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Product Details
BS-0027R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human MTR-1A, amino acids 201-280.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mel-1A-R; mel1a melatonin receptor; Mel1a receptor; Melatonin receptor type 1A
Gene Aliases: MEL-1A-R; MelR; MR; MT1; MTNR1A
UniProt ID: (Human) P48039, (Mouse) Q61184
Entrez Gene ID: (Human) 4543, (Mouse) 17773, (Rat) 114211
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
aging
mating behavior
circadian rhythm
positive regulation of cGMP biosynthetic process
camera-type eye development
negative regulation of insulin secretion
signal transduction
G-protein coupled receptor signaling pathway
Performance Guarantee
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