Proteintech

NFATC2 Polyclonal Antibody

NFATC2 Antibody in Immunocytochemistry (ICC/IF)

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NFATC2 Antibody (22023-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed U-251 cells using NFATC2 antibody (Product # 22023-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

NFATC2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

NFATC2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

22023-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 7 publications 7 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NFATC2 Fusion Protein Ag16849 (1-302 aa encoded by BC136418)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.54 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MNAPERQPQ PDGGDAPGHE PGGSPQDELD FSILFDYEYL NPNEEEPNAH KVASPPSGPA YPDDVLDYGL KPYSPLASLS GEPPGRFGEP DRVGPQKFLS AAKPAGASGL SPRIEITPSH ELIQAVGPLR MRDAGLLVEQ PPLAGVAASP RFTLPVPGFE GYREPLCLSP ASSGSSASFI SDTFSPYTSP CVSPNNGGPD DLCPQFQNIP AHYSPRTSPI MSPRTSLAED SCLGRHSPVP RPASRSSSPG AKRRHSCAEA LVALPPGASP QRSRSPSPQP SSHVAPQDHG SPAGYPPVAG SAV (1-302 aa encoded by BC136418)

Target Information

The nuclear factor of activated T-cells (NFAT) transcription complex is required for the expression of a group of proteins that collectively regulate the immune response. Four NFAT proteins, encoded on separate genes and expressed as several splice variants, have been described: NFAT1 (also known as NFATp or NFATc2), NFAT2 (NFATc or NFATc1), NFAT3, and NFAT4 (NFATx or NFATc3). These proteins show a low level of sequence similarity with the Dorsal/Rel/NFkB family of transcription factors. Another NFAT-related protein termed NFAT5 differs from isoforms 1-4 in that it lacks many of the Fos/Jun contact sites observed in its predecessors and its subcellular localization is not calcineurin-dependent.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The circular RNA circHelz enhances cardiac fibrosis by facilitating the nuclear translocation of YAP1.

Translational research : the journal of laboratory and clinical medicine

Pang P,Si W,Wu H,Wang C,Liu K,Jia Y,Zhang Z,Zhang F,Kong X,Yang Y,Jiang W,Song J,Zeng L,Xiong Y,Lian J,Wang N,Bian Y,Yang B

Sat Jul 01 00:00:00 EDT 2023

miR-26a-5p alleviates CFA-induced chronic inflammatory hyperalgesia through Wnt5a/CaMKII/NFAT signaling in mice.

CNS neuroscience & therapeutics

Lu Y,Liu M,Guo X,Wang P,Zeng F,Wang H,Tang J,Qin Z,Tao T

Mon May 01 00:00:00 EDT 2023

Role of nuclear factor of activated T Cells-1 in Sepsis-induced behavioral deficits in mice.

Brain research

Jiang F,Guo Y,Hu L,Zhang M,Meng J,Si Y,Shi H

Mon May 01 00:00:00 EDT 2023

Ryanodine receptor 2 promotes colorectal cancer metastasis by the ROS/BACH1 axis.

Molecular oncology

Chen T,Zhang X,Ding X,Feng J,Zhang X,Xie D,Wang X

Sat Apr 01 00:00:00 EDT 2023

SOCE-mediated NFAT1-NOX2-NLRP1 inflammasome involves in lipopolysaccharide-induced neuronal damage and Aβ generation.

Molecular neurobiology

Sun Z,Li X,Yang L,Dong X,Han Y,Li Y,Luo J,Li W

Sun May 01 00:00:00 EDT 2022

SOCE-mediated NFAT1-NOX2-NLRP1 inflammasome involves in lipopolysaccharide-induced neuronal damage and Aβ generation.

Molecular neurobiology

Sun Z,Li X,Yang L,Dong X,Han Y,Li Y,Luo J,Li W

Sun May 01 00:00:00 EDT 2022

Human PMSCs-derived small extracellular vesicles alleviate neuropathic pain through miR-26a-5p/Wnt5a in SNI mice model.

Journal of neuroinflammation

Lu Y,Zhang J,Zeng F,Wang P,Guo X,Wang H,Qin Z,Tao T

Wed Sep 07 00:00:00 EDT 2022

Targeted regulation of lymphocytic ER stress response with an overall immunosuppression to alleviate allograft rejection.

Biomaterials

Shi Y,Lu Y,Zhu C,Luo Z,Li X,Liu Y,Jiang M,Liu X,Luo L,Du Y,You J

Sat May 01 00:00:00 EDT 2021

Targeted regulation of lymphocytic ER stress response with an overall immunosuppression to alleviate allograft rejection.

Biomaterials

Shi Y,Lu Y,Zhu C,Luo Z,Li X,Liu Y,Jiang M,Liu X,Luo L,Du Y,You J

Sat May 01 00:00:00 EDT 2021

ANKRD22 Drives Rapid Proliferation of Lgr5⁺ Cells and Acts as a Promising Therapeutic Target in Gastric Mucosal Injury.

Cellular and molecular gastroenterology and hepatology

Liu J,Wu J,Wang R,Zhong D,Qiu Y,Wang H,Song Z,Zhu Y

Fri Mar 25 00:00:00 EDT 2022

ANKRD22 Drives Rapid Proliferation of Lgr5⁺ Cells and Acts as a Promising Therapeutic Target in Gastric Mucosal Injury.

Cellular and molecular gastroenterology and hepatology

Liu J,Wu J,Wang R,Zhong D,Qiu Y,Wang H,Song Z,Zhu Y

Fri Mar 25 00:00:00 EDT 2022

NFAT Overexpression Correlates with CA72-4 and Poor Prognosis of Ovarian Clear-Cell Carcinoma Subtype.

Reproductive sciences (Thousand Oaks, Calif.)

Xin B,Ji KQ,Liu YS,Zhao XD

Mon Mar 01 00:00:00 EST 2021

Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes.

Journal of diabetes research

Wang Q,Tian X,Zhou W,Wang Y,Zhao H,Li J,Zhou X,Zhang H,Zhao T,Li P

Mon Aug 23 00:00:00 EDT 2021

IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation.

Mucosal immunology

Hu J,Gao N,Zhang Y,Chen X,Li J,Bian F,Chi W,Liu Z,de Paiva CS,Pflugfelder SC,Li DQ

Sun Nov 01 00:00:00 EDT 2020

Disruption of Plin5 degradation by CMA causes lipid homeostasis imbalance in NAFLD.

Liver international : official journal of the International Association for the Study of the Liver

Ma SY,Sun KS,Zhang M,Zhou X,Zheng XH,Tian SY,Liu YS,Chen L,Gao X,Ye J,Zhou XM,Wang JB,Han Y

Thu Oct 01 00:00:00 EDT 2020

Inhibition of RELM-β prevents hypoxia-induced overproliferation of human pulmonary artery smooth muscle cells by reversing PLC-mediated KCNK3 decline.

Life sciences

Han L,Song N,Hu X,Zhu A,Wei X,Liu J,Yuan S,Mao W,Chen X

Wed Apr 01 00:00:00 EDT 2020

Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis.

Breast cancer research : BCR

Miao Y,Shen Q,Zhang S,Huang H,Meng X,Zheng X,Yao Z,He Z,Lu S,Cai C,Zou F

Thu Aug 29 00:00:00 EDT 2019

Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis.

Breast cancer research : BCR

Miao Y,Shen Q,Zhang S,Huang H,Meng X,Zheng X,Yao Z,He Z,Lu S,Cai C,Zou F

Thu Aug 29 00:00:00 EDT 2019

Inhibition of MCF-7 breast cancer cell proliferation by a synthetic peptide derived from the C-terminal sequence of Orai channel.

Biochemical and biophysical research communications

Li S,Yao M,Niu C,Liu D,Tang Z,Gu C,Zhao H,Ke J,Wu S,Wang X,Wu F

Tue Sep 03 00:00:00 EDT 2019

miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2.

Cell death & disease

Zhang X,Wang C,Zhao J,Xu J,Geng Y,Dai L,Huang Y,Fu SC,Dai K,Zhang X

Thu Apr 06 00:00:00 EDT 2017

miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2.

Cell death & disease

Zhang X,Wang C,Zhao J,Xu J,Geng Y,Dai L,Huang Y,Fu SC,Dai K,Zhang X

Thu Apr 06 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: IB-IXL; KIAA0611; NF-ATc2; NF-ATp; NFAT pre-existing s; NFAT pre-existing subunit; NFAT transcription complex, preexisting component; Nuclear factor of activated T-cells, cytoplasmic 2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; nuclear factor of activated T-cells, preexisting component; OTTHUMP00000031291; preexisting nuclear factor of activated T-cells 2; T cell transcription factor NFAT1; T-cell transcription factor NFAT1

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Gene Aliases: AI607462; NF-ATc2; NF-ATp; NFAT1; NFAT1-D; NFATC2; NFATP

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UniProt ID: (Human) Q13469, (Mouse) Q60591

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Entrez Gene ID: (Human) 4773, (Mouse) 18019

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding Rel homology transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter cytokine production regulation of transcription, DNA-templated transcription from RNA polymerase II promoter cellular response to DNA damage stimulus myotube cell development cell migration positive regulation of B cell proliferation calcineurin-NFAT signaling cascade Fc-epsilon receptor signaling pathway response to drug positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter B cell receptor signaling pathway positive regulation of myoblast fusion transcription, DNA-templated positive regulation of gene expression

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NFATC2 Polyclonal Antibody

NFATC2 Antibody (22023-1-AP) in ICC/IF

Product Details

22023-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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