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Immunogen sequence: MEDVEARFA HLLQPIRDLT KNWEVDVAAQ LGEYLEELDQ ICISFDEGKT TMNFIEAALL IQGSACVYSK KVEYLYSLVY QALDFISGKR RAKQLSSVQE DRANGVASSG VPQEAENEFL SLDDFPDSRT NVDLKNDQTP SEVLIIPLLP MALVAPDEME KNNNPLYSRQ GEVLASRKDF RMNTCVPHPR GAFMLEPEGM SPMEPAGVSP MPGTQKDTGR TEEQPMEVSV CRSPVPALGF SQEPGPSPEG PMPLGGGEDE DAEEAVELPE ASAPKAALEP KESRSPQQSA ALPRRYMLRE REGAPEPASC VKETPDPWQS LDPFDSLESK PFKKGRPYSV PPCVEEALGQ K (1-350 aa encoded by BC001298)
Structural maintenance of chromosomes (SMC) and non-SMC condensin proteins associate into complexes that have been implicated in the process of chromosome condensation. A crucial prerequisite for accurate segregation of replicated sister chromatids is the condensation of the chromosomes into a manageable form prior to metaphase. The condensin I complex consists of two SMC subunits, SMC2 and SMC4, and three non-SMC subunits, CAP-H, CAP-G, and CAP-D2. An alternative complex, the condensin II complex, contains alternate non-SMC subunits, CAP-G2, CAP-H2, and CAP-D3. CAP-H2 is also known as Non-SMC condensin II complex, subunit H2 (NCAPH2) or kleisin beta isoform 2. The three non-SMC subunits in the condensing complexes form a regulatory subcomplex that is required to activate the SMC ATPases and to promote mitosis-specific chromatin binding of the holocomplex. The precise individual functions of each non-SMC protein in activation remain to be determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CAP-H2 subunit of the condensin II complex; Chromosome-associated protein H2; Condensin-2 complex subunit H2; CTA-384D8.36; hCAP-H2; kleisin beta; Kleisin-beta; Non-SMC condensin II complex subunit H2; non-SMC condensin II complex, subunit H2
Gene Aliases: CAPH2; D15Ertd785e; NCAPH2
UniProt ID: (Human) Q6IBW4, (Mouse) Q8BSP2
Entrez Gene ID: (Human) 29781, (Mouse) 52683
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