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NFKB1 p105/p50 Polyclonal Antibody

NFKB1 p105/p50 Antibody in Western Blot (WB)

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NFKB1 p105/p50 Antibody (15506-1-AP) in WB

Jurkat cells were subjected to SDS PAGE followed by western blot with 15506-1-AP (NFKB1,p105,p50-Specific antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours.

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Product Details

15506-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 15 publications 15 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can bind both p105 and p50 isoforms of NFKB1.

Target Information

NF-kB is a nuclear transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, in injury, and by bacterial and viral products. It is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis and inflammation. NFKB1 (p50), a 50KDa functional sub-unit of NF-kB, is a member of Rel protein family. It is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing nuclear localization signal, DNA-binding and dimerization domains. NFKB1 (p50) forms homodimers or heterodimerizes with p65, forming the functional NF-kB factor. NFKB1 (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-bidning. Pathological role of NF-kB has been suggested in AIDS, hematogenic cancer cell metastasis and rheumatoid arthritis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Chinese herbal formula, modified Xianfang Huoming Yin, alleviates the inflammatory proliferation of rat synoviocytes induced by IL-1β through regulating the migration and differentiation of T lymphocytes.

Journal of ethnopharmacology

Li D,Liu W,Sun S,Zhang Y,Zhang P,Feng G,Wei J,Chai L

Mon Jun 12 00:00:00 EDT 2023

Syndecan-3 Coregulates Milk Fat Metabolism and Inflammatory Reactions in Bovine Mammary Epithelial Cells through AMPK/SIRT1 Signaling Pathway.

International journal of molecular sciences

Fan J,Zhao Z,Wu H,Fang X,Miao F,Chen X,Jiang X,Li J,Jiang P,Yu H

Mon Apr 03 00:00:00 EDT 2023

Interleukin-1 increases cyclooxygenase-2 expression and prostaglandin E2 production in human granulosa-lutein cell via nuclear factor kappa B/P65 and extracellular signal-regulated kinase 1/2 signaling pathways.

Molecular and cellular endocrinology

Wan S,Chen Q,Xiang Y,Sang Y,Tang M,Song Y,Feng G,Ye B,Bai L,Zhu Y

Mon May 01 00:00:00 EDT 2023

Chip-DSF: A rapid screening strategy for drug protein targets.

Pharmacological research

Cui Z,Chen P,Li C,Deng S,Yang H

Mon Aug 01 00:00:00 EDT 2022

EB1089 promotes the expression of vitamin D receptor in the intestinal epithelial cell line HT-29 and reduces lipopolysaccharide-induced inflammatory response.

Annals of translational medicine

Lu D,Yu M,Chen L,Ye J,Huang L,Zhu G,Lan B

Fri Apr 01 00:00:00 EDT 2022

Identification of PDCD2 as a Candidate Target of Andrographolide That Arrests the Tumor Cell Cycle by Human Proteome-Scale Screening.

ACS pharmacology & translational science

Wang L,Li C,Chen P,Liu C,Cui Z,Deng S,Yang H

Fri Jul 08 00:00:00 EDT 2022

l-Arginine prevents 4-hydroxy-2-nonenal accumulation and depresses inflammation via inhibiting NF-κB activation.

Journal of biochemical and molecular toxicology

Liang M,Wang Z,Li H,Liu B,Yang L

Mon Aug 01 00:00:00 EDT 2022

Reduced inhibition underlies early life LPS exposure induced-cognitive impairment: Prevention by environmental enrichment.

International immunopharmacology

Wu XM,Ji MH,Yin XY,Gu HW,Zhu TT,Wang RZ,Yang JJ,Shen JC

Fri Jul 01 00:00:00 EDT 2022

Baicalein Delays H₂O₂-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism.

ACS chemical neuroscience

Gao L,Zheng WG,Wu XK,Du GH,Qin XM

Wed Jul 07 00:00:00 EDT 2021

Ophiocordyceps lanpingensis polysaccharides alleviate chronic kidney disease through MAPK/NF-κB pathway.

Journal of ethnopharmacology

Zhou S,He Y,Zhang W,Xiong Y,Jiang L,Wang J,Cui X,Qu Y,Ge F

Tue Aug 10 00:00:00 EDT 2021

Gastric Electrical Pacing Reduces Apoptosis of Interstitial Cells of Cajal via Antioxidative Stress Effect Attributing to Phenotypic Polarization of M2 Macrophages in Diabetic Rats.

Oxidative medicine and cellular longevity

Wang H,Zhao K,Ba Y,Gao T,Shi N,Niu Q,Liu C,Chen Y

Thu May 20 00:00:00 EDT 2021

Gastric Electrical Pacing Reduces Apoptosis of Interstitial Cells of Cajal via Antioxidative Stress Effect Attributing to Phenotypic Polarization of M2 Macrophages in Diabetic Rats.

Oxidative medicine and cellular longevity

Wang H,Zhao K,Ba Y,Gao T,Shi N,Niu Q,Liu C,Chen Y

Thu May 20 00:00:00 EDT 2021

Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways.

Planta medica

Zeng Q,Zeng Y,Nie X,Guo Y,Zhan Y

Tue Dec 01 00:00:00 EST 2020

S100A14 suppresses metastasis of nasopharyngeal carcinoma by inhibition of NF-kB signaling through degradation of IRAK1.

Oncogene

Meng DF,Sun R,Liu GY,Peng LX,Zheng LS,Xie P,Lin ST,Mei Y,Qiang YY,Li CZ,Xu L,Peng XS,Hu H,Lang YH,Liu ZJ,Wang MD,Guo LL,Xie DH,Shu DT,Li HF,Luo FF,Niu XT,Huang BJ,Qian CN

Wed Jul 01 00:00:00 EDT 2020

Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.

International journal of molecular sciences

Wang Z,Liang M,Li H,Cai L,Yang L

Fri Dec 06 00:00:00 EST 2019

Downregulation of transgelin 2 promotes breast cancer metastasis by activating the reactive oxygen species/nuclear factor‑κB signaling pathway.

Molecular medicine reports

Yang L,Hong Q,Xu SG,Kuang XY,Di GH,Liu GY,Wu J,Shao ZM,Yu SJ

Fri Nov 01 00:00:00 EDT 2019

Paeonol-mediated apoptosis of hepatocellular carcinoma cells by NF-κB pathway.

Oncology letters

Li Q,Zhang Y,Sun J,Bo Q

Fri Feb 01 00:00:00 EST 2019

Bioinformatics

Protein Aliases: DKFZp686C01211; DNA-binding factor KBF1; EBP-1; MGC54151; NF KB; NF-kappabeta; NF-kB p50/p105; nuclear factor; nuclear factor kappa b; nuclear factor kappa-B DNA binding subunit; Nuclear factor NF-kappa-B p105 subunit; nuclear factor NF-kappa-B p50 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

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Gene Aliases: CVID12; EBP-1; KBF1; NF-kappa-B; NF-kappaB; NF-kB1; NFkappaB; NFKB-p105; NFKB-p50; NFKB1; p105; p50

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UniProt ID: (Human) P19838

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Entrez Gene ID: (Human) 4790

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Function(s)

regulatory region DNA binding transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding heat shock protein binding identical protein binding protein homodimerization activity actinin binding transcription regulatory region DNA binding protein heterodimerization activity Rel homology transcription factor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NFKB1 p105/p50 Polyclonal Antibody

NFKB1 p105/p50 Antibody (15506-1-AP) in WB

Product Details

15506-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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