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FIGURE: 1 / 1
Melatonin Receptor 1A Antibody (BS-20768R) in WB
Lane 1:Mouse Cerebrum tissue lysates; Lane 2: Mouse Hippocampus tissue lysates; Lane 3: Mouse Spinal cord tissue lysates; Lane 4: Mouse Spinal cord tissue lysates ; Lane 5: Mouse Hippocampus tissue lysates probed with Melatonin Receptor 1A Polyclonal Antibody, Unconjugated (bs-20768R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min ... View More
Product Details
BS-20768R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Melatonin Receptor 1A (121-200).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA
Contains
0.1% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Target Information
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mel-1A-R; mel1a melatonin receptor; Mel1a receptor; Melatonin receptor type 1A
Gene Aliases: MEL-1A-R; MelR; MR; MT1; MTNR1A
UniProt ID: (Human) P48039, (Mouse) Q61184
Entrez Gene ID: (Human) 4543, (Mouse) 17773, (Rat) 114211
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
aging
mating behavior
circadian rhythm
positive regulation of cGMP biosynthetic process
camera-type eye development
negative regulation of insulin secretion
signal transduction
G-protein coupled receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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