Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-72978
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide made to a C-terminal portion of the human CARD12 protein (between residues 950-1015) [UniProt Q9NPP4]
Conjugate
Form
Liquid
Concentration
1.09 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 30% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2718832
Target Information
NLRC4 encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CARD, LRR, and NACHT-containing protein; caspase recruitment domain family, member 12; Caspase recruitment domain-containing protein 12; CED-4-like protein Clan; Ice protease-activating factor; ICE-protease activating factor; Ipaf; NLR family CARD domain-containing protein 4; NLR family, CARD domain containing 4; NOD-like receptor C4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
Gene Aliases: 9530011P19Rik; AIFEC; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; FCAS4; IPAF; NLRC4; UNQ6189/PRO20215
UniProt ID: (Human) Q9NPP4, (Mouse) Q3UP24
Entrez Gene ID: (Human) 58484, (Mouse) 268973
activation of innate immune response
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
regulation of signal transduction
detection of bacterium
protein ubiquitination
defense response to bacterium
regulation of apoptotic process
positive regulation of apoptotic process
innate immune response
interleukin-1 beta secretion
positive regulation of NF-kappaB transcription factor activity
protein homooligomerization
pyroptosis
mitotic spindle assembly
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
immune system process
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of neuron apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support