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Product Details
MA5-30709
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
130
Immunogen
Recombinant Human CCN3/NOV/IGFBP9 Protein (Met1-Met357)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2786400
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human CCN3/NOV/IGFBP9.
Target Information
NOV is a member of the CCN family of secreted, cysteine-rich regulatory proteins. The full-length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm's tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorigenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell-surface integrins, and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCN family member 3; Cellular communication network factor 3; IBP-9; IGF-binding protein 9; Insulin-like growth factor-binding protein 9; Nephro blastoma-overexpressed gene protein homolog; nephroblastoma-overexpressed gene protein homolog; NovH; Protein NOV homolog
Gene Aliases: CCN3; IBP-9; IGFBP-9; IGFBP9; NOV; NOVH
UniProt ID: (Human) P48745
Entrez Gene ID: (Human) 4856
angiogenesis
chondrocyte differentiation
cell-cell signaling
regulation of gene expression
fibroblast migration
negative regulation of myotube differentiation
smooth muscle cell migration
negative regulation of cell growth
cell adhesion mediated by integrin
endothelial cell chemotaxis
negative regulation of NF-kappaB import into nucleus
type B pancreatic cell proliferation
positive regulation of Notch signaling pathway
negative regulation of insulin secretion
smooth muscle cell proliferation
negative regulation of inflammatory response
cell chemotaxis
negative regulation of SMAD protein import into nucleus
negative regulation of cell death
hematopoietic stem cell homeostasis
endothelial cell-cell adhesion
negative regulation of monocyte chemotaxis
negative regulation of chondrocyte proliferation
negative regulation of sensory perception of pain
bone regeneration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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