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Product Details
PA5-120150
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human NOX1 (NP_008983.2).
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2913722
Product Specific Information
Positive test controls include: HT-29, 22Rv1. The target is usually found in the following locations: Cell projection, Multi-pass membrane protein, invadopodium membrane.
Immunogen sequence: YFEVFWYTHH LFIFYILGLG IHGIGGIVRG QTEESMNESH PRKCAESFEM WDDRDSHCRR PKFEGHPPES WKWILAPVIL YICERILRFY RSQQKVVITK V
Target Information
Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Three splice variants of NOX1 have been identified, NOH-1L, NOH-1S and NOH-1Lv. NOH-1S is a voltage-gated proton channel that participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H (+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. NOX1 have the potential to be effective treatments for a range of ischemic diseases.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating); Mitogenic oxidase 1; MOX-1; NADH/NADPH mitogenic oxidase subunit P65-MOX; NADPH oxidase 1; NADPH oxidase homolog-1; NOH-1; NOX-1
Gene Aliases: GP91-2; MOX1; NOH-1; NOH1; NOX1
UniProt ID: (Human) Q9Y5S8
Entrez Gene ID: (Human) 27035
angiogenesis
regulation of systemic arterial blood pressure by renin-angiotensin
NADP metabolic process
superoxide metabolic process
inflammatory response
signal transduction
regulation of blood pressure
positive regulation of cell proliferation
positive regulation of vascular endothelial growth factor production
proton transport
cell migration
extracellular matrix organization
regulation of ion transmembrane transport
superoxide anion generation
hydrogen peroxide metabolic process
positive regulation of integrin biosynthetic process
respiratory burst
positive regulation of JNK cascade
positive regulation of smooth muscle cell proliferation
intracellular pH elevation
oxidation-reduction process
cellular response to hyperoxia
oxygen metabolic process
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
cellular stress response to acidic pH
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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