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Product Details
67681-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4E5F1
Immunogen
NOX4 Fusion Protein Ag6176
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; KOX-1; KOX1; NADPH oxidase 4; NOX 4; NOX-4; Renal NAD(P)H-oxidase
Gene Aliases: KOX; KOX-1; NOX4; RENOX
UniProt ID: (Human) Q9NPH5, (Rat) Q924V1
Entrez Gene ID: (Human) 50507, (Rat) 85431
nucleotide binding
protein binding
electron carrier activity
NAD(P)H oxidase activity
superoxide-generating NADPH oxidase activity
oxygen sensor activity
heme binding
flavin adenine dinucleotide binding
modified amino acid binding
oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
oxidase
response to reactive oxygen species
cell morphogenesis
response to hypoxia
superoxide metabolic process
inflammatory response
cell aging
negative regulation of cell proliferation
gene expression
positive regulation of smooth muscle cell migration
superoxide anion generation
positive regulation of apoptotic process
positive regulation of MAP kinase activity
bone resorption
homocysteine metabolic process
positive regulation of stress fiber assembly
positive regulation of protein kinase B signaling
cardiac muscle cell differentiation
oxidation-reduction process
positive regulation of ERK1 and ERK2 cascade
cellular response to cAMP
cellular response to glucose stimulus
cellular response to gamma radiation
cellular response to transforming growth factor beta stimulus
reactive oxygen species metabolic process
positive regulation of reactive oxygen species metabolic process
positive regulation of DNA biosynthetic process
aging
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