Product Details

MA5-11717

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:2,000

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Published species

Dog, Human, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

CC1

Immunogen

Purified human skin chymase

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10984248

Product Specific Information

MA5-11717 targets Mast Cell Chymase in IHC (P) and WB applications and shows reactivity with Human samples.

The MA5-11717 immunogen is purified human skin chymase.

Target Information

This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11. 2 in a cluster of genes encoding other proteases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Angiotensin AT2 receptor agonist prevents salt-sensitive hypertension in obese Zucker rats.

American journal of physiology. Renal physiology

Ali Q,Patel S,Hussain T

MA5-11717 was used in western blot to test if angiotensin type 2 receptor activation prevents high-sodium diet-induced hypertension in obese rats.

Mon Jun 15 00:00:00 EDT 2015

The role of macrophage migration inhibitory factor in mast cell-stimulated fibroblast proliferation and collagen production.

PloS one

Ningyan G,Xu Y,Hongfei S,Jingjing C,Min C

Published figure using Mast Cell Chymase monoclonal antibody (Product # MA5-11717) in Western Blot

Mon Mar 21 00:00:00 EDT 2016

The role of macrophage migration inhibitory factor in mast cell-stimulated fibroblast proliferation and collagen production.

PloS one

Ningyan G,Xu Y,Hongfei S,Jingjing C,Min C

Published figure using Mast Cell Chymase monoclonal antibody (Product # MA5-11717) in Western Blot

Mon Mar 21 00:00:00 EDT 2016

Hyperexpression of the high-affinity IgE receptor-beta chain in chronic allergic keratoconjunctivitis.

Investigative ophthalmology & visual science

Matsuda A,Okayama Y,Ebihara N,Yokoi N,Hamuro J,Walls AF,Ra C,Hopkin JM,Kinoshita S

MA5-11717 was used in immunohistochemistry to investigate the expression of high-affinity IgE receptor-beta chain in vivo

Mon Jun 01 00:00:00 EDT 2009

Cannabinoids reduce granuloma-associated angiogenesis in rats by controlling transcription and expression of mast cell protease-5.

British journal of pharmacology

De Filippis D,Russo A,D'Amico A,Esposito G,Pietropaolo C,Cinelli M,Russo G,Iuvone T

MA5-11717 was used in western blot to examine the effect of cannabinoids on rodent granuloma-associated angiogenesis

Fri Aug 01 00:00:00 EDT 2008

Interstitial Cajal-like cells in rat mesentery: an ultrastructural and immunohistochemical approach.

Journal of cellular and molecular medicine

Hinescu ME,Popescu LM,Gherghiceanu M,Faussone-Pellegrini MS

MA5-11717 was used in immunohistochemistry to characterize the interstitial Cajal-like cells in rat mesentery

Tue Jul 22 00:00:00 EDT 2008

Immediate anaphylactic death following antibiotics injection: splenic eosinophilia easily revealed by pagoda red stain.

Forensic science international

Trani N,Bonetti LR,Gualandri G,Barbolini G

MA5-11717 was used in immunohistochemistry to evaluate pagoda red stain for the forensic analysis of anaphylactic death

Sat Oct 25 00:00:00 EDT 2008

Identification of mast cells and mast cell subpopulations.

Methods in molecular medicine

Buckley M,Walls AF

MA5-11717 was used in immunohistochemistry to discuss methods for the detection of mast cells and mast cell subpopulations

Mon Aug 04 00:00:00 EDT 2008

Insights into the interstitium of ventricular myocardium: interstitial Cajal-like cells (ICLC).

Journal of cellular and molecular medicine

Popescu LM,Gherghiceanu M,Hinescu ME,Cretoiu D,Ceafalan L,Regalia T,Popescu AC,Ardeleanu C,Mandache E

MA5-11717 was used in immunohistochemistry to investigate the presence and role of interstitial Cajal-like cells in atrial myocardium

Fri Aug 18 00:00:00 EDT 2006

Anti-CXCR3 staining is useful for detecting human cutaneous and mucosal mast cells.

The Journal of dermatology

Fukiwake N,Moroi Y,Imafuku S,Masuda T,Kokuba H,Furue M,Urabe K

MA5-11717 was used in immunohistochemistry to study anti-CXCR3 staining for detecting human cutaneous and mucosal mast cells

Mon May 01 00:00:00 EDT 2006

c-Kit immunophenotyping and metalloproteinase expression profiles of mast cells in interstitial lung diseases.

The Journal of pathology

Edwards ST,Cruz AC,Donnelly S,Dazin PF,Schulman ES,Jones KD,Wolters PJ,Hoopes C,Dolganov GM,Fang KC

MA5-11717 was used in immunohistochemistry to study the expression of c-Kit and metalloproteinase by mast cells in interstitial lung diseases

Fri Jul 01 00:00:00 EDT 2005

Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors.

Veterinary pathology

Fernandez NJ,West KH,Jackson ML,Kidney BA

MA5-11717 was used in immunohistochemistry to study histochemical and immunohistochemical stains for differentiating canine cutaneous round cell tumors