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Product Details
PA5-142645
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-DKATDIVTGLKQK.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2933291
Product Specific Information
Additional Information: This antibody is expected to recognize both reported isoforms (NP_008983.2; NP_39249.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Three splice variants of NOX1 have been identified, NOH-1L, NOH-1S and NOH-1Lv. NOH-1S is a voltage-gated proton channel that participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H (+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. NOX1 have the potential to be effective treatments for a range of ischemic diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating); Mitogenic oxidase 1; MOX-1; NADH/NADPH mitogenic oxidase subunit P65-MOX; NADPH oxidase 1; NADPH oxidase homolog-1; NOH-1; NOX-1
Gene Aliases: GP91-2; MOX1; NOH-1; NOH1; NOX1
UniProt ID: (Human) Q9Y5S8
Entrez Gene ID: (Human) 27035
angiogenesis
regulation of systemic arterial blood pressure by renin-angiotensin
NADP metabolic process
superoxide metabolic process
inflammatory response
signal transduction
regulation of blood pressure
positive regulation of cell proliferation
positive regulation of vascular endothelial growth factor production
proton transport
cell migration
extracellular matrix organization
regulation of ion transmembrane transport
superoxide anion generation
hydrogen peroxide metabolic process
positive regulation of integrin biosynthetic process
respiratory burst
positive regulation of JNK cascade
positive regulation of smooth muscle cell proliferation
intracellular pH elevation
oxidation-reduction process
cellular response to hyperoxia
oxygen metabolic process
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
cellular stress response to acidic pH
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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