Proteintech

NEIL1 Polyclonal Antibody

FIGURE: 1 / 3

NEIL1 Antibody (12145-1-AP) in WB

MCF-7 cells were subjected to SDS PAGE followed by western blot with 12145-1-AP (NEIL1 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

Product Image Gallery

Product Details

12145-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

Assay-dependent

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NEIL1 Fusion Protein Ag2793 (1-390 aa encoded by BC010876)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPEGPELHL ASQFVNEACR ALVFGGCVEK SSVSRNPEVP FESSAYRISA SARGKELRLI LSPLPGAQPQ QEPLALVFRF GMSGSFQLVP REELPRHAHL RFYTAPPGPR LALCFVDIRR FGRWDLGGKW QPGRGPCVLQ EYQQFRENVL RNLADKAFDR PICEALLDQR FFNGIGNYLR AEILYRLKIP PFEKARSVLE ALQQHRPSPE LTLSQKIRTK LQNPDLLELC HSVPKEVVQL GGRGYGSESG EEDFAAFRAW LRCYGMPGMS SLQDRHGRTI WFQGDPGPLA PKGRKSRKKK SKATQLSPED RVEDALPPSK APSRTRRAKR DLPKRTATQR PEGTSLQQDP EAPTVPKKGR RKGRQAASGH CRPRKVKADI PSLEPEGTSA S (1-390 aa encoded by BC010876)

Target Information

NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

DNA-Protein Cross-Linking Sequencing for Genome-Wide Mapping of Thymidine Glycol.

Journal of the American Chemical Society

Tang F,Yuan J,Yuan BF,Wang Y

Wed Jan 12 00:00:00 EST 2022

Breakage of cytoplasmic chromosomes by pathological DNA base excision repair.

Nature

Tang S,Stokasimov E,Cui Y,Pellman D

Wed Jun 01 00:00:00 EDT 2022

Novel interaction interfaces mediate the interaction between the NEIL1 DNA glycosylase and mitochondrial transcription factor A.

Frontiers in cell and developmental biology

Sharma N,Thompson MK,Arrington JF,Terry DM,Chakravarthy S,Prevelige PE,Prakash A

Tue Jan 31 00:00:00 EST 2023

Mono- and biallelic germline variants of DNA glycosylase genes in colon adenomatous polyposis families from two continents.

Frontiers in oncology

Olkinuora AP,Mayordomo AC,Kauppinen AK,Cerliani MB,Coraglio M,Collia ÁK,Gutiérrez A,Alvarez K,Cassana A,Lopéz-Köstner F,Jauk F,García-Rivello H,Ristimäki A,Koskenvuo L,Lepistö A,Nieminen TT,Vaccaro CA,Pavicic WH,Peltomäki P

Fri Nov 18 00:00:00 EST 2022

Cervical carcinoma risk associate with genetic polymorphisms of NEIL2 gene in Chinese population and its significance as predictive biomarker.

Scientific reports

Ye F,Liu J,Wang H,Chen X,Cheng Q,Chen H

Fri Mar 20 00:00:00 EDT 2020

Nei Endonuclease VIII-Like1 (NEIL1) Inhibits Apoptosis of Human Colorectal Cancer Cells.

BioMed research international

Xue W,Liu Y,Xin N,Miao J,Du J,Wang Y,Shi H,Wei Y,Zhang H,Chen Y,Gao Y,Li D,Feng Y,Yan J,Zhang J,Hou N,Huang C,Han J

Fri Apr 16 00:00:00 EDT 2021

Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair.

DNA repair

Quiñones JL,Thapar U,Wilson SH,Ramsden DA,Demple B

Sun Mar 01 00:00:00 EST 2020

Validating the concept of mutational signatures with isogenic cell models.

Nature communications

Zou X,Owusu M,Harris R,Jackson SP,Loizou JI,Nik-Zainal S

Tue May 01 00:00:00 EDT 2018

Validating the concept of mutational signatures with isogenic cell models.

Nature communications

Zou X,Owusu M,Harris R,Jackson SP,Loizou JI,Nik-Zainal S

Tue May 01 00:00:00 EDT 2018

Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity.

Toxicology and applied pharmacology

Ma H,Wang J,Abdel-Rahman SZ,Hazra TK,Boor PJ,Khan MF

Tue Feb 15 00:00:00 EST 2011

Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity.

Toxicology and applied pharmacology

Ma H,Wang J,Abdel-Rahman SZ,Hazra TK,Boor PJ,Khan MF

Tue Feb 15 00:00:00 EST 2011

Bioinformatics

Protein Aliases: DNA endonuclease eight-like glycosylase 1; DNA glycosylase/AP lyase Neil1; DNA-(apurinic or apyrimidinic site) lyase Neil1; Endonuclease 8-like 1; endonuclease VIII; Endonuclease VIII-like 1; FLJ22402; FPG1; NEH1; nei endonuclease VIII-like 1; Nei homolog 1; nei-like DNA glycosylase 1; Nei-like protein 1

View more View less

Gene Aliases: 2810450N13Rik; FPG1; hFPG1; NEI1; NEIL1

View more View less

UniProt ID: (Human) Q96FI4, (Mouse) Q8K4Q6

View more View less

Entrez Gene ID: (Human) 79661, (Rat) 367090, (Mouse) 72774

View more View less

Function(s)

damaged DNA binding DNA-(apurinic or apyrimidinic site) lyase activity protein C-terminus binding zinc ion binding hydrolase activity, acting on glycosyl bonds DNA N-glycosylase activity lyase activity purine-specific mismatch base pair DNA N-glycosylase activity nucleic acid binding DNA binding catalytic activity uracil DNA N-glycosylase activity hydrolase activity hydrolase activity, hydrolyzing N-glycosyl compounds single-strand selective uracil DNA N-glycosylase activity DNA-3-methylbase glycosylase activity nicotinamide riboside hydrolase activity nicotinic acid riboside hydrolase activity deoxyribonucleoside 5'-monophosphate N-glycosidase activity DNA glycosylase

Process(es)

base-excision repair nucleotide-excision repair response to oxidative stress negative regulation of nuclease activity depyrimidination DNA catabolic process, endonucleolytic DNA repair cellular response to DNA damage stimulus metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

NEIL1 Polyclonal Antibody

NEIL1 Antibody (12145-1-AP) in WB

Product Details

12145-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!