Invitrogen

Myeloperoxidase Monoclonal Antibody (4A4)

Product Details

MA1-20074

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

Immunohistochemistry (IHC)

View 11 publications 11 publications

ELISA (ELISA)

Assay-dependent

Affinity Purification (AP)

Assay-dependent

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

4A4

Immunogen

Purified, full length, native, human myeloperoxidase protein.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

4.6 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

4° C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_560236

Product Specific Information

MA1-20074 detects Myeloperoxidase in human samples.

Target Information

Myeloperoxidase (MPO) is a heme protein that is synthesized during myeloid differentiation and is a major component of neutrophil azurophilic granules. It is produced as a single chain precursor and subsequently cleaved into a light and heavy chain. The mature MPO is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme is responsible for producing hypohalous acids that are central to the microbicidal activity of neutrophils. Diseases that are associated with MPO include Myeloperoxidase Deficiency and Alzheimer's Disease, Familial, 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

In situ analysis of interleukin-23- and interleukin-12-positive cells in the spine of patients with ankylosing spondylitis.

Arthritis and rheumatism

Appel H,Maier R,Bleil J,Hempfing A,Loddenkemper C,Schlichting U,Syrbe U,Sieper J

MA1-20074 was used in immunohistochemistry to study the presence and source of IL-12 and IL-23 in patients with ankylosing spondylitis

Sat Jun 01 00:00:00 EDT 2013

Ligation of the jugular veins does not result in brain inflammation or demyelination in mice.

PloS one

Atkinson W,Forghani R,Wojtkiewicz GR,Pulli B,Iwamoto Y,Ueno T,Waterman P,Truelove J,Oklu R,Chen JW

MA1-20074 was used in immunohistochemistry to study whether chronic cerebrospinal venous insufficiency is a cause of multiple sclerosis using a murine model

Fri Aug 03 00:00:00 EDT 2012

Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kleijn A,Chen JW,Buhrman JS,Wojtkiewicz GR,Iwamoto Y,Lamfers ML,Stemmer-Rachamimov AO,Rabkin SD,Weissleder R,Martuza RL,Fulci G

MA1-20074 was used in immunohistochemistry to study the use of myeloperoxidase magnetic resonance imaging to differentiate inflammation from tumor/peritumor edema in gliomas

Fri Jul 01 00:00:00 EDT 2011

Tempol, a membrane-permeable radical scavenger, ameliorates lipopolysaccharide-induced acute lung injury in mice: a key role for superoxide anion.

European journal of pharmacology

El-Sayed NS,Mahran LG,Khattab MM

MA1-20074 was used in immunohistochemistry to study the mechanism by which a membrane-permeable radical scavenger protects against lipopolysaccharide-induced acute lung injury

Mon Aug 01 00:00:00 EDT 2011

Protective role of simvastatin on lung damage caused by burn and cotton smoke inhalation in rats.

The Journal of surgical research

Belli S,Basaran O,Ozdemir BH,Türkoğlu S,Karabay G,Kut A,Karakayali H,Haberal M

MA1-20074 was used in immunohistochemistry to study the effect of simvastatin lung injury caused by burn and smoke inhalation

Sun May 15 00:00:00 EDT 2011

Omega 3 fatty acids supplementation has an ameliorative effect in experimental ulcerative colitis despite increased colonic neutrophil infiltration.

Revista espanola de enfermedades digestivas

Varnalidis I,Ioannidis O,Karamanavi E,Ampas Z,Poutahidis T,Taitzoglou I,Paraskevas G,Botsios D

MA1-20074 was used in immunohistochemistry to study the efficacy of omega 3 fatty acids in the treatment of experimental ulcerative colitis

Sat Oct 01 00:00:00 EDT 2011

Hyperglycaemia but not hyperlipidaemia decreases serum amylase and increases neutrophils in the exocrine pancreas of cats.

Research in veterinary science

Zini E,Osto M,Moretti S,Franchini M,Kook PH,Lutz H,Guscetti F,Perren A,Hoelzle LE,Ackermann M,Lutz TA,Reusch CE

MA1-20074 was used in immunohistochemistry to study the effects of hyperglycaemia or hyperlipidaemia on the levels of serum amylase and neutrophils in the exocrine pancreas of cats

Sun Aug 01 00:00:00 EDT 2010

Caveolin-1 expression determines the route of neutrophil extravasation through skin microvasculature.

The American journal of pathology

Marmon S,Hinchey J,Oh P,Cammer M,de Almeida CJ,Gunther L,Raine CS,Lisanti MP

MA1-20074 was used in immunohistochemistry to investigate the role of caveolin-1 in the guidence of neutrophil transmigration

Sun Feb 01 00:00:00 EST 2009

Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense.

American journal of physiology. Gastrointestinal and liver physiology

Kao JY,Rathinavelu S,Eaton KA,Bai L,Zavros Y,Takami M,Pierzchala A,Merchant JL

MA1-20074 was used in immunohistochemistry to study the role of Helicobacter pylori-secreted factors in the inhibition of dendritic cell IL-12 secretion

Sat Jul 01 00:00:00 EDT 2006

Mechanisms of c-reactive protein up-regulation in arterialized vein grafts.

Surgery

Gulkarov I,Pintucci G,Bohmann K,Saunders PC,Sullivan RF,Ferrari G,Mignatti P,Galloway AC

MA1-20074 was used in immunohistochemistry to study the molecular basis of c-reactive protein up-regulation in arterialized vein grafts

Wed Feb 01 00:00:00 EST 2006

Biliary intervention augments chemotactic reaction and aggravates cholestatic liver injury in rats.

The Journal of surgical research

Chuang JH,Chang NK,Huang CC,Lo SK,Wang HC,Chen CM,Wu CL,Chou MH,Lin TK

MA1-20074 was used in immunohistochemistry to study the mechanism by which biliary intervention stimulates chemotactic responses and worsens liver damage in a rat model of cholestatic liver injury

Sun Aug 01 00:00:00 EDT 2004

Bioinformatics

Protein Aliases: MPO; Myeloperoxidase

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Gene Aliases: MPO

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UniProt ID: (Human) P05164

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Entrez Gene ID: (Human) 4353

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Function(s)

chromatin binding peroxidase activity heparin binding heme binding metal ion binding peroxidase

Process(es)

response to yeast hypochlorous acid biosynthetic process respiratory burst involved in defense response defense response response to oxidative stress aging response to mechanical stimulus removal of superoxide radicals response to food response to lipopolysaccharide low-density lipoprotein particle remodeling hydrogen peroxide catabolic process negative regulation of apoptotic process negative regulation of growth of symbiont in host defense response to fungus oxidation-reduction process response to gold nanoparticle

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Myeloperoxidase Monoclonal Antibody (4A4)

Product Details

MA1-20074

Western Blot (WB)

Immunohistochemistry (IHC)

ELISA (ELISA)

Affinity Purification (AP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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