Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-17526
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Fruit fly,
Human,
Mouse,
Non-human primate,
Rat,
Zebrafish
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Two synthetic peptides corresponding to two conserved regions of human N-Cadherin
Conjugate
Form
Liquid
Concentration
9 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10985390
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, neuronal; cadherin 2, type 1, N-cadherin (neuronal); Cadherin-2; Cadherin2; calcium-dependent adhesion protein, neuronal; CD325; CDw325; CDw325 antigen; cell adhesion molecule; glass onion; labyrinth; N-cadherin; N-cadherin 1; Neural cadherin; Parachute; ZNCAD
Gene Aliases: bib; CD325; CDH2; CDHN; CDw325; glo; lyr; N-cadherin; NCAD; pac; wu:fb47h04
UniProt ID: (Human) P19022, (Mouse) P15116, (Rat) Q9Z1Y3, (Zebrafish) Q90275
Entrez Gene ID: (Human) 1000, (Bovine) 281062, (Mouse) 12558, (Rat) 83501, (Zebrafish) 30291
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
glial cell differentiation
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell migration
cerebral cortex development
regulation of myelination
adherens junction organization
regulation of Rho protein signal transduction
positive regulation of MAPK cascade
cell-cell adhesion mediated by cadherin
blood vessel morphogenesis
brain morphogenesis
homeostasis of number of cells
regulation of axonogenesis
striated muscle cell differentiation
positive regulation of muscle cell differentiation
protein heterooligomerization
radial glial cell differentiation
neuroepithelial cell differentiation
regulation of oligodendrocyte progenitor proliferation
establishment of protein localization to plasma membrane
negative regulation of canonical Wnt signaling pathway
neuroligin clustering involved in postsynaptic membrane assembly
neuronal stem cell population maintenance
regulation of postsynaptic density protein 95 clustering
positive regulation of synaptic vesicle clustering
regulation of signal transduction
cell-cell adhesion
synapse assembly
single organismal cell-cell adhesion
regulation of protein localization
cell morphogenesis
cartilage condensation
neural crest cell migration
somitogenesis
neuron migration
neuron cell-cell adhesion
multicellular organism development
ectoderm development
nervous system development
axon guidance
axonal fasciculation
brain development
peripheral nervous system development
motor neuron axon guidance
cardioblast differentiation
spinal cord patterning
cell migration in hindbrain
hindbrain structural organization
ventricular system development
neural tube development
cell differentiation
midbrain development
hindbrain development
embryonic pectoral fin morphogenesis
dorsal fin morphogenesis
post-anal tail morphogenesis
tissue regeneration
odontogenesis
regulation of eye photoreceptor cell development
establishment of epithelial cell apical/basal polarity
embryonic eye morphogenesis
axial mesoderm structural organization
mesoderm morphogenesis
generation of neurons
semicircular canal morphogenesis
regulation of synaptic transmission, glutamatergic
dorsal convergence
retina development in camera-type eye
embryonic retina morphogenesis in camera-type eye
auditory receptor cell stereocilium organization
cilium morphogenesis
pigment cell development
sensory epithelium regeneration
commissural neuron axon guidance
cell migration involved in somitogenic axis elongation
motor neuron migration
cell-cell adhesion via plasma-membrane adhesion molecules
negative regulation of neural precursor cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support