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Product Details
H00010783-M02
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2A7
Immunogen
NEK6 (AAH00101, 1 a.a. approximately 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MAGQPGHMPH GGSSNNLCHT LGPVHPPDPQ RHPNTLSFRC SLADFQIEKK IGRGQFSEVY KATCLLDRKT VALKKVQIFE MMDAKARQDC VKEIGLLKQV
Target Information
NEK6 kinase is a member of the NEK family. NEK6 is a serine/threonine kinase that controls the initiation of mitosis and is required for the metaphase-anaphase transition. The Aspergillus nidulans 'never in mitosis A' (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform functions similar to those of NIMA. NEK6 encodes a NEK type protein kinase, which contains a C-terminal NIMA-like catalytic domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Never in mitosis A-related kinase 6; NIMA (never in mitosis gene a)-related kinase 6; NIMA-related kinase 6; NimA-related protein kinase 6; Protein kinase SID6-1512; putative serine-threonine protein kinase; RP11-101K10.6; Serine/threonine-protein kinase Nek6; SID
Gene Aliases: NEK6; SID6-1512
UniProt ID: (Human) Q9HC98
Entrez Gene ID: (Human) 10783
cytokinesis
protein phosphorylation
apoptotic process
chromosome segregation
mitotic nuclear division
mitotic nuclear envelope disassembly
signal transduction
regulation of mitotic cell cycle
peptidyl-serine phosphorylation
regulation of mitotic metaphase/anaphase transition
G2 DNA damage checkpoint
positive regulation of I-kappaB kinase/NF-kappaB signaling
protein autophosphorylation
spindle assembly
regulation of cellular senescence
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