Alomone Labs, LTD

NMDAR2B (GluN2B) (extracellular) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

AGC-003-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:600
-

Immunohistochemistry (Frozen) (IHC (F))

1:100
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)NTHEKRIYQSNMLNR, corresponding to amino acid residues323-337 of rat NMDA receptor 2B, Extracellular, N-terminus
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

Target Information

NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer’s Disease, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity. NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3. Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal dominant 6-related mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: GluN2B; GluRepsilon2; Glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor; Glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; glutamate receptor, ionotropic, NMDA2B; GRIN 2B; HGNC:4586; hNR 3; MGC142178; MGC142180; N-methyl D-aspartate receptor 2B; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NMDAR2B; NMDE2; NME2; NR2B; NR3

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Gene Aliases: AW490526; EIEE27; GluN2B; GRIN2B; hNR3; MRD6; NMDAR2B; NR2B

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UniProt ID: (Human) Q13224, (Mouse) Q01097, (Rat) Q00960

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Entrez Gene ID: (Human) 2904, (Mouse) 14812, (Rat) 24410

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Function(s)
NMDA glutamate receptor activity Ras guanyl-nucleotide exchange factor activity extracellular-glutamate-gated ion channel activity protein binding zinc ion binding glycine binding receptor activity ionotropic glutamate receptor activity receptor binding interleukin-1 receptor binding ion channel activity cation channel activity calcium channel activity beta-catenin binding drug binding D2 dopamine receptor binding ionotropic glutamate receptor binding neurotransmitter binding metal ion binding protein heterodimerization activity cell adhesion molecule binding transmembrane signal receptor
Process(es)
MAPK cascade transport glutamate receptor signaling pathway chemical synaptic transmission learning or memory ion transmembrane transport ionotropic glutamate receptor signaling pathway positive regulation of GTPase activity response to ethanol ephrin receptor signaling pathway action potential behavioral fear response in utero embryonic development startle response suckling behavior ion transport cation transport calcium ion transport sensory organ development learning memory associative learning embryo development regulation of protein kinase A signaling positive regulation of cell death positive regulation of glutamate secretion synaptic transmission, glutamatergic fear response receptor clustering regulation of MAPK cascade regulation of synaptic plasticity regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity behavioral response to pain rhythmic process positive regulation of synaptic transmission detection of mechanical stimulus involved in sensory perception of pain regulation of postsynaptic membrane potential excitatory postsynaptic potential long-term synaptic potentiation calcium ion transmembrane transport cation transmembrane transport response to amphetamine long-term memory response to mechanical stimulus response to toxic substance response to carbohydrate response to manganese ion cellular response to magnesium starvation response to organic cyclic compound response to amine hippocampus development cerebral cortex development response to magnesium ion multicellular organismal response to stress response to cytokine response to cocaine response to calcium ion response to methylmercury response to electrical stimulus response to other organism response to growth hormone response to fungicide cellular response to amino acid stimulus cellular response to manganese ion cellular response to dsRNA cellular response to growth factor stimulus cellular response to lipid cellular response to organic cyclic compound
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