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Product Details
PA5-85708
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human Neurofibromin.
Conjugate
Form
Liquid
Concentration
0.88 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2792847
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (98%), Rat (100%).
Positive Control: A431.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686J1293; FLJ21220; Neurofibromatosis-related protein NF-1; Neurofibromin
Gene Aliases: NF1; NFNS; VRNF; WSS
UniProt ID: (Human) P21359
Entrez Gene ID: (Human) 4763
MAPK cascade
osteoblast differentiation
metanephros development
response to hypoxia
liver development
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
regulation of cell-matrix adhesion
negative regulation of cell-matrix adhesion
negative regulation of protein kinase activity
cell communication
Ras protein signal transduction
negative regulation of neuroblast proliferation
brain development
peripheral nervous system development
heart development
skeletal muscle tissue development
visual learning
extrinsic apoptotic signaling pathway via death domain receptors
regulation of gene expression
Schwann cell development
phosphatidylinositol 3-kinase signaling
negative regulation of angiogenesis
spinal cord development
amygdala development
forebrain astrocyte development
neural tube development
cerebral cortex development
myelination in peripheral nervous system
actin cytoskeleton organization
extracellular matrix organization
collagen fibril organization
adrenal gland development
negative regulation of cell migration
regulation of synaptic transmission, GABAergic
cellular response to heat
negative regulation of Rac protein signal transduction
wound healing
negative regulation of transcription factor import into nucleus
positive regulation of apoptotic process
regulation of GTPase activity
negative regulation of MAP kinase activity
negative regulation of MAPK cascade
pigmentation
positive regulation of neuron apoptotic process
regulation of blood vessel endothelial cell migration
positive regulation of GTPase activity
regulation of bone resorption
negative regulation of osteoclast differentiation
regulation of glial cell differentiation
positive regulation of adenylate cyclase activity
regulation of angiogenesis
negative regulation of Ras protein signal transduction
negative regulation of neurotransmitter secretion
negative regulation of fibroblast proliferation
regulation of long-term neuronal synaptic plasticity
sympathetic nervous system development
camera-type eye morphogenesis
negative regulation of astrocyte differentiation
negative regulation of oligodendrocyte differentiation
smooth muscle tissue development
artery morphogenesis
forebrain morphogenesis
cognition
gamma-aminobutyric acid secretion, neurotransmission
glutamate secretion, neurotransmission
observational learning
regulation of long-term synaptic potentiation
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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