Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA1-30410
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide (Mouse) (C terminal).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
IgG fraction
Storage buffer
PBS with 0.2% gelatin
Contains
0.1% sodium azide
Storage conditions
4° C, do not freeze
Shipping conditions
Wet ice
RRID
AB_1958956
Product Specific Information
PA1-30410 detects NFkB p52 from rat, human, mouse samples.
Target Information
The NFkB transcription factor was originally identified as a protein complex consisting of a DNA binding subunit and an associated protein. The subunit is functionally related to c-Rel p75 and Rel B p68. The p50 subunit was initially believed to be a functionally unique protein derived from the amino-terminus of a precursor designated p105. A cDNA has been isolated that encodes an alternative DNA binding subunit of NFkB. It is synthesized as a protein that is expressed in a variety of cell types and, like p105, undergoes cleavage to generate its NFkB subunit, in this case a protein designated p52 (previously referred to as p49). In contrast to p50 derived from p105, p52 acts in synergy with p65 to stimulate the HIV enhancer in transiently transfected Jurkat cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Lyt10; NF kappaB2; NF KB; NFKB, p52/p100 subunit; nuclear factor; nuclear factor kappa b; nuclear factor Kappa-B, subunit 2; Nuclear factor NF-kappa-B p100 subunit; nuclear factor NF-kappa-B p52 subunit; nuclear factor of Kappa light chain gene enhancer in B cells 2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100; Oncogene Lyt-10; OTTHUMP00000020371; transcription factor NFKB2
Gene Aliases: CVID10; H2TF1; lyt; LYT-10; LYT10; NF-kappaB2; NF-kB2; NFKB2; p100; p49; p49/p100; p50B; p52; RGD1307189
UniProt ID: (Human) Q00653, (Mouse) Q9WTK5
Entrez Gene ID: (Human) 4791, (Rat) 309452, (Mouse) 18034
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
follicular dendritic cell differentiation
germinal center formation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
inflammatory response
I-kappaB kinase/NF-kappaB signaling
aging
extracellular matrix organization
positive regulation of type I interferon production
response to lipopolysaccharide
response to cytokine
NIK/NF-kappaB signaling
innate immune response
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
spleen development
positive regulation of NF-kappaB transcription factor activity
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
signal transduction
lymph node development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support