Invitrogen

NMDAR1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

OPA1-04011

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

1:1,000-1:2,000
-

Immunohistochemistry (Frozen) (IHC (F))

1:1,000-1:2,000
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to amino acid residues specific to the NR1 subunit of rat GRIN1, N1 splice variant insert conjugated to KLH

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

whole serum

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_325646

Product Specific Information

This antibody is predicted to react with canine, chicken, human, non-human primate and Xenopus based on 100% sequence homology.

In Western blot, this antibody detects an ~100 kDa protein representing the NR1 N1 splice variant from rat brain homogenate. It shows no cross-reactivity with the NR1 C1, C2, or C2 splice variants.

Reconstitute with 50 µL of PBS. After reconstitution the antibody should be aliquotted and stored at -20ºC.

Target Information

NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: GluN1; Glun1r; Glutamate [NMDA] receptor subunit zeta-1; glutamate receptor; Glutamate receptor ionotropic, NMDA 1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; NMDA receptor 1; NMDZ1; NMZ1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; RP11-350O14.1

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Gene Aliases: GluN1; GluRdelta1; Glurz1; GluRzeta1; Grin1; M100174; NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174

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UniProt ID: (Rat) P35439, (Mouse) P35438

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Entrez Gene ID: (Rat) 24408, (Mouse) 14810

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Function(s)
ionotropic glutamate receptor activity NMDA glutamate receptor activity receptor binding extracellular-glutamate-gated ion channel activity cation channel activity calcium channel activity calcium ion binding protein binding calmodulin binding glycine binding glutamate binding enzyme binding voltage-gated cation channel activity glutamate receptor binding neurotransmitter binding protein heterodimerization activity protein dimerization activity receptor activity ion channel activity transmembrane signal receptor
Process(es)
conditioned taste aversion startle response suckling behavior response to amphetamine cation transport calcium ion transport cellular calcium ion homeostasis respiratory gaseous exchange learning or memory learning memory long-term memory associative learning adult locomotory behavior olfactory learning visual learning regulation of cell communication positive regulation of cell death response to organic cyclic compound response to amine propylene metabolic process sensory perception of pain pons maturation cerebral cortex development ion transmembrane transport regulation of ion transmembrane transport social behavior ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic regulation of membrane potential positive regulation of apoptotic process response to morphine regulation of neuron apoptotic process negative regulation of neuron apoptotic process regulation of respiratory gaseous exchange response to ethanol positive regulation of transcription from RNA polymerase II promoter regulation of synaptic plasticity regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity rhythmic process regulation of dendrite morphogenesis regulation of axonogenesis neuromuscular process protein tetramerization response to calcium ion regulation of synapse assembly calcium ion homeostasis excitatory postsynaptic potential prepulse inhibition male mating behavior response to fungicide calcium ion transmembrane transport cellular response to manganese ion positive regulation of excitatory postsynaptic potential transport ion transport chemical synaptic transmission cation transmembrane transport
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