Proteintech

NOX1 Polyclonal Antibody

FIGURE: 1 / 2

NOX1 Antibody (17772-1-AP) in WB

mouse colon tissue were subjected to SDS PAGE followed by western blot with (Product # 17772-1-AP) (NOX1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

Product Image Gallery

Product Details

17772-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-Dependent

View 37 publications 37 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

ELISA (ELISA)

Assay-Dependent

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NOX1 Fusion Protein Ag12187 (292-560 aa encoded by BC075014)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QQKVVITKV VMHPSKVLEL QMNKRGFSME VGQYIFVNCP SISLLEWHPF TLTSAPEEDF FSIHIRAAGD WTENLIRAFE QQYSPIPRIE VDGPFGTASE DVFQYEVAVL VGAGIGVTPF ASILKSIWYK FQCADHNLKT KKIYFYWICR ETGAFSWFNN LLTSLEQEME ELGKVGFLNY RLFLTGWDSN IVGHAALNFD KATDIVTGLK QKTSFGRPMW DNEFSTIATS HPKSVVGVFL CGPRTLAKSL RKCCHRYSSL DPRKVQFYFN (292-560 aa encoded by BC075014)

Target Information

Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Three splice variants of NOX1 have been identified, NOH-1L, NOH-1S and NOH-1Lv. NOH-1S is a voltage-gated proton channel that participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H (+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. NOX1 have the potential to be effective treatments for a range of ischemic diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

BRD9 Inhibition Attenuates Matrix Degradation and Pyroptosis in Nucleus Pulposus by Modulating the NOX1/ROS/NF-κB axis.

Inflammation

Deng Z,Zhang Y,Zhu Y,Zhu J,Li S,Huang Z,Qin T,Wu J,Zhang C,Chen W,Huang D,Ye W

Thu Jun 01 00:00:00 EDT 2023

BRD9 Inhibition Attenuates Matrix Degradation and Pyroptosis in Nucleus Pulposus by Modulating the NOX1/ROS/NF-κB axis.

Inflammation

Deng Z,Zhang Y,Zhu Y,Zhu J,Li S,Huang Z,Qin T,Wu J,Zhang C,Chen W,Huang D,Ye W

Thu Jun 01 00:00:00 EDT 2023

BRD9 Inhibition Attenuates Matrix Degradation and Pyroptosis in Nucleus Pulposus by Modulating the NOX1/ROS/NF-κB axis.

Inflammation

Deng Z,Zhang Y,Zhu Y,Zhu J,Li S,Huang Z,Qin T,Wu J,Zhang C,Chen W,Huang D,Ye W

Thu Jun 01 00:00:00 EDT 2023

BRD9 Inhibition Attenuates Matrix Degradation and Pyroptosis in Nucleus Pulposus by Modulating the NOX1/ROS/NF-κB axis.

Inflammation

Deng Z,Zhang Y,Zhu Y,Zhu J,Li S,Huang Z,Qin T,Wu J,Zhang C,Chen W,Huang D,Ye W

Thu Jun 01 00:00:00 EDT 2023

Deficiency of S100 calcium binding protein A9 attenuates vascular dysfunction in aged mice.

Redox biology

Zhao B,Yu J,Luo Y,Xie M,Qu C,Shi Q,Wang X,Zhao X,Kong L,Zhao Y,Guo Y

Sat Jul 01 00:00:00 EDT 2023

Rhein Inhibited Ferroptosis and EMT to Attenuate Diabetic Nephropathy by Regulating the Rac1/NOX1/β-Catenin Axis.

Frontiers in bioscience (Landmark edition)

Xiong D,Hu W,Han X,Cai Y

Thu May 25 00:00:00 EDT 2023

Frontiers in oncology

Wang J,Tao Z,Wang B,Xie Y,Wang Y,Li B,Cao J,Qiao X,Qin D,Zhong S,Hu X

Tue Jun 20 00:00:00 EDT 2023

Aqueous-soluble components of sporoderm-removed Ganoderma lucidum spore powder promote ferroptosis in oral squamous cell carcinoma.

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu

Wu X,Wu Q,Wang Y,Liu Y,Li Z,Liu Q,Huang Z,Li M,Zhang B,Zhan Q

Sun Apr 30 00:00:00 EDT 2023

HMGCL-induced β-hydroxybutyrate production attenuates hepatocellular carcinoma via DPP4-mediated ferroptosis susceptibility.

Hepatology international

Cui X,Yun X,Sun M,Li R,Lyu X,Lao Y,Qin X,Yu W

Sat Apr 01 00:00:00 EDT 2023

NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.

Cellular signalling

Qiu D,Song S,Chen N,Bian Y,Yuan C,Zhang W,Duan H,Shi Y

Tue Aug 01 00:00:00 EDT 2023

NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.

Cellular signalling

Qiu D,Song S,Chen N,Bian Y,Yuan C,Zhang W,Duan H,Shi Y

Tue Aug 01 00:00:00 EDT 2023

A Novel NOX Inhibitor Treatment Attenuates Parkinson's Disease-Related Pathology in Mouse Models.

International journal of molecular sciences

Ghosh AA,Verma DK,Cabrera G,Ofori K,Hernandez-Quijada K,Kim JK,Chung JH,Moore M,Moon SH,Seo JB,Kim YH

Tue Apr 12 00:00:00 EDT 2022

Expression of CD70 Modulates Nitric Oxide and Redox Status in Endothelial Cells.

Arteriosclerosis, thrombosis, and vascular biology

Pandey AK,Waldeck-Weiermair M,Wells QS,Xiao W,Yadav S,Eroglu E,Michel T,Loscalzo J

Thu Sep 01 00:00:00 EDT 2022

Graphene oxide leads to mitochondrial-dependent apoptosis by activating ROS-p53-mPTP pathway in intestinal cells.

The international journal of biochemistry & cell biology

Feng W,Wang J,Li B,Liu Y,Xu D,Cheng K,Zhuang J

Sun May 01 00:00:00 EDT 2022

Inhibition of Hypoxia-Inducible Factor Prolyl-Hydroxylase Modulates Platelet Function.

Thrombosis and haemostasis

Gu W,Qi J,Zhang S,Ding Y,Qiao J,Han Y

Sat Oct 01 00:00:00 EDT 2022

Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike RBD protein.

Critical care (London, England)

Zhang L,Zhang Y,Qin X,Jiang X,Zhang J,Mao L,Jiang Z,Jiang Y,Liu G,Qiu J,Chen C,Qiu F,Zou Z

Thu Jun 09 00:00:00 EDT 2022

Alisol B 23-Acetate Ameliorates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction by Inhibiting TLR4-NOX1/ROS Signaling Pathway in Caco-2 Cells.

Frontiers in pharmacology

Xia F,Li Y,Deng L,Ren R,Ge B,Liao Z,Xiang S,Zhou B

Sat Jul 16 00:00:00 EDT 2022

Accumulation of advanced oxidation protein products contributes to age-related impairment of gap junction intercellular communication in osteocytes of male mice.

Bone & joint research

Tu C,Lai S,Huang Z,Cai G,Zhao K,Gao J,Wu Z,Zhong Z

Fri Jul 01 00:00:00 EDT 2022

Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H₂O₂-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nrf2/HO-1 Signaling.

Frontiers in pharmacology

Yang T,Lin X,Li H,Zhou X,Fan F,Yang J,Luo Y,Liu X

Fri Jul 29 00:00:00 EDT 2022

Bromelain Ameliorates Atherosclerosis by Activating the TFEB-Mediated Autophagy and Antioxidant Pathways.

Antioxidants (Basel, Switzerland)

Chen CH,Hsia CC,Hu PA,Yeh CH,Chen CT,Peng CL,Wang CH,Lee TS

Thu Dec 29 00:00:00 EST 2022

β-amyloid protein induces mitophagy-dependent ferroptosis through the CD36/PINK/PARKIN pathway leading to blood-brain barrier destruction in Alzheimer's disease.

Cell & bioscience

Li J,Li M,Ge Y,Chen J,Ma J,Wang C,Sun M,Wang L,Yao S,Yao C

Thu May 26 00:00:00 EDT 2022

Suramin enhances chondrogenic properties by regulating the p67^phox/PI3K/AKT/SOX9 signalling pathway.

Bone & joint research

Liu ZM,Shen PC,Lu CC,Chou SH,Tien YC

Sat Oct 01 00:00:00 EDT 2022

Impact of Selective Renal Afferent Denervation on Oxidative Stress and Vascular Remodeling in Spontaneously Hypertensive Rats.

Antioxidants (Basel, Switzerland)

Wu LL,Zhang Y,Li XZ,Du XL,Gao Y,Wang JX,Wang XL,Chen Q,Li YH,Zhu GQ,Tan X

Fri May 20 00:00:00 EDT 2022

In utero hypoxia attenuated acetylcholine-mediated vasodilatation via CHRM3/p-NOS3 in fetal sheep MCA: role of ROS/ERK1/2.

Hypertension research : official journal of the Japanese Society of Hypertension

He Y,Su H,Li N,Zhang Y,Zhang P,Zhang Y,Ye Y,Zhang Y,Tang J,Xu Z

Fri Jul 01 00:00:00 EDT 2022

Optical Visualization of Red-GQDs' Organelles Distribution and Localization in Living Cells.

Frontiers in pharmacology

Hu H,Li P,Qiu J,Zhao M,Kuang M,Zhang Z,Wang D

Tue Aug 02 00:00:00 EDT 2022

New Deferric Amine Compounds Efficiently Chelate Excess Iron to Treat Iron Overload Disorders and to Prevent Ferroptosis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Feng W,Xiao Y,Zhao C,Zhang Z,Liu W,Ma J,Ganz T,Zhang J,Liu S

Sat Oct 01 00:00:00 EDT 2022

Hydrogen sulfide attenuates ferroptosis and stimulates autophagy by blocking mTOR signaling in sepsis-induced acute lung injury.

Molecular immunology

Li J,Li M,Li L,Ma J,Yao C,Yao S

Sat Jan 01 00:00:00 EST 2022

NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy.

Journal of translational medicine

Qiu D,Song S,Wang Y,Bian Y,Wu M,Wu H,Shi Y,Duan H

Fri Jan 28 00:00:00 EST 2022

NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy.

Journal of translational medicine

Qiu D,Song S,Wang Y,Bian Y,Wu M,Wu H,Shi Y,Duan H

Fri Jan 28 00:00:00 EST 2022

Hypoxia-induced LINC00674 facilitates hepatocellular carcinoma progression by activating the NOX1/mTOR signaling pathway.

Journal of Cancer

Zhu N,Chen X,Zhao J,Fang L,Yao Y,Zhou F,Tao L,Xu Q

Tue Sep 20 00:00:00 EDT 2022

Hypoxia-induced LINC00674 facilitates hepatocellular carcinoma progression by activating the NOX1/mTOR signaling pathway.

Journal of Cancer

Zhu N,Chen X,Zhao J,Fang L,Yao Y,Zhou F,Tao L,Xu Q

Tue Sep 20 00:00:00 EDT 2022

H. sinensis mycelium inhibits epithelial-mesenchymal transition by inactivating the midkine pathway in pulmonary fibrosis.

Frontiers of medicine

Lu L,Zhu H,Wang H,Liang H,Hou Y,Dou H

Thu Apr 01 00:00:00 EDT 2021

RND3 attenuates oxidative stress and vascular remodeling in spontaneously hypertensive rat via inhibiting ROCK1 signaling.

Redox biology

Wu N,Zheng F,Li N,Han Y,Xiong XQ,Wang JJ,Chen Q,Li YH,Zhu GQ,Zhou YB

Mon Dec 06 00:00:00 EST 2021

Distinction between 2'- and 3'-Phosphate Isomers of a Fluorescent NADPH Analogue Led to Strong Inhibition of Cancer Cells Migration.

Antioxidants (Basel, Switzerland)

Manuel R,Lima MS,Dilly S,Daunay S,Abbe P,Pramil E,Solier S,Guillaumond F,Tubiana SS,Escargueil A,Pêgas Henriques JA,Ferrand N,Erdelmeier I,Boucher JL,Bertho G,Agranat I,Rocchi S,Sabbah M,Slama Schwok A

Tue May 04 00:00:00 EDT 2021

An Antioxidant Sesquiterpene Inhibits Osteoclastogenesis Via Blocking IPMK/TRAF6 and Counteracts OVX-Induced Osteoporosis in Mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wang S,Ma Q,Xie Z,Shen Y,Zheng B,Jiang C,Yuan P,An Q,Fan S,Jie Z

Wed Sep 01 00:00:00 EDT 2021

DDX19A Promotes Metastasis of Cervical Squamous Cell Carcinoma by Inducing NOX1-Mediated ROS Production.

Frontiers in oncology

Jiang Y,Wang B,Li Y,Shen J,Wei Y,Li H,Chen S,Yang H,Zeng F,Liu C,Wang F,He H,Chen Y,Liu J

Mon Jun 27 00:00:00 EDT 2022

Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector.

Oxidative medicine and cellular longevity

Li X,Wang X,Miao L,Guo Y,Yuan R,Ren J,Huang Y,Tian H

Fri Jan 28 00:00:00 EST 2022

Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway.

Antioxidants (Basel, Switzerland)

Dong X,Wu D,Zhang Y,Jia L,Pan X,Sun J,Pan LL

Fri Jun 05 00:00:00 EDT 2020

Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.

PLoS biology

Ma D,Zheng B,Liu HL,Zhao YB,Liu X,Zhang XH,Li Q,Shi WB,Suzuki T,Wen JK

Sat Aug 01 00:00:00 EDT 2020

Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF-β1-NOX4 Pathway.

Journal of molecular neuroscience : MN

Tan X,Li T,Zhu S,Zhong W,Li F,Wang Y

Sun Nov 01 00:00:00 EDT 2020

Effect of phenylacetamide isolated from lepidium apetalum on myocardial injury in spontaneously hypertensive rats and its possible mechanism.

Pharmaceutical biology

Zhang Q,Yuan P,Li M,Fu Y,Hou Y,Sun Y,Gao L,Wei Y,Feng W,Zheng X

Tue Dec 01 00:00:00 EST 2020

p47phox deficiency impairs platelet function and protects mice against arterial and venous thrombosis.

Redox biology

Wang X,Zhang S,Ding Y,Tong H,Xu X,Wei G,Chen Y,Ju W,Fu C,Qi K,Li Z,Zeng L,Xu K,Qiao J

Wed Jul 01 00:00:00 EDT 2020

Megakaryocytic Leukemia 1 Bridges Epigenetic Activation of NADPH Oxidase in Macrophages to Cardiac Ischemia-Reperfusion Injury.

Circulation

Yu L,Yang G,Zhang X,Wang P,Weng X,Yang Y,Li Z,Fang M,Xu Y,Sun A,Ge J

Tue Dec 11 00:00:00 EST 2018

Megakaryocytic Leukemia 1 Bridges Epigenetic Activation of NADPH Oxidase in Macrophages to Cardiac Ischemia-Reperfusion Injury.

Circulation

Yu L,Yang G,Zhang X,Wang P,Weng X,Yang Y,Li Z,Fang M,Xu Y,Sun A,Ge J

Tue Dec 11 00:00:00 EST 2018

MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.

Antioxidants & redox signaling

Ren T,Wang J,Zhang H,Yuan P,Zhu J,Wu Y,Huang Q,Guo X,Zhang J,Ji L,Li J,Zhang H,Yang H,Xing J

Fri Apr 20 00:00:00 EDT 2018

MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.

Antioxidants & redox signaling

Ren T,Wang J,Zhang H,Yuan P,Zhu J,Wu Y,Huang Q,Guo X,Zhang J,Ji L,Li J,Zhang H,Yang H,Xing J

Fri Apr 20 00:00:00 EDT 2018

Bioinformatics

Protein Aliases: GP91 phox homolog; mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating); Mitogenic oxidase 1; MOX-1; MOX1; NADH/NADPH mitogenic oxidase subunit P65-MOX; NADPH oxidase 1; NADPH oxidase 1 alpha; NADPH oxidase homolog-1; NOH-1; NOX-1

View more View less

Gene Aliases: GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1; NOX1a; NOX1alpha

View more View less

UniProt ID: (Human) Q9Y5S8, (Rat) Q9WV87, (Mouse) Q8CIZ9

View more View less

Entrez Gene ID: (Human) 27035, (Rat) 114243, (Mouse) 237038

View more View less

Function(s)

protein binding superoxide-generating NADPH oxidase activity voltage-gated proton channel activity metal ion binding Rac GTPase binding NADP binding N-ethylmaleimide reductase activity oxidoreductase activity reduced coenzyme F420 dehydrogenase activity sulfur oxygenase reductase activity malolactic enzyme activity NADPH:sulfur oxidoreductase activity epoxyqueuosine reductase activity oxidase

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

NOX1 Polyclonal Antibody

NOX1 Antibody (17772-1-AP) in WB

Product Details

17772-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

ELISA (ELISA)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!