Bethyl Laboratories

NCoR Polyclonal Antibody

View all (11) NCoR1 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

A301-145A

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:10,000
-

Immunoprecipitation (IP)

2-10 µg/mg lysate
-

ChIP-sequencing (ChIP-Seq)

2 µg
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 1525 and 1575 of human nuclear receptor co-repressor 1.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.20 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

TBS, pH 7.0 to 8.0, with 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Wet ice

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: h KIAA1047; hCIT529I10; MGC104216; N-CoR; N-CoR1; nuclear receptor corepressor; Nuclear receptor corepressor 1; protein phosphatase 1, regulatory subunit 109; retinoid X receptor interacting protein 13; retinoid X receptor-interacting protein 13; thyroid hormone- and retinoic acid receptor-associated corepressor 1

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Gene Aliases: 5730405M06Rik; A230020K14Rik; hN-CoR; KIAA1047; mKIAA1047; N-CoR; N-CoR1; NCOR1; PPP1R109; RIP13; Rxrip13; TRAC1

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UniProt ID: (Human) O75376

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Entrez Gene ID: (Human) 9611, (Mouse) 20185

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Function(s)
RNA polymerase II regulatory region DNA binding RNA polymerase II activating transcription factor binding chromatin binding transcription corepressor activity protein binding ligand-dependent nuclear receptor binding protein domain specific binding estrogen receptor binding nuclear hormone receptor binding histone deacetylase binding peroxisome proliferator activated receptor binding transcription regulatory region DNA binding retinoid X receptor binding thyroid hormone receptor binding DNA binding transcription factor activity, sequence-specific DNA binding histone deacetylase regulator activity retinoic acid receptor binding sequence-specific DNA binding chromatin/chromatin-binding, or -regulatory protein
Process(es)
negative regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter skeletal muscle tissue development lactation circadian rhythm positive regulation of cell proliferation covalent chromatin modification cerebellum development cellular lipid metabolic process negative regulation of JNK cascade spindle assembly regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter negative regulation of production of miRNAs involved in gene silencing by miRNA regulation of fatty acid transport CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter negative regulation of gene expression negative regulation of phosphatidylinositol 3-kinase signaling chromatin modification thalamus development regulation of histone deacetylation positive regulation of histone deacetylation circadian regulation of gene expression regulation of multicellular organism growth cholesterol homeostasis negative regulation of transcription, DNA-templated regulation of catalytic activity definitive erythrocyte differentiation
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