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Product Details
H00004771-B02P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NF2 (NP_861968.1, 1 a.a. approximately 507 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEVK KQILDEKIYC PPEASVLLAS YAVQAKYGDY DPSVHKRGFL AQEELLPKRV INLYQMTPEM WEERITAWYA EHRGRARDEA EMEYLKIAQD LEMYGVNYFA IRNKKGTELL LGVDALGLHI YDPENRLTPK ISFPWNEIRN ISYSDKEFTI KPLDKKIDVF KFNSSKLRVN KLILQLCIGN HDLFMRRRKA DSLEVQQMKA QAREEKARKQ MERQRLAREK QMREEAERTR DELERRLLQM KEEATMANEA LMRSEETADL LAEKAQITEE EAKLLAQKAA EAEQEMQRIK ATAIRTEEEK RLMEQKVLEA EVLALKMAEE SERRAKEADQ LKQDLQEARE AERRAKQKLL EIATKPTYPP MNPIPAPLPP DIPSFNLIGD SLSFDFKDTD MKRLSMEIEK EKVEYMEKSK HLQEQLNELK TEIEALKLKE RETALDILHN ENSDRGGSSK HNTIKKPQAQ GRRPICI
Target Information
NF2 encodes a protein, Merlin, that is similar to some members of the ERM family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. Merlin has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Merlin; MGC123124; moesin-ezrin-radixin like; Moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromin 2 (bilateral acoustic neuroma); neurofibromin 2 (merlin); Neurofibromin-2; OTTHUMP00000199607; Schwannomerlin; Schwannomin
Gene Aliases: ACN; BANF; NF2; SCH
UniProt ID: (Human) P35240
Entrez Gene ID: (Human) 4771
mesoderm formation
negative regulation of cell-matrix adhesion
negative regulation of protein kinase activity
ectoderm development
negative regulation of DNA replication
negative regulation of cell proliferation
Schwann cell proliferation
regulation of gliogenesis
hippocampus development
negative regulation of cell-cell adhesion
actin cytoskeleton organization
negative regulation of cell growth
negative regulation of cell migration
regulation of protein stability
regulation of hippo signaling
odontogenesis of dentin-containing tooth
negative regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of tyrosine phosphorylation of Stat5 protein
negative regulation of MAPK cascade
cell-cell junction organization
positive regulation of cell differentiation
negative regulation of JAK-STAT cascade
positive regulation of stress fiber assembly
lens fiber cell differentiation
regulation of stem cell proliferation
regulation of protein localization to nucleus
regulation of neural precursor cell proliferation
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