Proteintech

N-cadherin Monoclonal Antibody (1D8B3)

N-cadherin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 15

N-cadherin Antibody (66219-1-IG) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Mouse heart tissue slide using (Product # 66219-1-Ig) N-cadherin antibody at dilution of 1:15,000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

N-cadherin Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

N-cadherin Antibody in Western Blot (WB)

Product Image Gallery

Product Details

66219-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:8,000

View 104 publications 104 publications

Immunohistochemistry (IHC)

View 13 publications 13 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 17 publications 17 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1D8B3

Immunogen

N-cadherin Fusion Protein Ag4996 (32-350 aa encoded by BC036470)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: CKTGFPEDV YSAVLSKDVH EGQPLLNVKF SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA KFLIYAQDKE TQEKWQVAVK LSLKPTLTEE SVKESAEVEE IVFPRQFSKH SGHLQRQKRD WVISPINLPE NSRGPFPQEL VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL NGMLRYRIVS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ (32-350 aa encoded by BC036470)

Target Information

N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Tue Jun 27 00:00:00 EDT 2023

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BioMed research international

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Tue Nov 22 00:00:00 EST 2022

Doxycycline Hydrochloride Regulates Cytoskeletal Rearrangement and Epithelial-To-Mesenchymal Transition in Malignant Rhabdoid Tumour of the Kidney.

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Doxycycline Hydrochloride Regulates Cytoskeletal Rearrangement and Epithelial-To-Mesenchymal Transition in Malignant Rhabdoid Tumour of the Kidney.

BioMed research international

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Tue Nov 22 00:00:00 EST 2022

Doxycycline Hydrochloride Regulates Cytoskeletal Rearrangement and Epithelial-To-Mesenchymal Transition in Malignant Rhabdoid Tumour of the Kidney.

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Cell death discovery

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Thu Nov 17 00:00:00 EST 2022

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Cell death discovery

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Tue Nov 01 00:00:00 EDT 2022

Cancer-associated fibroblasts promote the stemness and progression of renal cell carcinoma via exosomal miR-181d-5p.

Cell death discovery

Ding M,Zhao X,Chen X,Diao W,Kan Y,Cao W,Chen W,Jiang B,Qin H,Gao J,Zhuang J,Zhang Q,Guo H

Tue Nov 01 00:00:00 EDT 2022

Cancer-associated fibroblasts promote the stemness and progression of renal cell carcinoma via exosomal miR-181d-5p.

Cell death discovery

Ding M,Zhao X,Chen X,Diao W,Kan Y,Cao W,Chen W,Jiang B,Qin H,Gao J,Zhuang J,Zhang Q,Guo H

Tue Nov 01 00:00:00 EDT 2022

Cancer-associated fibroblasts promote the stemness and progression of renal cell carcinoma via exosomal miR-181d-5p.

Cell death discovery

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Tue Nov 01 00:00:00 EDT 2022

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International journal of biological sciences

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Thu Apr 14 00:00:00 EDT 2022

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Sat Jan 01 00:00:00 EST 2022

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Wed Jun 01 00:00:00 EDT 2022

Kinesin family member 23 exerts a protumor function in breast cancer via stimulation of the Wnt/β-catenin pathway.

Toxicology and applied pharmacology

He X,Wang J,Zhou R,Yu S,Jiang J,Zhou Q

Sat Jan 15 00:00:00 EST 2022

CLCA2 overexpression suppresses epithelial-to-mesenchymal transition in cervical cancer cells through inactivation of ERK/JNK/p38-MAPK signaling pathways.

BMC molecular and cell biology

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Tue Oct 25 00:00:00 EDT 2022

Desmoglein 2 can undergo Ca²⁺-dependent interactions with both desmosomal and classical cadherins including E-cadherin and N-cadherin.

Biophysical journal

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Tue Apr 05 00:00:00 EDT 2022

Extracellular Vesicles Carry lncRNA SNHG16 to Promote Metastasis of Breast Cancer Cells via the miR-892b/PPAPDC1A Axis.

Frontiers in cell and developmental biology

Xia W,Liu Y,Cheng T,Xu T,Dong M,Hu X

Tue Jul 13 00:00:00 EDT 2021

Extracellular Vesicles Carry lncRNA SNHG16 to Promote Metastasis of Breast Cancer Cells via the miR-892b/PPAPDC1A Axis.

Frontiers in cell and developmental biology

Xia W,Liu Y,Cheng T,Xu T,Dong M,Hu X

Tue Jul 13 00:00:00 EDT 2021

Gastrin-17 induces gastric cancer cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway.

Journal of physiology and biochemistry

Li Y,Zhao Y,Li Y,Zhang X,Li C,Long N,Chen X,Bao L,Zhou J,Xie Y

Mon Feb 01 00:00:00 EST 2021

TAp63α Is Involved in Tobacco Smoke-Induced Lung Cancer EMT and the Anti-cancer Activity of Curcumin via miR-19 Transcriptional Suppression.

Frontiers in cell and developmental biology

Xie C,Zhu J,Yang X,Huang C,Zhou L,Meng Z,Li X,Zhong C

Tue Mar 23 00:00:00 EDT 2021

Circular RNA circZFPM2 promotes epithelial-mesenchymal transition in endometriosis by regulating miR-205-5p/ZEB1 signalling pathway.

Cellular signalling

Wang D,Cui L,Yang Q,Wang J

Mon Nov 01 00:00:00 EDT 2021

Circular RNA circZFPM2 promotes epithelial-mesenchymal transition in endometriosis by regulating miR-205-5p/ZEB1 signalling pathway.

Cellular signalling

Wang D,Cui L,Yang Q,Wang J

Mon Nov 01 00:00:00 EDT 2021

HSD17B6 downregulation predicts poor prognosis and drives tumor progression via activating Akt signaling pathway in lung adenocarcinoma.

Cell death discovery

Tian T,Hong F,Wang Z,Hu J,Chen N,Lv L,Yi Q

Mon Nov 08 00:00:00 EST 2021

Expression of Talin-1 in endometriosis and its possible role in pathogenesis.

Reproductive biology and endocrinology : RB&E

Tang X,Li Q,Li L,Jiang J

Tue Mar 09 00:00:00 EST 2021

circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis.

Cell death discovery

Ma X,Ying Y,Sun J,Xie H,Li J,He L,Wang W,Chen S,Shen H,Yi J,Luo J,Wang X,Zheng X,Liu B,Xie L

Tue Nov 23 00:00:00 EST 2021

OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells.

Pathology, research and practice

Ge X,Peng X,Li M,Ji F,Chen J,Zhang D

Wed Sep 01 00:00:00 EDT 2021

Knockdown hsa_circ_0063526 inhibits endometriosis progression via regulating the miR-141-5p / EMT axis and downregulating estrogen receptors.

Aging

Wei Z,Hu Y,He X,Zhang M,Zhang X,Wang Y,Fang X,Li L

Thu Dec 30 00:00:00 EST 2021

Necroptosis pathway blockage attenuates PFKFB3 inhibitor-induced cell viability loss and genome instability in colorectal cancer cells.

American journal of cancer research

Yan S,Li Q,Zhang D,Wang X,Xu Y,Zhang C,Guo D,Bao Y

Tue Jun 08 00:00:00 EDT 2021

Pentamidine Inhibits Ovarian Cancer Cell Proliferation and Migration by Maintaining Stability of PTEN in vitro.

Drug design, development and therapy

Wu Y,Zhang Z,Kou Z

Wed Dec 08 00:00:00 EST 2021

Tumor-associated macrophages promote pancreatic ductal adenocarcinoma progression by inducing epithelial-to-mesenchymal transition.

Aging

Xiong C,Zhu Y,Xue M,Jiang Y,Zhong Y,Jiang L,Shi M,Chen H

Sun Jan 10 00:00:00 EST 2021

NLGN3 Upregulates Expression of ADAM10 to Promote the Cleavage of NLGN3 via Activating the LYN Pathway in Human Gliomas.

Frontiers in cell and developmental biology

Dang NN,Li XB,Zhang M,Han C,Fan XY,Huang SH

Tue Sep 07 00:00:00 EDT 2021

Tumor cell membrane-based peptide delivery system targeting the tumor microenvironment for cancer immunotherapy and diagnosis.

Acta biomaterialia

Meng X,Wang J,Zhou J,Tian Q,Qie B,Zhou G,Duan W,Zhu Y

Tue Jun 01 00:00:00 EDT 2021

MicroRNA-4423-3p inhibits proliferation of fibroblast-like synoviocytes by targeting matrix metalloproteinase 13 in rheumatoid arthritis.

Bioengineered

Xu W,Ye L,Wu H

Wed Dec 01 00:00:00 EST 2021

Long non-coding RNA GClnc1 knockdown suppresses progression of epithelial ovarian cancer by recruiting FOXC2 to disrupt the NOTCH1/NF-κB/Snail pathway.

Experimental cell research

Wu D,Ke Y,Xiao R,Liu J,Li Q,Wang Y

Mon Feb 01 00:00:00 EST 2021

The Gut Microbiota Activates AhR Through the Tryptophan Metabolite Kyn to Mediate Renal Cell Carcinoma Metastasis.

Frontiers in nutrition

Dai G,Chen X,He Y

Tue Aug 31 00:00:00 EDT 2021

miR-942-5p Inhibits Proliferation, Metastasis, and Epithelial-Mesenchymal Transition in Colorectal Cancer by Targeting CCBE1.

BioMed research international

Zhou L,Chen Q,Wu J,Yang J,Yin H,Tian J,Gong L,Kong D,Tao M

Mon May 31 00:00:00 EDT 2021

Tuftelin 1 (TUFT1) Promotes the Proliferation and Migration of Renal Cell Carcinoma via PI3K/AKT Signaling Pathway.

Pathology oncology research : POR

Lin H,Zeng W,Lei Y,Chen D,Nie Z

Mon Jan 03 00:00:00 EST 2022

LncRNA ABCC6P1 promotes proliferation and migration of papillary thyroid cancer cells via Wnt/β-catenin signaling pathway.

Annals of translational medicine

Guan Y,Li Y,Yang QB,Yu J,Qiao H

Thu Apr 01 00:00:00 EDT 2021

EFNA4 promotes cell proliferation and tumor metastasis in hepatocellular carcinoma through a PIK3R2/GSK3β/β-catenin positive feedback loop.

Molecular therapy. Nucleic acids

Lin J,Zeng C,Zhang J,Song Z,Qi N,Liu X,Zhang Z,Li A,Chen F

Fri Sep 03 00:00:00 EDT 2021

EFNA4 promotes cell proliferation and tumor metastasis in hepatocellular carcinoma through a PIK3R2/GSK3β/β-catenin positive feedback loop.

Molecular therapy. Nucleic acids

Lin J,Zeng C,Zhang J,Song Z,Qi N,Liu X,Zhang Z,Li A,Chen F

Fri Sep 03 00:00:00 EDT 2021

BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.

Journal of bone oncology

Guo H,Peng J,Hu J,Chang S,Liu H,Luo H,Chen X,Tang H,Chen Y

Wed Dec 01 00:00:00 EST 2021

FABP4 is an independent risk factor for lymph node metastasis and poor prognosis in patients with cervical cancer.

Cancer cell international

Li G,Wu Q,Gong L,Xu X,Cai J,Xu L,Zeng Y,He X,Wang Z

Tue Oct 26 00:00:00 EDT 2021

A Novel c-MET-Targeting Antibody-Drug Conjugate for Pancreatic Cancer.

Frontiers in oncology

Jin Y,Zhang Z,Zou S,Li F,Chen H,Peng C,Deng X,Wen C,Shen B,Zhan Q

Tue Apr 06 00:00:00 EDT 2021

CDKN2B antisense RNA 1 suppresses tumor growth in human colorectal cancer by targeting MAPK inactivator dual-specificity phosphatase 1.

Carcinogenesis

Pan J,Lin M,Xu Z,Xu M,Zhang J,Weng Z,Lin B,Lin X

Fri Nov 12 00:00:00 EST 2021

EPB41L5 promotes EMT through the ERK/p38 MAPK signaling pathway in esophageal squamous cell carcinoma.

Pathology, research and practice

Bao S,Ji Z,Shi M,Liu X

Wed Dec 01 00:00:00 EST 2021

EPB41L5 promotes EMT through the ERK/p38 MAPK signaling pathway in esophageal squamous cell carcinoma.

Pathology, research and practice

Bao S,Ji Z,Shi M,Liu X

Wed Dec 01 00:00:00 EST 2021

EPB41L5 promotes EMT through the ERK/p38 MAPK signaling pathway in esophageal squamous cell carcinoma.

Pathology, research and practice

Bao S,Ji Z,Shi M,Liu X

Wed Dec 01 00:00:00 EST 2021

EPB41L5 promotes EMT through the ERK/p38 MAPK signaling pathway in esophageal squamous cell carcinoma.

Pathology, research and practice

Bao S,Ji Z,Shi M,Liu X

Wed Dec 01 00:00:00 EST 2021

Advanced Maternal Age-associated SIRT1 Deficiency Compromises Trophoblast Epithelial-Mesenchymal Transition through an Increase in Vimentin Acetylation.

Aging cell

Xiong L,Ye X,Chen Z,Fu H,Li S,Xu P,Yu J,Wen L,Gao R,Fu Y,Qi H,Kilby MD,Saffery R,Baker PN,Tong C

Fri Oct 01 00:00:00 EDT 2021

Moderate oxidative stress promotes epithelial-mesenchymal transition in the lens epithelial cells via the TGF-β/Smad and Wnt/β-catenin pathways.

Molecular and cellular biochemistry

Chen X,Yan H,Chen Y,Li G,Bin Y,Zhou X

Mon Mar 01 00:00:00 EST 2021

miRNA-10a-5p inhibits cell metastasis in hepatocellular carcinoma via targeting SKA1.

The Kaohsiung journal of medical sciences

Shen D,Zhao HY,Gu AD,Wu YW,Weng YH,Li SJ,Song JY,Gu XF,Qiu J,Zhao W

Wed Sep 01 00:00:00 EDT 2021

DEPDC1B promotes migration and invasion in pancreatic ductal adenocarcinoma by activating the Akt/GSK3β/Snail pathway.

Oncology letters

Liu X,Li T,Huang X,Wu W,Li J,Wei L,Qian Y,Xu H,Wang Q,Wang L

Sun Nov 01 00:00:00 EDT 2020

CircATRNL1 promotes epithelial-mesenchymal transition in endometriosis by upregulating Yes-associated protein 1 in vitro.

Cell death & disease

Wang D,Luo Y,Wang G,Yang Q

Wed Jul 29 00:00:00 EDT 2020

CircATRNL1 promotes epithelial-mesenchymal transition in endometriosis by upregulating Yes-associated protein 1 in vitro.

Cell death & disease

Wang D,Luo Y,Wang G,Yang Q

Wed Jul 29 00:00:00 EDT 2020

GBP1 promotes erlotinib resistance via PGK1‑activated EMT signaling in non‑small cell lung cancer.

International journal of oncology

Cheng L,Gou L,Wei T,Zhang J

Tue Sep 01 00:00:00 EDT 2020

GBP1 promotes erlotinib resistance via PGK1‑activated EMT signaling in non‑small cell lung cancer.

International journal of oncology

Cheng L,Gou L,Wei T,Zhang J

Tue Sep 01 00:00:00 EDT 2020

AOC1 Contributes to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer.

Cancer management and research

Xu F,Xu Y,Xiong JH,Zhang JH,Wu J,Luo J,Xiong JP

Wed Apr 13 00:00:00 EDT 2022

EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis.

American journal of cancer research

Hu Y,Wei X,Lv Y,Xie X,Yang L,He J,Tao X,Ma Y,Su Y,Wu L,Fang W,Liu Z

Mon Sep 28 00:00:00 EDT 2020

TET1 may contribute to hypoxia-induced epithelial to mesenchymal transition of endometrial epithelial cells in endometriosis.

PeerJ

Wu J,Li X,Huang H,Xia X,Zhang M,Fang X

Sun Apr 17 00:00:00 EDT 2022

METTL3/YTHDF2 m⁶ A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer.

Journal of cellular and molecular medicine

Xie H,Li J,Ying Y,Yan H,Jin K,Ma X,He L,Xu X,Liu B,Wang X,Zheng X,Xie L

Wed Apr 01 00:00:00 EDT 2020

Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling.

Frontiers in oncology

Guo W,Zhang Z,Li G,Lai X,Gu R,Xu W,Chen H,Xing Z,Chen L,Qian J,Xu S,Zeng F,Deng F

Fri Oct 30 00:00:00 EDT 2020

YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer.

Molecular cancer

Li J,Xie H,Ying Y,Chen H,Yan H,He L,Xu M,Xu X,Liang Z,Liu B,Wang X,Zheng X,Xie L

Thu Oct 29 00:00:00 EDT 2020

Up-regulation of L Antigen Family Member 3 Associates With Aggressive Progression of Breast Cancer.

Frontiers in oncology

Dong X,Lv S,Gu D,Zhang X,Ye Z

Wed Feb 10 00:00:00 EST 2021

Sanguisorba officinalis L. Suppresses Triple-Negative Breast Cancer Metastasis by Inhibiting Late-Phase Autophagy via Hif-1α/Caveolin-1 Signaling.

Frontiers in pharmacology

Wang N,Muhetaer G,Zhang X,Yang B,Wang C,Zhang Y,Wang X,Zhang J,Wang S,Zheng Y,Zhang F,Wang Z

Mon Jan 24 00:00:00 EST 2022

Polydatin inhibits ZEB1-invoked epithelial-mesenchymal transition in fructose-induced liver fibrosis.

Journal of cellular and molecular medicine

Zhao X,Yang Y,Yu H,Wu W,Sun Y,Pan Y,Kong L

Sun Nov 01 00:00:00 EDT 2020

miR-145-5p suppresses proliferation, metastasis and EMT of colorectal cancer by targeting CDCA3.

Pathology, research and practice

Chen Q,Zhou L,Ye X,Tao M,Wu J

Wed Apr 01 00:00:00 EDT 2020

Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma.

DNA and cell biology

Zhang J,Chen Y,Lin J,Jia R,An T,Dong T,Zhang Y,Yang X

Sun Mar 01 00:00:00 EST 2020

The contrary functions of lncRNA HOTAIR/miR-17-5p/PTEN axis and Shenqifuzheng injection on chemosensitivity of gastric cancer cells.

Journal of cellular and molecular medicine

Jia J,Zhan D,Li J,Li Z,Li H,Qian J

Tue Jan 01 00:00:00 EST 2019

The contrary functions of lncRNA HOTAIR/miR-17-5p/PTEN axis and Shenqifuzheng injection on chemosensitivity of gastric cancer cells.

Journal of cellular and molecular medicine

Jia J,Zhan D,Li J,Li Z,Li H,Qian J

Tue Jan 01 00:00:00 EST 2019

Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3β/β-catenin signaling pathway.

EBioMedicine

Liu Y,Jiang Q,Liu X,Lin X,Tang Z,Liu C,Zhou J,Zhao M,Li X,Cheng Z,Li L,Xie Y,Liu Z,Fang W

Tue Oct 01 00:00:00 EDT 2019

EBioMedicine

Liu Y,Jiang Q,Liu X,Lin X,Tang Z,Liu C,Zhou J,Zhao M,Li X,Cheng Z,Li L,Xie Y,Liu Z,Fang W

Tue Oct 01 00:00:00 EDT 2019

Triptolide prevents proliferation and migration of Esophageal Squamous Cell Cancer via MAPK/ERK signaling pathway.

European journal of pharmacology

Yanchun M,Yi W,Lu W,Yu Q,Jian Y,Pengzhou K,Ting Y,Hongyi L,Fang W,Xiaolong C,Yongping C

Wed May 15 00:00:00 EDT 2019

VASN promotes YAP/TAZ and EMT pathway in thyroid carcinogenesis in vitro.

American journal of translational research

Bhandari A,Guan Y,Xia E,Huang Q,Chen Y

Thu Oct 01 00:00:00 EDT 2020

miR-196a-5p promotes metastasis of colorectal cancer via targeting IκBα.

BMC cancer

Xin H,Wang C,Liu Z

Tue Jan 08 00:00:00 EST 2019

miR-196a-5p promotes metastasis of colorectal cancer via targeting IκBα.

BMC cancer

Xin H,Wang C,Liu Z

Tue Jan 08 00:00:00 EST 2019

miR-196a-5p promotes metastasis of colorectal cancer via targeting IκBα.

BMC cancer

Xin H,Wang C,Liu Z

Tue Jan 08 00:00:00 EST 2019

miR-196a-5p promotes metastasis of colorectal cancer via targeting IκBα.

BMC cancer

Xin H,Wang C,Liu Z

Tue Jan 08 00:00:00 EST 2019

RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer.

Journal of experimental & clinical cancer research : CR

Li Q,Lai Q,He C,Fang Y,Yan Q,Zhang Y,Wang X,Gu C,Wang Y,Ye L,Han L,Lin X,Chen J,Cai J,Li A,Liu S

Thu Aug 01 00:00:00 EDT 2019

RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer.

Journal of experimental & clinical cancer research : CR

Li Q,Lai Q,He C,Fang Y,Yan Q,Zhang Y,Wang X,Gu C,Wang Y,Ye L,Han L,Lin X,Chen J,Cai J,Li A,Liu S

Thu Aug 01 00:00:00 EDT 2019

Lgl1 deficiency disrupts hippocampal development and impairs cognitive performance in mice.

Genes, brain, and behavior

Zhang T,Hou C,Zhang S,Liu S,Li Z,Gao J

Fri Nov 01 00:00:00 EDT 2019

Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.

The FEBS journal

Wang X,Yin L,Yang L,Zheng Y,Liu S,Yang J,Cui H,Wang H

Sun Dec 01 00:00:00 EST 2019

Krüppel-like Factor 4 Suppresses Serine/Threonine Kinase 33 Activation and Metastasis of Gastric Cancer through Reversing Epithelial-Mesenchymal Transition.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kong F,Sun T,Kong X,Xie D,Li Z,Xie K

Tue May 15 00:00:00 EDT 2018

Krüppel-like Factor 4 Suppresses Serine/Threonine Kinase 33 Activation and Metastasis of Gastric Cancer through Reversing Epithelial-Mesenchymal Transition.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kong F,Sun T,Kong X,Xie D,Li Z,Xie K

Tue May 15 00:00:00 EDT 2018

Nogo-B receptor promotes epithelial-mesenchymal transition in non-small cell lung cancer cells through the Ras/ERK/Snail1 pathway.

Cancer letters

Wu D,Zhao B,Qi X,Peng F,Fu H,Chi X,Miao QR,Shao S

Sun Apr 01 00:00:00 EDT 2018

Nogo-B receptor promotes epithelial-mesenchymal transition in non-small cell lung cancer cells through the Ras/ERK/Snail1 pathway.

Cancer letters

Wu D,Zhao B,Qi X,Peng F,Fu H,Chi X,Miao QR,Shao S

Sun Apr 01 00:00:00 EDT 2018

Increased expression of lncRNA SNHG12 predicts a poor prognosis of nasopharyngeal carcinoma and regulates cell proliferation and metastasis by modulating Notch signal pathway.

Cancer biomarkers : section A of Disease markers

Liu ZB,Tang C,Jin X,Liu SH,Pi W

Mon Apr 01 00:00:00 EDT 2019

Increased expression of lncRNA SNHG12 predicts a poor prognosis of nasopharyngeal carcinoma and regulates cell proliferation and metastasis by modulating Notch signal pathway.

Cancer biomarkers : section A of Disease markers

Liu ZB,Tang C,Jin X,Liu SH,Pi W

Mon Apr 01 00:00:00 EDT 2019

Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin β4/SNAI1/SIRT3 signaling pathway.

Oncogene

Wang S,Li J,Xie J,Liu F,Duan Y,Wu Y,Huang S,He X,Wang Z,Wu X

Sun Jul 01 00:00:00 EDT 2018

Sinomenine hydrochloride attenuates the proliferation, migration, invasiveness, angiogenesis and epithelial-mesenchymal transition of clear-cell renal cell carcinoma cells via targeting Smad in vitro.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhao B,Liu L,Mao J,Liu K,Fan W,Liu J,Zhang Z,Li Q

Fri Dec 01 00:00:00 EST 2017

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhao B,Liu L,Mao J,Liu K,Fan W,Liu J,Zhang Z,Li Q

Fri Dec 01 00:00:00 EST 2017

SphK1 modulates cell migration and EMT-related marker expression by regulating the expression of p-FAK in colorectal cancer cells.

International journal of molecular medicine

Xu CY,Liu SQ,Qin MB,Zhuge CF,Qin L,Qin N,Lai MY,Huang JA

Mon May 01 00:00:00 EDT 2017

SphK1 modulates cell migration and EMT-related marker expression by regulating the expression of p-FAK in colorectal cancer cells.

International journal of molecular medicine

Xu CY,Liu SQ,Qin MB,Zhuge CF,Qin L,Qin N,Lai MY,Huang JA

Mon May 01 00:00:00 EDT 2017

In vitro anticancer activities of osthole against renal cell carcinoma cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Liu L,Mao J,Wang Q,Zhang Z,Wu G,Tang Q,Zhao B,Li L,Li Q

Sun Oct 01 00:00:00 EDT 2017

In vitro anticancer activities of osthole against renal cell carcinoma cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Liu L,Mao J,Wang Q,Zhang Z,Wu G,Tang Q,Zhao B,Li L,Li Q

Sun Oct 01 00:00:00 EDT 2017

Long non-coding RNA NEAT1 regulates epithelial membrane protein 2 expression to repress nasopharyngeal carcinoma migration and irradiation-resistance through miR-101-3p as a competing endogenous RNA mechanism.

Oncotarget

Wang Y,Wang C,Chen C,Wu F,Shen P,Zhang P,He G,Li X

Tue Sep 19 00:00:00 EDT 2017

Oncotarget

Wang Y,Wang C,Chen C,Wu F,Shen P,Zhang P,He G,Li X

Tue Sep 19 00:00:00 EDT 2017

Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice.

Scientific reports

Zhang J,Liu Z,Zhang T,Lin Z,Li Z,Zhang A,Sun X,Gao J

Tue Sep 20 00:00:00 EDT 2016

Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice.

Scientific reports

Zhang J,Liu Z,Zhang T,Lin Z,Li Z,Zhang A,Sun X,Gao J

Tue Sep 20 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); Cadherin-2; Cadherin2; calcium-dependent adhesion protein, neuronal; CD325; CDw325; CDw325 antigen; N-cadherin; N-cadherin 1; Neural cadherin

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Gene Aliases: CD325; CDH2; CDHN; CDw325; N-cadherin; NCAD

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UniProt ID: (Human) P19022, (Mouse) P15116, (Rat) Q9Z1Y3

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Entrez Gene ID: (Pig) 100515322, (Human) 1000, (Mouse) 12558, (Rat) 83501

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Function(s)

calcium ion binding protein binding beta-catenin binding protein kinase binding protein phosphatase binding protein complex binding alpha-catenin binding gamma-catenin binding nitric-oxide synthase binding enzyme binding metal ion binding cadherin

Process(es)

cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules glial cell differentiation calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell migration cerebral cortex development regulation of myelination adherens junction organization regulation of Rho protein signal transduction positive regulation of MAPK cascade cell-cell adhesion mediated by cadherin blood vessel morphogenesis brain morphogenesis homeostasis of number of cells regulation of axonogenesis striated muscle cell differentiation positive regulation of muscle cell differentiation protein heterooligomerization radial glial cell differentiation neuroepithelial cell differentiation regulation of oligodendrocyte progenitor proliferation establishment of protein localization to plasma membrane negative regulation of canonical Wnt signaling pathway neuroligin clustering involved in postsynaptic membrane assembly neuronal stem cell population maintenance regulation of postsynaptic density protein 95 clustering positive regulation of synaptic vesicle clustering synapse assembly regulation of signal transduction single organismal cell-cell adhesion regulation of protein localization

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N-cadherin Monoclonal Antibody (1D8B3)

N-cadherin Antibody (66219-1-IG) in IHC (P)

Product Details

66219-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

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Type

Clone

Immunogen

Conjugate

Form

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Purification

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