Product References
Gut microbe-derived milnacipran enhances tolerance to gut ischemia/reperfusion injury.
Cell reports. Medicine
Deng F,Hu JJ,Lin ZB,Sun QS,Min Y,Zhao BC,Huang ZB,Zhang WJ,Huang WK,Liu WF,Li C,Liu KX
88-7772-72 was used in Flow Cytometry to suggest that gut microbiota affects susceptibility to I/R-induced enterogenic sepsis and that gut microbiota-derived MC plays a pivotal role in tolerance to intestinal I/R in an AHR/ILC3/IL-22 signaling-dependent manner, revealing the pathological mechanism, potential prevention and treatment drugs, and treatment strategies for intestinal I/R.
Tue Mar 21 00:00:00 EDT 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
88-7772-72 was used in Flow Cytometry to establish both direct and indirect roles for ILC2 in peri-aortic CaPO4 injury-induced mouse abdominal aortic aneurysms.
Wed Mar 01 00:00:00 EST 2023
Group 2 innate lymphoid cells protect mouse heart from myocardial infarction injury via interleukin 5, eosinophils, and dendritic cells.
Cardiovascular research
Liu T,Meng Z,Liu J,Li J,Zhang Y,Deng Z,Luo S,Wang M,Huang Q,Zhang S,Fendt P,Devouassoux J,Li D,McKenzie ANJ,Nahrendorf M,Libby P,Guo J,Shi GP
88-7772-72 was used in Flow cytometry/Cell sorting to reveal an indirect cardiac reparative role of ILC2 in post-MI hearts via the IL5, EOS, and DC mechanism.
Tue May 02 00:00:00 EDT 2023
Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration.
Nature communications
Lin C,Yang Q,Guo D,Xie J,Yang YS,Chaugule S,DeSouza N,Oh WT,Li R,Chen Z,John AA,Qiu Q,Zhu LJ,Greenblatt MB,Ghosh S,Li S,Gao G,Haynes C,Emerson CP,Shim JH
88-7772-72 was used in Flow cytometry/Cell sorting to identify mitochondrial oxidative phosphorylation as the prominent energy-driving force for osteogenesis of skeletal progenitors, governing musculoskeletal integrity.
Fri Nov 11 00:00:00 EST 2022
Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.
Nature communications
Liu N,He J,Fan D,Gu Y,Wang J,Li H,Zhu X,Du Y,Tian Y,Liu B,Fan Z
88-7772-72 was used in Flow cytometry/Cell sorting to study the role of circular RNA circTmem241 in group III innate lymphoid cell differentiation.
Thu Aug 11 00:00:00 EDT 2022
Acupoint Catgut-Embedding Therapy Inhibits NF-κB/COX-2 Pathway in an Ovalbumin-Induced Mouse Model of Allergic Asthma.
BioMed research international
Teng F,Ma X,Cui J,Zhu X,Tang W,Wang W,Wuniqiemu T,Qin J,Yi L,Zong Y,Liu C,Wang S
88-7772-72 was used in Flow cytometry/Cell sorting to show that ovalbumin induction resulted in a significant increase in airway resistance , accompanied by a significant decrease in lung dynamic compliance.
Fri Apr 08 00:00:00 EDT 2022
Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA.
Cellular & molecular immunology
Liu B,Liu N,Zhu X,Yang L,Ye B,Li H,Zhu P,Lu T,Tian Y,Fan Z
88-7772-72 was used in Immunocytochemistry-immunoflourescence to reveal an important role of circular RNA in the regulation of innate lymphoid cell homeostasis.
Tue Jun 01 00:00:00 EDT 2021
Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.
Nature communications
Lei H,Xu HZ,Shan HZ,Liu M,Lu Y,Fang ZX,Jin J,Jing B,Xiao XH,Gao SM,Gao FH,Xia L,Yang L,Liu LG,Wang WW,Liu CX,Tong Y,Wu YZ,Zheng JK,Chen GQ,Zhou L,Wu YL
88-7772-72 was used in Flow cytometry/Cell sorting to conclude that targeting USP47 is a promising strategy to overcome TKI resistance and eradicate leukemia stem/progenitor cells in CML.
Mon Jan 04 00:00:00 EST 2021
Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3.
Nature communications
Zheng Z,Li YN,Jia S,Zhu M,Cao L,Tao M,Jiang J,Zhan S,Chen Y,Gao PJ,Hu W,Wang Y,Shao C,Shi Y
88-7772-72 was used in Flow cytometry/Cell sorting to suggest that targeting the Th2-STAT6-C3-NETs cascade may reduce breast cancer metastasis to the lungs.
Wed Oct 27 00:00:00 EDT 2021
Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo.
Blood
Tarumoto Y,Lin S,Wang J,Milazzo JP,Xu Y,Lu B,Yang Z,Wei Y,Polyanskaya S,Wunderlich M,Gray NS,Stegmaier K,Vakoc CR
88-7772 was used in Flow cytometry/Cell sorting to evaluate whether inhibition of SIK3 with the tool compound YKL-05-099 can suppress MEF2C function and attenuate disease progression in animal models of acute myeloid leukemia.
Thu Jan 02 00:00:00 EST 2020
Site-1 protease ablation in the osterix-lineage in mice results in bone marrow neutrophilia and hematopoietic stem cell alterations.
Biology open
Patra D,Kim J,Zhang Q,Tycksen E,Sandell LJ
88-7772 was used in Flow cytometry/Cell sorting to show that S1P has a role in the lineage specification of hematopoietic stem cells and/or their progenitors for development of a normal hematopoietic niche.
Tue Jun 23 00:00:00 EDT 2020
An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution.
Nature communications
Liu B,Ye B,Zhu X,Yang L,Li H,Liu N,Zhu P,Lu T,He L,Tian Y,Fan Z
88-7772 was used in Flow cytometry/Cell sorting to support a function of the circRNA circKcnt2 in regulating ILC3 inactivation and resolution of innate colitis.
Fri Aug 14 00:00:00 EDT 2020
Gadofullerene nanoparticles for robust treatment of aplastic anemia induced by chemotherapy drugs.
Theranostics
Jia W,Zhen M,Li L,Zhou C,Sun Z,Liu S,Zhao Z,Li J,Wang C,Bai C
88-7772 was used in Flow cytometry/Cell sorting to provide an insight into the advanced nanoparticles to powerfully treat AA through ameliorating the erythrocyte maturation during erythropoiesis.
Tue May 18 00:00:00 EDT 2021
Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription.
The Journal of experimental medicine
Liu B,Yang L,Zhu X,Li H,Zhu P,Wu J,Lu T,He L,Liu N,Meng S,Zhou L,Ye B,Tian Y,Fan Z
88-7772 was used in Immunohistochemistry to show that the Yeats4-Lmo4 axis is required for ILC lineage commitment.
Mon Nov 04 00:00:00 EST 2019
Chemotherapeutic agent 5-fluorouracil increases survival of SOD1 mouse model of ALS.
PloS one
Rando A,de la Torre M,Martinez-Muriana A,Zaragoza P,Musaro A,Hernández S,Navarro X,Toivonen JM,Osta R
88-7772 was used in Flow cytometry/Cell sorting to study the effect of known stem cell mobilising agents and antimetabolite 5-fluorouracil in the SOD1G93A model of amyotrophic lateral sclerosis.
Fri Nov 01 00:00:00 EDT 2019
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
88-7772 was used in Flow cytometry/Cell sorting to study circular RNA-mediated maintenance of hematopoeitic stem cell homeostasis.
Tue Apr 17 00:00:00 EDT 2018
The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells.
Cell death & disease
Liu T,Kong WX,Tang XY,Xu M,Wang QH,Zhang B,Hu LD,Chen H
88-7772 was used in Flow cytometry/Cell sorting to identify Zfp90 as a key transcription factor in determining the fate of hematopoietic stem cells.
Thu Jun 07 00:00:00 EDT 2018
Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease.
The Journal of clinical investigation
Bruce DW,Stefanski HE,Vincent BG,Dant TA,Reisdorf S,Bommiasamy H,Serody DA,Wilson JE,McKinnon KP,Shlomchik WD,Armistead PM,Ting JPY,Woosley JT,Blazar BR,Zaiss DMW,McKenzie ANJ,Coghill JM,Serody JS
88-7772 was used in Flow cytometry/Cell sorting to assess the ability of donor type 2 innate lymphoid to ameliorate and prevent severe gastro-intestinal acute graft-versus-host disease.
Mon May 01 00:00:00 EDT 2017
Human umbilical cord blood-borne fibroblasts contain marrow niche precursors that form a bone/marrow organoid in vivo.
Development (Cambridge, England)
Pievani A,Sacchetti B,Corsi A,Rambaldi B,Donsante S,Scagliotti V,Vergani P,Remoli C,Biondi A,Robey PG,Riminucci M,Serafini M
88-7772 was used in Flow cytometry/Cell sorting to show that human umbilical cord blood-borne fibroblasts are able to recapitulate the conditions by which the bone marrow microenvironment is formed and establish complete hematopoietic stem cell niches.
Wed Mar 15 00:00:00 EDT 2017
Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2.
Nature communications
Ye B,Liu B,Yang L,Huang G,Hao L,Xia P,Wang S,Du Y,Qin X,Zhu P,Wu J,Sakaguchi N,Zhang J,Fan Z
88-7772 was used in Flow cytometry/Cell sorting to study how multipotent progenitors switch into common lymphoid progenitors or common myeloid progenitors during lymphoid lineage commitment.
Wed Nov 15 00:00:00 EST 2017
Serially Transplanted Nonpericytic CD146(-) Adipose Stromal/Stem Cells in Silk Bioscaffolds Regenerate Adipose Tissue In Vivo.
Stem cells (Dayton, Ohio)
Frazier TP,Bowles A,Lee S,Abbott R,Tucker HA,Kaplan D,Wang M,Strong A,Brown Q,He J,Bunnell BA,Gimble JM
88-7772 was used in Flow cytometry/Cell sorting to investigate whether adipose progenitors can be sorted based on the expression of CD146, CD34, and/or CD29, and when implanted in vivo these cells can persist, proliferate, and regenerate a functional fat pad over serial transplants.
Fri Apr 01 00:00:00 EDT 2016
Loss of bone marrow adrenergic beta 1 and 2 receptors modifies transcriptional networks, reduces circulating inflammatory factors, and regulates blood pressure.
Physiological genomics
Ahmari N,Schmidt JT,Krane GA,Malphurs W,Cunningham BE,Owen JL,Martyniuk CJ,Zubcevic J
88-7772 was used in Flow cytometry/Cell sorting to investigate the molecular and neural mechanisms underlying hypertension.
Fri Jul 01 00:00:00 EDT 2016
Partial Loss of Rpl11 in Adult Mice Recapitulates Diamond-Blackfan Anemia and Promotes Lymphomagenesis.
Cell reports
Morgado-Palacin L,Varetti G,Llanos S,Gómez-López G,Martinez D,Serrano M
88-7772 was used in Flow cytometry/Cell sorting to conclude that Rpl11-deficient mice recapitulate DBA disorder, including cancer predisposition.
Tue Oct 27 00:00:00 EDT 2015
Enhancer repertoires are reshaped independently of early priming and heterochromatin dynamics during B cell differentiation.
Nature communications
Choukrallah MA,Song S,Rolink AG,Burger L,Matthias P
88-7772 was used in Flow cytometry/Cell sorting to revisit the prevalent model about epigenetic reprogramming during hematopoiesis and give insights into the formation of gene regulatory networks.
Mon Oct 19 00:00:00 EDT 2015
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
Nature cell biology
Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF
88-7772 was used in Flow cytometry/Cell sorting to investigate the role of miR-126 and miR-126* in tumour progression.
Fri Mar 01 00:00:00 EST 2013
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.
Nature
Zuber J,Shi J,Wang E,Rappaport AR,Herrmann H,Sison EA,Magoon D,Qi J,Blatt K,Wunderlich M,Taylor MJ,Johns C,Chicas A,Mulloy JC,Kogan SC,Brown P,Valent P,Bradner JE,Lowe SW,Vakoc CR
88-7772 was used in Western Blotting to establish small-molecule inhibition of Brd4 as a promising therapeutic strategy in acute myeloid leukaemia.
Wed Aug 03 00:00:00 EDT 2011
