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Product Details
PA5-42832
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the C-terminal of human NCAPD2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2607791
Product Specific Information
Peptide sequence: KAIIDEFEQK LRACHTRGLD GIKELEIGQA GSQRAPSAKK PSTGSRYQPL
Sequence homology: Dog: 79%; Horse: 93%; Human: 100%; Pig: 92%; Rabbit: 92%
Target Information
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chromosome condensation related SMC associated protein 1; Chromosome condensation-related SMC-associated protein 1; Chromosome-associated protein D2; Condensin complex subunit 1; hCAP-D2; Non-SMC condensin I complex subunit D2; non-SMC condensin I complex, subunit D2; XCAP-D2 homolog
Gene Aliases: CAP-D2; CAPD2; CNAP1; hCAP-D2; KIAA0159; NCAPD2
UniProt ID: (Human) Q15021
Entrez Gene ID: (Human) 9918
Performance Guarantee
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