Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Bovine
NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1. 2, Nav1. 3, Nav1. 5, Nav1. 7, Nav1. 8, Kv1. 3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E3 ubiquitin-protein ligase NOSIP; eNOS-interacting protein; Nitric oxide synthase-interacting protein; RING-type E3 ubiquitin transferase NOSIP
Gene Aliases: 2310061K06Rik; CGI-25; NOSIP
UniProt ID: (Human) Q9Y314, (Mouse) Q9D6T0
Entrez Gene ID: (Human) 51070, (Mouse) 66394
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