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NEUROD1 Polyclonal Antibody

NEUROD1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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NEUROD1 Antibody (12081-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Mouse brain tissue slide using (Product # 12081-1-AP) NEUROD1 antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

NEUROD1 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

NEUROD1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12081-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NEUROD1 Fusion Protein Ag2713 (1-356 aa encoded by BC009046)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.47 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MTKSYSESG LMGEPQPQGP PSWTDECLSS QDEEHEADKK EDDLEAMNAE EDSLRNGGEE EDEDEDLEEE EEEEEEDDDQ KPKRRGPKKK KMTKARLERF KLRRMKANAR ERNRMHGLNA ALDNLRKVVP CYSKTQKLSK IETLRLAKNY IWALSEILRS GKSPDLVSFV QTLCKGLSQP TTNLVAGCLQ LNPRTFLPEQ NQDMPPHLPT ASASFPVHPY SYQSPGLPSP PYGTMDSSHV FHVKPPPHAY SAALEPFFES PLTDCTSPSF DGPLSPPLSI NGNFSFKHEP SAEFEKNYAF TMHYPAATLA GAQSHGSIFS GTAAPRCEIP IDNIMSFDSH SHHERVMSAQ LNAIFHD (1-356 aa encoded by BC009046)

Target Information

NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6). MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

NEUROD1 predicts better prognosis in pancreatic cancer revealed by a TILs-based prognostic signature.

Frontiers in pharmacology

Jiang Z,Pan J,Lu J,Mei J,Xu R,Xia D,Yang X,Wang H,Liu C,Xu J,Ding J

Wed Nov 02 00:00:00 EDT 2022

Loss of BAF (mSWI/SNF) chromatin-remodeling ATPase Brg1 causes multiple malformations of cortical development in mice.

Human molecular genetics

Jin Y,Gao X,Lu M,Chen G,Yang X,Ren N,Song Y,Hou C,Li J,Liu Q,Gao J

Mon Oct 10 00:00:00 EDT 2022

Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration.

Science advances

Welch GM,Boix CA,Schmauch E,Davila-Velderrain J,Victor MB,Dileep V,Bozzelli PL,Su Q,Cheng JD,Lee A,Leary NS,Pfenning AR,Kellis M,Tsai LH

Fri Sep 30 00:00:00 EDT 2022

Three-dimensional cell-culture platform based on hydrogel with tunable microenvironmental properties to improve insulin-secreting function of MIN6 cells.

Biomaterials

Zhang M,Yan S,Xu X,Yu T,Guo Z,Ma M,Zhang Y,Gu Z,Feng Y,Du C,Wan M,Hu K,Han X,Gu N

Mon Mar 01 00:00:00 EST 2021

Prototypical oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer.

Science advances

Patel AS,Yoo S,Kong R,Sato T,Sinha A,Karam S,Bao L,Fridrikh M,Emoto K,Nudelman G,Powell CA,Beasley MB,Zhu J,Watanabe H

Fri Jan 01 00:00:00 EST 2021

Centrioles are amplified in cycling progenitors of olfactory sensory neurons.

PLoS biology

Ching K,Stearns T

Tue Sep 01 00:00:00 EDT 2020

Exploration of gastric neuroendocrine carcinoma (GNEC) specific signaling pathways involved in chemoresistance via transcriptome and in vitro analysis.

Computational and structural biotechnology journal

Xie J,Chen P,Xie H,Sun Y,Huang Z,Wei R,Miao Z,Wang Q,Zhang SD,Wong KH,Lin Y,Huang C,Kwok HF

Sat Oct 10 00:00:00 EDT 2020

Exploration of gastric neuroendocrine carcinoma (GNEC) specific signaling pathways involved in chemoresistance via transcriptome and in vitro analysis.

Computational and structural biotechnology journal

Xie J,Chen P,Xie H,Sun Y,Huang Z,Wei R,Miao Z,Wang Q,Zhang SD,Wong KH,Lin Y,Huang C,Kwok HF

Sat Oct 10 00:00:00 EDT 2020

CHD8 dosage regulates transcription in pluripotency and early murine neural differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Sood S,Weber CM,Hodges HC,Krokhotin A,Shalizi A,Crabtree GR

Tue Sep 08 00:00:00 EDT 2020

Tumor Heterogeneity Underlies Differential Cisplatin Sensitivity in Mouse Models of Small-Cell Lung Cancer.

Cell reports

Böttger F,Semenova EA,Song JY,Ferone G,van der Vliet J,Cozijnsen M,Bhaskaran R,Bombardelli L,Piersma SR,Pham TV,Jimenez CR,Berns A

Tue Jun 11 00:00:00 EDT 2019

Pioglitazone Ameliorates Atorvastatin-Induced Islet Cell Dysfunction through Activation of FFA1 in INS-1 Cells.

Journal of diabetes research

Zhu K,Qian L,Lin Y,An L,Mu G,Ma G,Ren L

Fri Jul 26 00:00:00 EDT 2019

EGF suppresses the expression of miR-124a in pancreatic β cell lines via ETS2 activation through the MEK and PI3K signaling pathways.

International journal of biological sciences

Yang L,Zhu Y,Kong D,Gong J,Yu W,Liang Y,Nie Y,Teng CB

Mon Jul 06 00:00:00 EDT 2020

Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells.

Scientific reports

Chen C,Ma Q,Liu C,Deng P,Zhu G,Zhang L,He M,Lu Y,Duan W,Pei L,Li M,Yu Z,Zhou Z

Thu May 29 00:00:00 EDT 2014

Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells.

Scientific reports

Chen C,Ma Q,Liu C,Deng P,Zhu G,Zhang L,He M,Lu Y,Duan W,Pei L,Li M,Yu Z,Zhou Z

Thu May 29 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: Basic helix-loop-helix factor 1; basic helix-loop-helix transcription factor; beta-cell E-box transactivator 2; Beta-cell E-box transcriptional activator 2; Beta2; BHF-1; BHF1; bHLHa3; Class A basic helix-loop-helix protein 3; neuro d1; NeuroD; NeuroD1; neurogenic differentiation 1; Neurogenic differentiation factor 1; neurogenic helix-loop-helix protein NEUROD

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Gene Aliases: BETA2; BHF-1; BHLHA3; MODY6; NEUROD; NEUROD1

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UniProt ID: (Human) Q13562, (Rat) Q64289, (Mouse) Q60867

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Entrez Gene ID: (Human) 4760, (Rat) 29458, (Mouse) 18012

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding transcription factor binding sequence-specific DNA binding protein heterodimerization activity E-box binding DNA binding double-stranded DNA binding protein dimerization activity basic helix-loop-helix transcription factor

Process(es)

pancreatic A cell fate commitment pancreatic PP cell fate commitment transcription from RNA polymerase II promoter nucleocytoplasmic transport nitric oxide mediated signal transduction response to glucose anterior/posterior pattern specification dentate gyrus development cerebellum development neurogenesis signal transduction involved in regulation of gene expression insulin secretion endocrine pancreas development amacrine cell differentiation enteroendocrine cell differentiation response to drug glucose homeostasis positive regulation of apoptotic process positive regulation of cell differentiation positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JAK-STAT cascade embryonic organ morphogenesis neuron development inner ear development regulation of insulin secretion positive regulation of sequence-specific DNA binding transcription factor activity regulation of intestinal epithelial structure maintenance regulation of cell cycle arrest cellular response to glucose stimulus negative regulation of type B pancreatic cell apoptotic process positive regulation of transcription regulatory region DNA binding transcription, DNA-templated hindbrain development camera-type eye development cell fate commitment regulation of neuron differentiation regulation of transcription, DNA-templated multicellular organism development nervous system development cell differentiation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NEUROD1 Polyclonal Antibody

NEUROD1 Antibody (12081-1-AP) in IHC (P)

Product Details

12081-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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