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Product Details
MA5-16274
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
25N10E9
Immunogen
Recombinant mNLRP3 NOD domain protein (AA 216-385).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2537791
Target Information
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome, and neonatal-onset multisystem inflammatory disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cold autoinflammatory syndrome 1 homolog; Cold autoinflammatory syndrome 1 protein homolog; Cryopyrin; FLJ95925; mast cell maturation inducible protein 1; Mast cell maturation-associated-inducible protein 1; NACHT, LRR and PYD domains-containing protein 3; NACHT/LRR/pyrin domain-containing protein 3; PYRIN-containing APAF1-like protein 1
Gene Aliases: AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1; MWS; NALP3; Nlrp3; Pypaf1
UniProt ID: (Mouse) Q8R4B8
Entrez Gene ID: (Mouse) 216799
negative regulation of acute inflammatory response
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
negative regulation of NF-kappaB transcription factor activity
interleukin-1 beta production
interleukin-18 production
negative regulation of NF-kappaB import into nucleus
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
NLRP3 inflammasome complex assembly
interleukin-1 secretion
negative regulation of interleukin-1 beta secretion
positive regulation of interleukin-1 beta secretion
regulation of inflammatory response
negative regulation of inflammatory response
positive regulation of NF-kappaB transcription factor activity
defense response to virus
cellular response to lipopolysaccharide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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