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Product Details
MA5-15574
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2F1C2
Immunogen
Purified recombinant fragment of human NGFR expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_10987951
Product Specific Information
MA5-15574 targets NGFR in indirect ELISA, FACS, IF, and WB applications and shows reactivity with Human samples.
The MA5-15574 immunogen is purified recombinant fragment of human NGFR expressed in E. Coli.
MA5-15574 detects NGFR which has a predicted molecular weight of approximately 45kDa.
Target Information
Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD271; CD271 antigen; Gp80-LNGFR; low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; NGF receptor; p-75; p75 ICD; p75 ntr; TNFR superfamily, member 16; TNR16; Tumor necrosis factor receptor superfamily member 16
Gene Aliases: CD271; Gp80-LNGFR; NGFR; p75(NTR); p75NTR; TNFRSF16
UniProt ID: (Human) P08138
Entrez Gene ID: (Human) 4804
beta-amyloid binding
signal transducer activity
receptor activity
transmembrane signaling receptor activity
tumor necrosis factor-activated receptor activity
neurotrophin TRKA receptor binding
protein binding
Rab GTPase binding
ubiquitin protein ligase binding
nerve growth factor binding
preprotein binding
transmembrane signal receptor
intracellular protein transport
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
immune response
axon guidance
response to wounding
negative regulation of neuron projection development
sensory perception of pain
membrane protein intracellular domain proteolysis
positive regulation of myelination
positive regulation of synaptic transmission, cholinergic
response to lipopolysaccharide
circadian regulation of gene expression
tumor necrosis factor-mediated signaling pathway
cellular response to oxidative stress
positive regulation of Rho protein signal transduction
skeletal muscle cell differentiation
regulation of cell proliferation
glucose homeostasis
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
neurotrophin TRK receptor signaling pathway
negative regulation of axonogenesis
positive regulation of axonogenesis
positive regulation of protein kinase B signaling
negative regulation of mitochondrial depolarization
positive regulation of synaptic transmission, glutamatergic
apoptotic signaling pathway
positive regulation of neuron death
regulation of reactive oxygen species metabolic process
regulation of glucose import in response to insulin stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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